Year 2019 / Volume 111 / Number 1
Original
Vitamin D deficiency in outpatients with inflammatory bowel disease: prevalence and association with clinical-biological activity

46-54

DOI: 10.17235/reed.2018.5714/2018

Raúl Vicente Olmedo Martín, Inmaculada González Molero, Gabriel Olveira Fuster, Víctor Amo Trillo, Miguel Jiménez Pérez,

Abstract
Introduction: there are few data on the prevalence of vitamin D deficiency in patients with inflammatory bowel disease (IBD) in Spain. A deficiency could be associated with a worse course of the disease. Aim: to determine the prevalence of 25-hydroxyvitamin D (25OHD) deficiency in a cohort of outpatients with IBD and assess its association with clinical and biological activity, quality of life and psychological symptoms. Methods: a cross-sectional, single-center observational study was performed. The study variables were obtained via clinical interviews, medical chart review and validated questionnaires (Hospital Anxiety and Depression Scale and Short Quality of Life in Inflammatory Bowel Disease Questionnaire). 25OHD was measured in the same laboratory by an electro-chemiluminescence immunoassay. Results: the study included 224 patients. The prevalence of vitamin D deficiency in Crohn’s disease and ulcerative colitis was 33.3% and 20.3%, respectively. In Crohn’s disease, vitamin D deficiency was associated with a higher clinical activity (p < 0.001) and a higher concentration of fecal calprotectin (p = 0.01). In ulcerative colitis, it was associated with clinical activity (p < 0.001), the use of steroids during the last six months (p = 0.001) and hospital admission during the previous year (p = 0.003). A sub-analysis of 149 patients failed to detect an association between vitamin D and quality of life or the scores of the Hospital Anxiety and Depression Scale. Conclusions: vitamin D deficiency is common in patients with inflammatory bowel disease. An association was found between vitamin D concentration and clinical activity indexes, as well as fecal calprotectin levels in Crohn’s disease.
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Olmedo Martín R, González Molero I, Olveira Fuster G, Amo Trillo V, Jiménez Pérez M. Vitamin D deficiency in outpatients with inflammatory bowel disease: prevalence and association with clinical-biological activity. 5714/2018


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Publication history

Received: 09/05/2018

Accepted: 10/07/2018

Online First: 04/10/2018

Published: 17/01/2019

Article revision time: 57 days

Article Online First time: 148 days

Article editing time: 253 days


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