Year 2016 / Volume 108 / Number 7
Original
Tendencies and outcomes in endoscopic biliary sphincterotomies among people with or without type 2 diabetes mellitus in Spain, 2003-2013

386-393

DOI: 10.17235/reed.2016.4276/2016

Jose de Miguel-Yanes, Manuel Méndez-Bailón, Rodrigo Jiménez-García, Cecilia González-Asanza, Valentín Hernández-Barrera, Nuria Muñoz-Rivas, Ana López-de-Andrés,

Abstract
We aimed to compare incidence and outcomes for endoscopic biliary sphincterotomies in people with or without type 2 diabetes mellitus (T2DM) in Spain (2003-2013). We collected all cases of endoscopic biliary sphincterotomies using national hospital discharge data and evaluated annual incident rates stratified by T2DM status. We analyzed trends over time for in-hospital mortality (IHM) as the primary outcome and a composite of IHM or procedure-related complications (key secondary outcome). In multivariate analyses, we tested T2DM as an independent factor of IHM and IHM or complications. We identified 126,885 endoscopic biliary sphincterotomies (23,002 [18.1%] in T2DM people). Crude incidence rates of endoscopic biliary sphincterotomies were > 3-fold higher in people with vs without T2DM (85.5/105 vs 26.9/105 population, respectively). Annual incidence rates of endoscopic biliary sphincterotomies showed 11-year relative increments of 77.5% (from 60.0 to 106.5/105) in T2DM, and 53.7% (from 21.6 to 33.2/105) in non-T2DM people (p < 0.001). We found no significant changes in mortality trends over time for the populations with or without T2DM (p = 0.15 and p = 0.21, respectively). Rates of procedural pancreatitis decreased in people without T2DM (p < 0.001). In the multivariate analysis, older age, higher comorbidity and endoscopic biliary sphincterotomy during urgent admission were associated with a higher IHM. T2DM was associated with a lower IHM after an endoscopic biliary sphincterotomy (OR = 0.82 [0.74-0.92]). Time trend multivariate analyses 2003-2013 showed significant reductions in IHM over time only in people with T2DM (OR = 0.97 [0.94-1.00]). Further studies are needed to confirm a lower IHM for endoscopic biliary sphincterotomies in people with T2DM.
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References
1. Ikeda S, Tanaka M, Matsumoto S, et al. Endoscopic sphincterotomy: Long-term results in 408 patients with complete follow-up. Endoscopy 1988; 20:13-7.
2. Fan ST, Lai EC, Mok FP, et al. Early treatment of acute biliary pancreatitis by endoscopic papillotomy. N Engl J Med 1993; 328:228-32.
3. Freeman ML, Nelson DB, Sherman S, et al. Complications of endoscopic biliary sphincterotomy. N Engl J Med 1996; 335:909-18.
4. Fölsch UR, Nitsche R, Lüdtke R, et al. Early ERCP and papillotomy compared with conservative treatment for acute biliary pancreatitis. The German Study Group on Acute Biliary Pancreatitis. N Engl J Med 1997; 336:237-42.
5. Hammarstrom LE, Holmin T, Stridbeck H. Endoscopic treatment of bile duct calculi in patients with gallbladder in situ: long-term outcome and factors. Scand J Gastroenterol 1996; 31:294-301.
6. Bergman JJ, Rauws EA, Fockens P, et al. Randomised trial of endoscopic balloon dilation versus endoscopic sphincterotomy for removal of bileduct stones. Lancet 1997; 349:1124-29.
7. Kogure H, Tsujino T, Isayama H, et al. Short- and long-term outcomes of endoscopic papillary large balloon dilation with or without sphincterotomy for removal of large bile duct stones. Scand J Gastroenterol 2014; 49:121-28.
8. Doi S, Yasuda I, Mukai T, et al. Comparison of long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation: a propensity score-based cohort analysis. J Gastroenterol 2013; 48:1090-6.
9. Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27:1047-53.
10. Soriguer F, Goday A, Bosch-Comas A, et al. Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study. Diabetologia 2012; 55:88-93.
11. Instituto Nacional de Gestión Sanitaria, Ministerio de Sanidad y Consumo: Conjunto Mínimo Básico de Datos, Hospitales del INSALUD. Available at http://www.ingesa.msc.es/estadEstudios/documPublica/CMBD-2001.htm (accessed December 09, 2014).
12. Centers for Disease Control and Prevention. http://www.cdc.gov/nchs/icd/icd9cm.htm (accessed December 04, 2014).
13. Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40:373-83.
14. Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992; 45:613-19.
15. Instituto Nacional de Estadística (INE): Population estimates. Available at http://www.ine.es (accessed 01 December 2014).Ministerio de Sanidad, Servicios Sociales e Igualdad.
16. http://www.msssi.gob.es/estadEstudios/estadisticas/encuestaNacional/ (accessed 28 November 2014).
17. Pagliarulo M, Fornari F, Fraquelli M. Gallstone disease and related risk factors in a large cohort of diabetic patients. Dig Liver Dis 2004; 36:130-34.
18. Sandzén B, Haapamäki MM, Nilsson E, et al. Treatment of common bile duct stones in Sweden 1989-2006: an observational nationwide study of a paradigm shift. World J Surg 2012; 36:2146-53.
19. Disario JA, Freeman ML, Bjorkman DJ, et al. Endoscopic balloon dilation compared with sphincterotomy for extraction of bile duct stones. Gastroenterology 2004; 127:1291-99.
20. Aiura K, Kitagawa Y. Current status of endoscopic papillary balloon dilation for the treatment of bile duct stones. J Hepatobiliary Pancreat Sci 2011; 18:339-45.
21. Binmoeller KF, Harris AG, Dumas R, et al. Does the somatostatin analogue octreotide protect against ERCP induced pancreatitis? Gut 1992; 33:1129-33.
22. Dasari BV, Tan CJ, Gurusamy KS, Martin DJ, Kirk G, McKie L, et al. Surgical versus endoscopic treatment of bile duct stones. Cochrane Database Syst Rev 2013; 12:CD003327.
23. Yang Y, Salam ZH, Ong BC, et al. Respiratory dysfunction in patients with sepsis: protective effect of diabetes mellitus. Am J Crit Care 2011; 20:e41-47.
24. Koh GCKW, Peacock SJ, van der Poll T, et al. The impact of diabetes on the pathogenesis of sepsis. Eur J Clin Microbiol Infect Dis 2012; 31:379-88.
25. Gruberg L, Weissman NJ, Waksman R, F et al. The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox? J Am Coll Cardiol 2002; 39:578-84.
26. Leong A, Dasgupta K, Bernatsky S, et al. Systematic Review and Meta-Analysis of Validation Studies on a Diabetes Case Definition from Health Administrative Records. PLoS One 2013; 8: e75256.
27. Ribera A, Marsal JR, Ferreira-González I, et al. Predicting in-hospital mortality with coronary bypass surgery using hospital discharge data: comparison with a prospective observational study. Rev Esp Cardiol 2008; 61:843-52.
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de Miguel-Yanes J, Méndez-Bailón M, Jiménez-García R, González-Asanza C, Hernández-Barrera V, Muñoz-Rivas N, et all. Tendencies and outcomes in endoscopic biliary sphincterotomies among people with or without type 2 diabetes mellitus in Spain, 2003-2013. 4276/2016


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Publication history

Received: 18/02/2016

Accepted: 11/04/2016

Online First: 25/04/2016

Published: 11/07/2016

Article revision time: 49 days

Article Online First time: 67 days

Article editing time: 144 days


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