Year 2025 / Volume 117 / Number 10
Letter
Utility of the derived neutrophil-to-lymphocyte ratio as a predictor of complicated appendicitis in pediatrics

597-598

DOI: 10.17235/reed.2024.10642/2024

Julio César Moreno-Alfonso, Sharom Barbosa-Velásquez, Ada Molina Caballero, Alberto Pérez Martínez, María Concepción Yárnoz Irazábal,

Abstract
Between 16-40% of patients present with complicated appendicitis at the time of diagnosis, making early suspicion of appendicular perforation key for initiating timely treatment and reducing morbidity and mortality. This study evaluates the accuracy of the derived neutrophil-to-lymphocyte ratio (dNLR) as a predictor of complicated appendicitis. A diagnostic study was conducted, including patients aged 0-15 years who underwent appendectomy at a pediatric hospital between 2021-2022 (Reg. 2023/390894).
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References
1. van den Bogaard VA, Euser SM, van der Ploeg T, et al. Diagnosing perforated appendicitis in pediatric patients: a new model. J Pediatr Surg 2016;51(3):444-8. DOI: 10.1016/j.jpedsurg.2015.10.054
2. Moreno-Alfonso JC, Barbosa Velásquez S, Mesa Helguera S, Molina Caballero A, Yárnoz Irazábal MC, Pérez Martínez A. Derived neutrophil-to-lymphocyte ratio (dNLR) as a diagnostic biomarker of pediatric acute appendicitis. Rev Esp Enferm Dig 2024. DOI: 10.17235/reed.2024.10497/2024. In Press
3. Ha SC, Tsai YH, Koh CC, Hong SG, Chen Y, Yao CL. Blood biomarkers to distinguish complicated and uncomplicated appendicitis in pediatric patients. J Formos Med Assoc 2024:S0929-6646(24)00056-1. DOI: 10.1016/j.jfma.2024.01.023
4. Lin WY, Lee EP, Chen CY, Guo BC, Lin MJ, Wu HP. The Role of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Predicting Complicated Appendicitis in Children. Diagnostics (Basel) 2024;14(12):1256. DOI: 10.3390/diagnostics14121256
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Moreno-Alfonso J, Barbosa-Velásquez S, Molina Caballero A, Pérez Martínez A, Yárnoz Irazábal M. Utility of the derived neutrophil-to-lymphocyte ratio as a predictor of complicated appendicitis in pediatrics. 10642/2024


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Publication history

Received: 09/07/2024

Accepted: 11/07/2024

Online First: 01/08/2024

Published: 10/10/2025

Article Online First time: 23 days

Article editing time: 458 days


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