Year 2010 / Volume 102 / Number 11
Original
Irritable bowel syndrome immune hypothesis. Part one: the role of lymphocytes and mast cells

pp. 637-647

M. Ortiz Lucas, P. Saz Peiró y J. J. Sebastián Domingo

Abstract
Objective: To review the available evidence on the role of Tlymphocytes and mast cells in the etiopathogenesis of Irritable Bowel Syndrome.

Methods: Bibliographic retrieval on PubMed including the terms “Irritable Bowel Syndrome, “Immune System”, “T-Lymphocytes”
and “Mast Cells”.

Results: Twenty-five case-control studies and one randomized controlled trial were retrieved. Noteworthy in the blood is the increase
in activated T cells destined to migrate to the bowel in these patients. A high frequency of T-lymphocytes is described in the intestinal mucosa, although the study findings are, at times,
contradictory. An evident increase in mast cells (and in their activity) between the terminal ileum and descending colon is also observed.

Conclusions: The heterogeneity of diagnostic criteria and experimentation methods could account for some of the differences
in the results found in the selected research. There are indications that give reason to believe these patients have “low-grade intestinal
inflammation”, and the increase in T-lymphocytes and mast cells has been associated with disorders found in IBS such as the communication between the intestine and the nervous system, the
increase in intestinal permeability and changes in the microbiota.
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M. Ortiz Lucas, P. Saz Peiró y J. J. Sebastián Domingo. Irritable bowel syndrome immune hypothesis. Part one: the role of lymphocytes and mast cells. 637-647


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