Año 2018 / Volumen 110 / Número 5
Original
Fecal microbiota transplantation in refractory or recurrent Clostridium difficile infection: a real-life experience in a non-academic center

311-315

DOI: 10.17235/reed.2018.5099/2017

Ana Ponte, Rolando Pinho, Margarida Mota, Joana Silva, Nuno Vieira, Rosa Oliveira, Jaime Rodrigues, Mafalda Sousa, Isabel Sousa, João Carvalho,

Resumen
Aim: this study aimed to describe the efficacy and safety of fecal microbiota transplantation (FMT) for the treatment of refractory and recurrent Clostridium difficile infection (CDI). Methods: this was an observational study of patients with refractory or recurrent CDI treated with FMT between June 2014 and January 2017. Primary and secondary outcomes were the resolution of diarrhea without CDI recurrence within two months after one or more FMT. A descriptive analysis was performed. Results: thirty-four FMT were performed in 28 patients, 88.2% (n = 30) using an upper route with a gastroscopy and 11.8% (n = 4) with colonoscopy; 50% (n = 17) of FMT were due to recurrent CDI and 50% (n = 17) were due to refractory CDI. The overall cure rate of upper FMT was 87.5% (21/24) and 100% (4/4) when colonoscopy was performed. A cure was achieved after one FMT in 88% (22/25) of cases and after two or more FMT in 8% (2/25) of cases, resulting in an overall cure rate of 96% (24/25). No severe adverse events were reported. Conclusion: FMT constitutes an effective and safe approach for the management of refractory and recurrent CDI, with an overall cure rate of 96% and no reported severe adverse events.
Share Button
Nuevo comentario
Comentarios
No hay comentarios para este artículo.
Bibliografía
1) Gupta S, Allen-Vercoe E, Petrof EO. Fecal microbiota transplantation: in perspective. Therap Adv Gastroenterol. 2016 Mar;9(2):229-39.
2) Bakken JS, Borody T, Brandt LJ, et al. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol. 2011 Dec;9(12):1044-9.
3) Brandt LJ, Aroniadis OC, Mellow M, et al. Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection. Am J Gastroenterol. 2012 Jul;107(7):1079-87.
4) Brandt LJ, Aroniadis OC. An overview of fecal microbiota transplantation: techniques, indications, and outcomes. Gastrointest Endosc. 2013 Aug;78(2):240-9.
5) Rubin TA, Gessert CE, Aas J, et al. Fecal microbiome transplantation for recurrent Clostridium difficile infection: report on a case series. Anaerobe. 2013 Feb;19:22-6.
6) Choi HH, Cho YS. Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives. Clin Endosc. 2016 May;49(3):257-65.
7) Cammarota G, Ianiro G, Tilg H, et al. European consensus conference on faecal microbiota transplantation in clinical practice. Gut. 2017 Apr;66(4):569-580.
8) Cammarota G, Ianiro G, Gasbarrini A. Fecal microbiota transplantation for the treatment of Clostridium difficile infection: a systematic review. J Clin Gastroenterol. 2014 Sep;48(8):693-702.
9) Brandt LJ. American Journal of Gastroenterology Lecture: Intestinal microbiota and the role of fecal microbiota transplantation (FMT) in treatment of C. difficile infection. Am J Gastroenterol. 2013 Feb;108(2):177-85.
10) Kassam Z, Lee CH, Yuan Y, et al. Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis. Am J Gastroenterol. 2013 Apr;108(4):500-8.
11) van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med. 2013 Jan 31;368(5):407-15.
12) Postigo R, Kim JH. Colonoscopic versus nasogastric fecal transplantation for the treatment of Clostridium difficile infection: a review and pooled analysis. Infection. 2012 Dec;40(6):643-8.
13) Ponte A, Pinho R, Mota M, et al. Initial experience with fecal microbiota transplantation in Clostridium difficile infection - transplant protocol and preliminary results. Rev Esp Enferm Dig. 2015 Jul;107(7):402-7.
14) Surawicz CM, Brandt LJ, Binion DG, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol 2013;108(4): 478-98; quiz 499.
15) Newcombe, Robert G. "Two-Sided Confidence Intervals for the Single Proportion: Comparison of Seven Methods," Statistics in Medicine, 17, 857-872 (1998).
16) Wilson, E. B. "Probable Inference, the Law of Succession, and Statistical Inference," Journal of the American Statistical Association, 22, 209-212 (1927).
17) Li YT, Cai HF, Wang ZH, et al. Systematic review with meta-analysis: long-term outcomes of faecal microbiota transplantation for Clostridium difficile infection. Aliment Pharmacol Ther. 2016 Feb;43(4):445-57.
18) Borody T, Fischer M, Mitchell S, et al. Fecal microbiota transplantation in gastrointestinal disease: 2015 update and the road ahead. Expert Rev Gastroenterol Hepatol. 2015;9(11):1379-91.
19) Drekonja D, Reich J, Gezahegn S, et al. Fecal microbiota transplantation for clostridium difficile infection: a systematic review. Ann Intern Med 2015; 162: 630–8.
20) Rossen NG, MacDonald JK, de Vries EM, et al. Fecal microbiota transplantation as novel therapy in gastroenterology: a systematic review. W J Gastroenterol 2015; 21: 5359–71.
21) Gough E, Shaikh H, Manges AR. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent clostridium difficile infection. Clin Infect Dis 2011; 53: 994–1002.
22) Debast SB, Bauer MP, Kuijper EJ, et al. European Society of Clinical Microbiology and Infectious Diseases. European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. Infec Dis 2014;20(Suppl 2):1-26.
23) Smits LP, Bouter KE, de Vos WM, et al. Therapeutic potential of fecal microbiota transplantation. Gastroenterology. 2013 Nov;145(5):946-53.
24) Borody TJ, Khoruts A. Fecal microbiota transplantation and emerging applications. Nat Rev Gastroenterol Hepatol. 2011 Dec 20;9(2):88-96.
25) Youngster I, Russell GH, Pindar C, Ziv-Baran T, Sauk J, Hohmann EL. Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA. 2014 Nov 5;312(17):1772-8.
Artículos relacionados

Carta

Blue rubber bleb nevus syndrome

DOI: 10.17235/reed.2023.9913/2023

Carta

Calcifying fibrous tumor and pathological analysis

DOI: 10.17235/reed.2023.9739/2023

Carta

Endoscopic observation of a rare duodenal tumor

DOI: 10.17235/reed.2023.9679/2023

Carta

Linfoma MALT de colon: un desafío endoscópico

DOI: 10.17235/reed.2023.9595/2023

Carta

Isolated Jejunal Crohn's Disease: a challenging diagnosis

DOI: 10.17235/reed.2022.9423/2022

Carta

New technique for the endoscopic removal of long foreign bodies

DOI: 10.17235/reed.2023.9398/2022

Imagen en Patología Digestiva

Whipple’s disease – A typical endoscopic finding of a rare disease

DOI: 10.17235/reed.2022.9338/2022

Imagen en Patología Digestiva

A rare endoscopic pattern in a patient with gastroesophageal reflux disease

DOI: 10.17235/reed.2022.9124/2022

Imagen en Patología Digestiva

Esophageal tuberculosis

DOI: 10.17235/reed.2022.9108/2022

Imagen en Patología Digestiva

Esophagopleural fistula due to empyema necessitans

DOI: 10.17235/reed.2022.9085/2022

Imagen en Patología Digestiva

Pneumatosis intestinalis: a rare endoscopic feature of colonic ischemia

DOI: 10.17235/reed.2022.8980/2022

Carta

¿Melanoma intestinal primario?

DOI: 10.17235/reed.2022.8944/2022

Carta

Amiloidosis intestinal: un reto diagnóstico

DOI: 10.17235/reed.2022.8934/2022

Carta

Íleo biliar resuelto por endoscopia

DOI: 10.17235/reed.2022.8898/2022

Carta

Digestive tract MALT lymphoma, an unusual location

DOI: 10.17235/reed.2022.8800/2022

Imagen en Patología Digestiva

Metaplasia epidermoide de esófago: una entidad infrecuente

DOI: 10.17235/reed.2022.8708/2022

Imagen en Patología Digestiva

Tumor neuroendocrino ileal como causa infrecuente de hemorragia digestiva de origen oscuro

DOI: 10.17235/reed.2022.8641/2022

Imagen en Patología Digestiva

A case of duodenal-type follicular lymphoma

DOI: 10.17235/reed.2021.8233/2021

Imagen en Patología Digestiva

Endoscopic resection of a duodenal neuroendocrine tumor

DOI: 10.17235/reed.2021.8232/2021

Imagen en Patología Digestiva

Duodenal-type follicular lymphoma: a silent tumor

DOI: 10.17235/reed.2021.8149/2021

Imagen en Patología Digestiva

Neumatosis intestinal idiopática o primaria: un hallazgo casual endoscópico poco frecuente

DOI: 10.17235/reed.2021.8049/2021

Carta

Bochdalek hernia: use of capsule endoscopy

DOI: 10.17235/reed.2021.7760/2020

Imagen en Patología Digestiva

Endoscopic forceps removal for complicated magnetic beads impaction

DOI: 10.17235/reed.2021.7731/2020

Imagen en Patología Digestiva

Afectación ampollosa esofágica por pénfigo vulgar

DOI: 10.17235/reed.2020.7417/2020

Revisión

Advanced therapy by device-assisted enteroscopy

DOI: 10.17235/reed.2020.6971/2020

Carta

Luetic gastritis: an uncommon cause of gastritis

DOI: 10.17235/reed.2020.6870/2020

Carta

Úlcera gástrica por mucormicosis en paciente crítico

DOI: 10.17235/reed.2020.6636/2019

Carta

Esophagogastroduodenoscopy: how far should we go? Point of view

DOI: 10.17235/reed.2019.6585/2019

Carta

Coriocarcinoma gástrico primario

DOI: 10.17235/reed.2020.6478/2019

Imagen en Patología Digestiva

Jejunal schwannoma detected by video capsule endoscopy

DOI: 10.17235/reed.2020.6474/2019

Imagen en Patología Digestiva

Capsule endoscopy, a useful tool for the diagnosis of a tapeworm infection

DOI: 10.17235/reed.2019.6346/2019

Editorial

Unidades de endoscopia, statu quo

DOI: 10.17235/reed.2019.6347/2019

Carta

Mastocitosis sistémica diagnosticada endoscópicamente

DOI: 10.17235/reed.2019.6246/2019

Imagen en Patología Digestiva

A rare heterotopic gastric mucosa appearing between the muscularis mucosae and submucosa

DOI: 10.17235/reed.2019.6134/2018

Artículo Especial

Indicadores de calidad en gastroscopia. Procedimiento de la gastroscopia

DOI: 10.17235/reed.2019.6023/2018

Carta

Manejo endoscópico del síndrome de Boerhaave

DOI: 10.17235/reed.2019.6013/2018

Imagen en Patología Digestiva

Neoplasia papilar mucinosa intraductal de conducto principal en un paciente con páncreas divisum

DOI: 10.17235/reed.2019.5959/2018

Carta

Use of patency capsule in daily practice

DOI: 10.17235/reed.2019.5952/2018

Carta

Symptomatic exfoliative esophagitis induced by dabigatran

DOI: 10.17235/reed.2018.5747/2018

Artículo Especial

Endoscopia y sedación: un binomio inseparable para el gastroenterólogo

DOI: 10.17235/reed.2018.5585/2018

Imagen en Patología Digestiva

Dysphagia and hematemesis caused by an intramural esophageal dissection

DOI: 10.17235/reed.2018.5471/2018

Imagen en Patología Digestiva

Metástasis de dermatofibrosarcoma diagnosticada mediante cápsula endoscópica

DOI: 10.17235/reed.2018.4900/2017

Carta al Editor

Retención sintomática de cápsula degradable Agile®

DOI: 10.17235/reed.2017.4691/2016

Carta al Editor

Ball valve syndrome caused by a giant gastric Vanek’s tumor

DOI: 10.17235/reed.2017.4526/2016

Original

Estudio multicéntrico de seguridad en endoscopia bariátrica

DOI: 10.17235/reed.2017.4499/2016

Carta al Editor

Extracción endoscópica de paquete de hachís

DOI: 10.17235/reed.2017.4504/2016

Carta al Editor

Whipple’s disease under the vision of capsule endoscopy

DOI: 10.17235/reed.2016.4362/2016

Carta al Editor

About human taeniasis and Taenia saginata diagnosis by endoscopy

DOI: 10.17235/reed.2016.4297/2016

Imagen en Patología Digestiva

Jejunal metastasis of renal cell carcinoma

Carta al Editor

Resección endoscópica submucosa transanal (TASER) mediante sistema TEO

DOI: 10.17235/reed.2016.4154/2015

Caso Clínico

Diagnóstico atípico mediante cápsula endoscópica: enfermedad de Whipple

DOI: 10.17235/reed.2015.3718/2015

Instrucciones para citar
Ponte A, Pinho R, Mota M, Silva J, Vieira N, Oliveira R, et all. Fecal microbiota transplantation in refractory or recurrent Clostridium difficile infection: a real-life experience in a non-academic center. 5099/2017


Descargar en un gestor de citas

Descargue la cita de este artículo haciendo clic en uno de los siguientes gestores de citas:

Métrica
Este artículo ha sido visitado 836 veces.
Este artículo ha sido descargado 304 veces.

Estadísticas de Dimensions


Estadísticas de Plum Analytics

Ficha Técnica

Recibido: 02/06/2017

Aceptado: 15/12/2017

Prepublicado: 07/02/2018

Publicado: 27/04/2018

Tiempo de revisión del artículo: 192 días

Tiempo de prepublicación: 250 días

Tiempo de edición del artículo: 329 días


Compartir
Este artículo aun no tiene valoraciones.
Valoración del lector:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
La REED es el órgano oficial de la Sociedad Española de Patología Digestiva, la SociedadEspañola de Endoscopia Digestiva y la Asociación Española de Ecografía Digestiva
Política de cookies Política de Privacidad Aviso Legal © Copyright 2023 y Creative Commons. Revista Española de Enfermedades Digestivas