Year 2021 / Volume 113 / Number 12
Letter
Inflammatory bowel disease new-onset during secukinumab therapy: real-world data from a tertiary center

858-859

DOI: 10.17235/reed.2021.8397/2021

Asuncion Ojeda Gómez, Lucía Madero Velázquez, Lidia Buendía Sanchez, Irene Pascual Sánchez, Estefanía Pérez Rabasco, Ana García Monsalve, José Antonio González Ferrández, Mariana Fe García Sepulcre,

Abstract
Secukinumab is a monoclonal antibody that inhibits interleukin-17A. It is currently prescribed for the treatment of psoriasis, psoriatic arthritis and ankylosing spondylitis, which are immune-mediated diseases that show significant co-heritability with inflammatory bowel disease (IBD). Although this treatment appears to be well tolerated by patients, several cases of new-onset IBD after secukinumab have been reported during the last years.
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References
1. Fauny M, Moulin D, D'Amico F et al. Paradoxical gastrointestinal effects of interleukin-17 blockers. Ann Rheum Dis. 2020 Sep;79(9):1132-1138. doi: 10.1136/annrheumdis-2020-217927.
2. Schreiber S, Colombel JF, Feagan BG, et al. Incidence rates of inflammatory bowel disease in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis treated with secukinumab: a retrospective analysis of pooled data from 21 clinical trials. Ann Rheum Dis. 2019 Apr;78(4):473-479. doi: 10.1136/annrheumdis-2018-214273.
3. Rodríguez R, Vázquez JM, Pallarés H. Debut de colitis ulcerosa en contexto de tratamiento con secukinumab: ¿los anti-IL-17A pueden ser un factor desencadenante para la aparición de la enfermedad inflamatoria intestinal? Rev Esp Enferm Dig 2019:111(9):720-721 DOI: 10.17235/reed.2019.5841/2018
4. Fries W et al. Inflammatory Bowel Disease Onset During Secukinumab Treatment: Real Concern or Just an Expression of Dysregulated Immune Response? Clin Drug Investig. 2019 Aug;39(8):799-803. doi: 10.1007/s40261-019-00803-7
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Citation tools
Ojeda Gómez A, Madero Velázquez L, Buendía Sanchez L, Pascual Sánchez I, Pérez Rabasco E, García Monsalve A, et all. Inflammatory bowel disease new-onset during secukinumab therapy: real-world data from a tertiary center. 8397/2021


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Publication history

Received: 14/10/2021

Accepted: 18/10/2021

Online First: 26/10/2021

Published: 09/12/2021

Article Online First time: 12 days

Article editing time: 56 days


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