Year 2019 / Volume 111 / Number 9
Letter
The onset of ulcerative colitis during treatment with secukinumab: can anti-IL-17A be a trigger for inflammatory bowel disease?

720-721

DOI: 10.17235/reed.2019.5841/2018

Rafael Rodríguez Moncada, Juan María Vázquez Morón, Héctor Pallarés Manrique,

Abstract
In recent months, cases of IBD have been reported in the context of treatment with secukinumab, a monoclonal antibody that blocks IL-17A and which is used in the treatment of certain rheumatic disorders. We present a case of a patient with psoriatic arthritis, with a first-degree relative who had suffered ulcerative colitis, who presented with onset ulcerative colitis in the weeks following treatment initiation with this drug.
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References
Fobelo Lozano MJ, Serrano Giménez R, Castro Fernández M. Emergence of Inflammatory Bowel Disease During Treatment with Secukinumab. J Crohns Colitis. 2018 May 9. doi: 10.1093/ecco-jcc/jjy063.
Abraham C, Dulai PS, Vermeire S et al. Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. Gastroenterology 2017; 152(2): 374–88. doi: 10.1053/j.gastro.2016.10.018.
Ungaro R, Mehandru S, Allen PB et al. Ulcerative colitis. Lancet 2017; 389: 1756–70. doi: 10.1016/S0140-6736(16)32126-2.
Wang J, Bhatia A, Krugliak Cleveland N et al. Rapid Onset of Inflammatory Bowel Disease after Receiving Secukinumab Infusion. ACG Case Rep J 2018. doi: 10.14309/crj.2018.56.
Ehrlich D, Jamaluddin N, Pisegna J et al. A Challenging Case of Severe Ulcerative Colitis following the Initiation of Secukinumab for Ankylosing Spondylitis. Case Rep Gastrointest Med 2018. doi: 10.1155/2018/9679287.
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Rodríguez Moncada R, Vázquez Morón J, Pallarés Manrique H. The onset of ulcerative colitis during treatment with secukinumab: can anti-IL-17A be a trigger for inflammatory bowel disease? . 5841/2018


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Publication history

Received: 24/07/2018

Accepted: 10/10/2018

Online First: 23/07/2019

Published: 05/09/2019

Article revision time: 75 days

Article Online First time: 364 days

Article editing time: 408 days


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