Year 2023 / Volume 115 / Number 11
Letter
Immune checkpoint inhibitor-mediated colitis in a patient with epidermoid metastatic lung cancer: new and emerging toxicities

663

DOI: 10.17235/reed.2023.9813/2023

Marta Álvarez-García, Lola Otegui, Sergio Farrais Villalba, Juan Carlos Porres Cubero,

Abstract
In recent years, the development of immunotherapy has been stablished with monoclonals antibodies against control immune molecules in T lymphocytes, tumor cells and other cells, which block lymphocyte activation and suppress immune response. These molecules are Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) and Programmed Death-ligand 1 (PD-1). Despite clinical benefits, these therapies are not exempt from side effects known as immune-related adverse events (irAEs). We report the case of a 68-year-old female with stage IIIB epidermoid lung cancer diagnosed in 2017.
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References
1. Céspedes Martínez E, Robles Alonso V, Herrera-De Guise C, Mayorga L, Casellas F, Roca-Herrera M, Borruel N. Severe and refractory gastrointestinal toxicity due to immune checkpoint inhibitors: clinical experience in a tertiary referral hospital. Rev Esp Enferm Dig. 2023 May 12. doi: 10.17235/reed.2023.9436/2022. Epub ahead of print. PMID: 37170542.
2. Hashash JG, Francis FF, Farraye FA. Diagnosis and Management of Immune Checkpoint Inhibitor Colitis. Gastroenterol Hepatol. agosto de 2021;17(8):358-66.
3. Dougan M, Wang Y, Rubio-Tapia A, Lim JK. AGA Clinical Practice Update on Diagnosis and Management of Immune Checkpoint Inhibitor Colitis and Hepatitis: Expert Review. Gastroenterology. marzo de 2021;160(4):1384-93.
4. Fernández-Gordón Sánchez FM, Gómez-Domínguez E, Paredes Ruiz D, Rodríguez Gil Y, Martín Algíbez A, Fernández Vázquez I, Martínez Montiel P. Ustekinumab for corticodependent immune-mediated colitis by pembrolizumab, an alternative for patients with concomitant liver injury. Rev Esp Enferm Dig. 2022;114:356-357.
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Álvarez-García M, Otegui L, Farrais Villalba S, Porres Cubero J. Immune checkpoint inhibitor-mediated colitis in a patient with epidermoid metastatic lung cancer: new and emerging toxicities. 9813/2023


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Publication history

Received: 02/07/2023

Accepted: 13/07/2023

Online First: 04/08/2023

Published: 13/11/2023

Article Online First time: 33 days

Article editing time: 134 days


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