REED - Revista Española de Enfermedades Digestivas

New issue alert	Contact
Submit a manuscript	Follow REEDigestivas_
Versión en español

Year 2025 / Volume 117 / Number 5
Original

LncRNA OIP5-AS1 mediated miR-28-5p provides promising support for the diagnosis and prognosis of cholangiocarcinoma

256-264

DOI: 10.17235/reed.2024.10632/2024

Yanqing Gong, Huimin Wang, Xiaoming Wang, Deli Kuang, Chunmiao Yuan, Jianhua Ju,

Abstract

Background: long non-coding RNAs (lncRNAs) are a major research focus in a variety of diseases, and lncRNA OIP5-AS1 (OIP5-AS1) was shown to mediate the progression of various tumors. This article discusses how OIP5-AS1 could potentially be used to diagnose and prognosticate cholangiocarcinoma (CHOL). Methods: the ENROCI project evaluated OIP5-AS1 expression in CHOL samples, which was confirmed by RT-qPCR. A bioinformatics database predicted the target gene of OIP5-AS1 in CHOL, which was then confirmed by luciferase activity assays. The CCK-8 and Transwell methods were employed to detect the changes in CHOL cell growth and migration levels after OIP5-AS1 knockdown. ROC and Kaplan-Meier curves were used to examine the diagnostic and prognostic functions of OIP5-AS1. Results: in CHOL tissues and cells, OIP5-AS1 was enhanced compared to the controls. Reducing OIP5-AS1 hampered the regulatory capacity of CHOL cells, which was restored by the miR-28-5p inhibitor. Notably, OIP5-AS1 was observed to sponge and downregulate miR-28-5p, exhibiting high sensitivity and specificity (84.4 % and 81.3 %) in CHOL. G3BP1 was a direct target of miR-28-5p. Decreased OIP5-AS1 level was beneficial for survival (HR = 2.391, p = 0.024). Conclusion: OIP5-AS1 targets and negatively mediates miR-28-5p/G3BP1 axis to promote the activity of CHOL cells, which may be a potential marker for diagnosis and prognosis of CHOL patients.

Lay Summary

Long non-coding RNAs are a major research focus in a variety of diseases, and lncRNA OIP5-AS1 (OIP5-AS1) was shown to mediate the progression of various tumors. This paper discusses how OIP5-AS1 could potentially be used to diagnose and prognosticate cholangiocarcinoma. In our study, OIP5-AS1 expression was upregulated in cholangiocarcinoma tissues and cells, and was related to shorter survival time. OIP5-AS1 targets and negatively mediates miR-28-5p/G3BP1 axis to promote the activity of cholangiocarcinoma cells, which may be a potential marker for diagnosis and prognosis of cholangiocarcinoma patients.

New comment

Comments

No comments for this article

References

1. Guo K, Lou Y, Zheng S. Predictors of Distant Metastasis and Prognosis in Newly Diagnosed T1 Intrahepatic Cholangiocarcinoma. BioMed research international. 2023;2023:6638755.

DOI: 10.1155/2023/6638755

2. Wang K, Zhang Y, Yang X, Chen T, Han T. Analysis of differentially expressed mRNAs and the prognosis of cholangiocarcinoma based on TCGA database. Translational cancer research. 2020;9(8):4739-49.

DOI: 10.21037/tcr-20-812

3. Zhu H, Zhao H, Wang J, Zhao S, Ma C, Wang D, et al. Potential prognosis index for m(6)A-related mRNA in cholangiocarcinoma. BMC cancer. 2022;22(1):620.

DOI: 10.1186/s12885-022-09665-3

4. Xie Y, Zhang H, Guo XJ, Feng YC, He RZ, Li X, et al. Let-7c inhibits cholangiocarcinoma growth but promotes tumor cell invasion and growth at extrahepatic sites. Cell death & disease. 2018;9(2):249.

DOI: 10.1038/s41419-018-0286-6

5. Lin W, Zhou Q, Wang CQ, Zhu L, Bi C, Zhang S, et al. LncRNAs regulate metabolism in cancer. International journal of biological sciences. 2020;16(7):1194-206.

DOI: 10.7150/ijbs.40769

6. Baruah C, Nath P, Barah P. LncRNAs in neuropsychiatric disorders and computational insights for their prediction. Molecular biology reports. 2022;49(12):11515-34.

DOI: 10.1007/s11033-022-07819-x

7. Li W, Wang Q, Feng Q, Wang F, Yan Q, Gao SJ, et al. Oncogenic KSHV-encoded interferon regulatory factor upregulates HMGB2 and CMPK1 expression to promote cell invasion by disrupting a complex lncRNA-OIP5-AS1/miR-218-5p network. PLoS pathogens. 2019;15(1):e1007578.

DOI: 10.1371/journal.ppat.1007578

8. Zhong J, Chen J, Wang B, Zhou Z, Shen Y, Gong Y, et al. OIP5-AS1: A Fascinating Long Noncoding RNA in Carcinoma. Current pharmaceutical design. 2021;27(46):4699-706.

DOI: 10.2174/1381612827666210927105558

9. Li Y, Han X, Feng H, Han J. Long noncoding RNA OIP5-AS1 in cancer. Clinica chimica acta; international journal of clinical chemistry. 2019;499:75-80.

DOI: 10.1016/j.cca.2019.08.031

10. Pronina IV, Filippova EA, Brovkina OI, Burdennyy AM, Kazubskaya TP, Kushlinskii DN, et al. Long Non-Coding RNAs and microRNAs Groups in the Regulation of Expression Level of a Number of Tumor-Associated Genes in Ovarian Cancer. Bulletin of experimental biology and medicine. 2023;174(3):354-9.

DOI: 10.1007/s10517-023-05707-3

11. Qin GH, Yang WC, Yao JN, Zhao Y, Wu XJ. LncRNA OIP5-AS1 affects the biological behaviors of chondrocytes of patients with osteoarthritis by regulating micro-30a-5p. European review for medical and pharmacological sciences. 2021;25(3):1215-24.

12. Li Y, Liu L. LncRNA OIP5-AS1 Signatures as a Biomarker of Gestational Diabetes Mellitus and a Regulator on Trophoblast Cells. Gynecologic and obstetric investigation. 2021;86(6):509-17.

DOI: 10.1159/000520340

13. Yang J, Huang Q, Liao P, Zhang P, Sun S, Xu Q. Mechanism of miR-338-3p in sepsis-induced acute lung injury via indirectly modulating ATF4. Transplant immunology. 2023;76:101681.

DOI: 10.1016/j.trim.2022.101681

14. Cuzziol CI, Marzochi LL, Possebon VS, Kawasaki-Oyama RS, Mattos MF, Junior VS, et al. Regulation of VEGFA, KRAS, and NFE2L2 Oncogenes by MicroRNAs in Head and Neck Cancer. International journal of molecular sciences. 2022;23(13).

DOI: 10.3390/ijms23137483

15. Ghafouri-Fard S, Khoshbakht T, Hussen BM, Taheri M, Samadian M. A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression. Cancer cell international. 2022;22(1):225.

DOI: 10.1186/s12935-022-02644-5

16. You Z, Liu C, Wang C, Ling Z, Wang Y, Wang Y, et al. LncRNA CCAT1 Promotes Prostate Cancer Cell Proliferation by Interacting with DDX5 and MIR-28-5P. Molecular cancer therapeutics. 2019;18(12):2469-79.

DOI: 10.1158/1535-7163.MCT-19-0095

17. Pausawasdi N, Termsinsuk P, Charatcharoenwitthaya P, Limsrivilai J, Kaosombatwattana U. Development and validation of a risk score for predicting clinical success after endobiliary stenting for malignant biliary obstruction. PloS one. 2022;17(8):e0272918.

DOI: 10.1371/journal.pone.0272918

18. Ji Y, Yan T, Zhu S, Wu R, Zhu M, Zhang Y, et al. The Integrative Analysis of Competitive Endogenous RNA Regulatory Networks in Coronary Artery Disease. Frontiers in cardiovascular medicine. 2021;8:647953.

DOI: 10.3389/fcvm.2021.647953

19. Yang K, Zeng L, Ge A, Wang S, Zeng J, Yuan X, et al. A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury. Frontiers in immunology. 2022;13:930171.

DOI: 10.3389/fimmu.2022.930171

20. Wu Z, Liu Y, Wei L, Han M. LncRNA OIP5-AS1 Promotes Breast Cancer Progression by Regulating miR-216a-5p/GLO1. The Journal of surgical research. 2021;257:501-10.

DOI: 10.1016/j.jss.2020.07.067

21. Guo L, Chen J, Liu D, Liu L. OIP5-AS1/miR-137/ZNF217 Axis Promotes Malignant Behaviors in Epithelial Ovarian Cancer. Cancer management and research. 2020;12:6707-17.

DOI: 10.2147/CMAR.S237726

22. Wan T, Wang H, Gou M, Si H, Wang Z, Yan H, et al. LncRNA HEIH promotes cell proliferation, migration and invasion in cholangiocarcinoma by modulating miR-98-5p/HECTD4. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020;125:109916.

DOI: 10.1016/j.biopha.2020.109916

23. Lu M, Qin X, Zhou Y, Li G, Liu Z, Yue H, et al. LncRNA HOTAIR suppresses cell apoptosis, autophagy and induces cell proliferation in cholangiocarcinoma by modulating the miR-204-5p/HMGB1 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020;130:110566.

DOI: 10.1016/j.biopha.2020.110566

24. Liu Y, Guo C, Li F, Wu L. LncRNA LOXL1-AS1/miR-28-5p/SEMA7A axis facilitates pancreatic cancer progression. Cell biochemistry and function. 2020;38(1):58-65.

DOI: 10.1002/cbf.3449

25. Wu L, Zhu X, Wang R, Sun S, Ma B, Zhang Z. The AKT/mTOR Signaling Pathway Was Mediated through the LINC00514/miR-28-5p/TRIM44 Axis. Disease markers. 2022;2022:1889467.

DOI: 10.1155/2022/1889467

26. Chen T, Wang H, Yan H. miR-28-5p inhibits cholangiocarcinoma progression and predicts good prognosis of patients. Cell cycle (Georgetown, Tex). 2022;21(19):2079-90.

DOI: 10.1080/15384101.2022.2085359

27. Xu R, Guo Q, Zhao P, Lu H, Zhang B. miR-28-5p's Targeting of GAGE12I Inhibits Proliferation, Migration, and Invasion of Gastric Cancer in Vitro. Evidence-based complementary and alternative medicine : eCAM. 2022;2022:6946051.

DOI: 10.1155/2022/6946051

28. Ma L, Zhang Y, Hu F. miR‑28‑5p inhibits the migration of breast cancer by regulating WSB2. International journal of molecular medicine. 2020;46(4):1562-70.

DOI: 10.3892/ijmm.2020.4685

29. Zhang L, Wang X, Liu X, Lv M, Shen E, Zhu G, et al. miR-28-5p targets MTSS1 to regulate cell proliferation and apoptosis in esophageal cancer. Acta biochimica et biophysica Sinica. 2020;52(8):842-52.

DOI: 10.1093/abbs/gmaa059

30. Zhao W, Zhao J, Guo X, Feng Y, Zhang B, Tian L. LncRNA MT1JP plays a protective role in intrahepatic cholangiocarcinoma by regulating miR-18a-5p/FBP1 axis. BMC cancer. 2021;21(1):142.

DOI: 10.1186/s12885-021-07838-0

31. Wu T, Lei MS, Gao XZ, Xiong TG, Yang K, Gong Q, et al. lncRNA SNHG16 Mediates Cell Proliferation and Apoptosis in Cholangiocarcinoma by Directly Targeting miR-146a-5p/GATA6 Axis. Biochemical genetics. 2021;59(5):1311-25.

DOI: 10.1007/s10528-021-10059-6

32. Guan C, Zhao Y, Wang W, Hu Z, Liu L, Li W, et al. Knockdown of lncRNA SNHG20 Suppressed the Proliferation of Cholangiocarcinoma by Sponging miR-520f-3p. Cancer biotherapy & radiopharmaceuticals. 2020.

33. Wu L, Yang J, Ke RS, Liu Y, Guo P, Feng L, et al. Impact of lncRNA SOX9-AS1 overexpression on the prognosis and progression of intrahepatic cholangiocarcinoma. Clinics and research in hepatology and gastroenterology. 2022;46(9):101999.

DOI: 10.1016/j.clinre.2022.101999

1. Guo K, Lou Y, Zheng S. Predictors of Distant Metastasis and Prognosis in Newly Diagnosed T1 Intrahepatic Cholangiocarcinoma. BioMed research international. 2023;2023:6638755.

DOI: 10.1155/2023/6638755

2. Wang K, Zhang Y, Yang X, Chen T, Han T. Analysis of differentially expressed mRNAs and the prognosis of cholangiocarcinoma based on TCGA database. Translational cancer research. 2020;9(8):4739-49.

DOI: 10.21037/tcr-20-812

3. Zhu H, Zhao H, Wang J, Zhao S, Ma C, Wang D, et al. Potential prognosis index for m(6)A-related mRNA in cholangiocarcinoma. BMC cancer. 2022;22(1):620.

DOI: 10.1186/s12885-022-09665-3

DOI: 10.1038/s41419-018-0286-6

5. Lin W, Zhou Q, Wang CQ, Zhu L, Bi C, Zhang S, et al. LncRNAs regulate metabolism in cancer. International journal of biological sciences. 2020;16(7):1194-206.

DOI: 10.7150/ijbs.40769

6. Baruah C, Nath P, Barah P. LncRNAs in neuropsychiatric disorders and computational insights for their prediction. Molecular biology reports. 2022;49(12):11515-34.

DOI: 10.1007/s11033-022-07819-x

DOI: 10.1371/journal.ppat.1007578

8. Zhong J, Chen J, Wang B, Zhou Z, Shen Y, Gong Y, et al. OIP5-AS1: A Fascinating Long Noncoding RNA in Carcinoma. Current pharmaceutical design. 2021;27(46):4699-706.

DOI: 10.2174/1381612827666210927105558

9. Li Y, Han X, Feng H, Han J. Long noncoding RNA OIP5-AS1 in cancer. Clinica chimica acta; international journal of clinical chemistry. 2019;499:75-80.

DOI: 10.1016/j.cca.2019.08.031

DOI: 10.1007/s10517-023-05707-3

12. Li Y, Liu L. LncRNA OIP5-AS1 Signatures as a Biomarker of Gestational Diabetes Mellitus and a Regulator on Trophoblast Cells. Gynecologic and obstetric investigation. 2021;86(6):509-17.

DOI: 10.1159/000520340

13. Yang J, Huang Q, Liao P, Zhang P, Sun S, Xu Q. Mechanism of miR-338-3p in sepsis-induced acute lung injury via indirectly modulating ATF4. Transplant immunology. 2023;76:101681.

DOI: 10.1016/j.trim.2022.101681

DOI: 10.3390/ijms23137483

15. Ghafouri-Fard S, Khoshbakht T, Hussen BM, Taheri M, Samadian M. A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression. Cancer cell international. 2022;22(1):225.

DOI: 10.1186/s12935-022-02644-5

DOI: 10.1158/1535-7163.MCT-19-0095

DOI: 10.1371/journal.pone.0272918

DOI: 10.3389/fcvm.2021.647953

DOI: 10.3389/fimmu.2022.930171

20. Wu Z, Liu Y, Wei L, Han M. LncRNA OIP5-AS1 Promotes Breast Cancer Progression by Regulating miR-216a-5p/GLO1. The Journal of surgical research. 2021;257:501-10.

DOI: 10.1016/j.jss.2020.07.067

21. Guo L, Chen J, Liu D, Liu L. OIP5-AS1/miR-137/ZNF217 Axis Promotes Malignant Behaviors in Epithelial Ovarian Cancer. Cancer management and research. 2020;12:6707-17.

DOI: 10.2147/CMAR.S237726

DOI: 10.1016/j.biopha.2020.109916

DOI: 10.1016/j.biopha.2020.110566

24. Liu Y, Guo C, Li F, Wu L. LncRNA LOXL1-AS1/miR-28-5p/SEMA7A axis facilitates pancreatic cancer progression. Cell biochemistry and function. 2020;38(1):58-65.

DOI: 10.1002/cbf.3449

25. Wu L, Zhu X, Wang R, Sun S, Ma B, Zhang Z. The AKT/mTOR Signaling Pathway Was Mediated through the LINC00514/miR-28-5p/TRIM44 Axis. Disease markers. 2022;2022:1889467.

DOI: 10.1155/2022/1889467

26. Chen T, Wang H, Yan H. miR-28-5p inhibits cholangiocarcinoma progression and predicts good prognosis of patients. Cell cycle (Georgetown, Tex). 2022;21(19):2079-90.

DOI: 10.1080/15384101.2022.2085359

DOI: 10.1155/2022/6946051

28. Ma L, Zhang Y, Hu F. miR‑28‑5p inhibits the migration of breast cancer by regulating WSB2. International journal of molecular medicine. 2020;46(4):1562-70.

DOI: 10.3892/ijmm.2020.4685

DOI: 10.1093/abbs/gmaa059

30. Jiang W, Wang J, Yang X, Shan J, Zhang Y, Shi X, et al. KIF14 promotes proliferation, lymphatic metastasis and chemoresistance through G3BP1/YBX1 mediated NF-κB pathway in cholangiocarcinoma. Oncogene. 2023;42(17):1392-404.

DOI: 10.1038/s41388-023-02661-2

31. Wang L, Yi J, Lu LY, Zhang YY, Wang L, Hu GS, et al. Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes. Theranostics. 2021;11(4):1732-52.

DOI: 10.7150/thno.45302

32. Wu T, Lei MS, Gao XZ, Xiong TG, Yang K, Gong Q, et al. lncRNA SNHG16 Mediates Cell Proliferation and Apoptosis in Cholangiocarcinoma by Directly Targeting miR-146a-5p/GATA6 Axis. Biochemical genetics. 2021;59(5):1311-25.

DOI: 10.1007/s10528-021-10059-6

33. Guan C, Zhao Y, Wang W, Hu Z, Liu L, Li W, et al. Knockdown of lncRNA SNHG20 Suppressed the Proliferation of Cholangiocarcinoma by Sponging miR-520f-3p. Cancer biotherapy & radiopharmaceuticals. 2020.

34. Wu L, Yang J, Ke RS, Liu Y, Guo P, Feng L, et al. Impact of lncRNA SOX9-AS1 overexpression on the prognosis and progression of intrahepatic cholangiocarcinoma. Clinics and research in hepatology and gastroenterology. 2022;46(9):101999.

DOI: 10.1016/j.clinre.2022.101999

Editorial

Diagnosing hilar cholangiocarcinoma: ERCP with cholangioscopy

DOI: 10.17235/reed.2025.11051/2024

Original

Genetic map of Wilson disease in Spain - A great tool to improve diagnosis and screening

DOI: 10.17235/reed.2025.11005/2024

Letter

Deceiving duodenal erosion: a fishbone lies beneath

DOI: 10.17235/reed.2024.10872/2024

Original

Acceptable number of cholangioscopy-guided biopsies for diagnosing perihilar cholangiocarcinoma

DOI: 10.17235/reed.2024.10719/2024

Letter

Immune cholangitis related to anti-programmed cell death and programmed cell death ligand agents for the treatment of intrahepatic cholangiocarcinoma

DOI: 10.17235/reed.2024.10284/2024

Letter

Lymphoepithelioma-like cholangiocarcinoma mimicking hepatocellular carcinoma

DOI: 10.17235/reed.2023.10079/2023

Letter

Recurrent hemobilia secondary to extrahepatic biliary tract cholangiocarcinoma. A diagnostic challenge

DOI: 10.17235/reed.2023.9922/2023

Letter

Pancreatic schwannomaPancreatic schwannoma: a rare tumor of the pancreasa rare tumor of the pancreas

DOI: 10.17235/reed.2023.9840/2023

Letter

Dissemination of the automated alert system in the diagnosis and treatment of hepatitis C

DOI: 10.17235/reed.2023.9801/2023

Letter

Calcifying fibrous tumor and pathological analysis

DOI: 10.17235/reed.2023.9739/2023

Letter

Stage IV perihilar cholangiocarcinoma with loss of expression of MSH2 and MSH6: hereditary cancer syndrome?

DOI: 10.17235/reed.2023.9724/2023

Letter

Pancreaticobiliary maljunction induced cholangiocarcinoma after gallbladder cancer

DOI: 10.17235/reed.2023.9715/2023

Letter

Endoscopic observation of a rare duodenal tumor

DOI: 10.17235/reed.2023.9679/2023

Editorial

Recent advances in the diagnosis and management of Wilson’s disease

DOI: 10.17235/reed.2023.9633/2023

Letter

Paraneoplastic acquired hemophilia A associated with hilar cholangiocarcinoma arising in an intraductal papillary neoplasm of the bile duct

DOI: 10.17235/reed.2023.9562/2023

Letter

Bile duct schwannoma, an uncommon cause of a bile duct tumor, diagnosis and therapeutic management

DOI: 10.17235/reed.2023.9443/2022

Letter

Vaginal lesion as first manifestation of colorectal disease

DOI: 10.17235/reed.2022.9270/2022

Letter

Hilar cholangiocarcinoma presenting with hematochezia due to metastases to the rectum

DOI: 10.17235/reed.2022.9173/2022

Letter

Intrahepatic sarcomatoid cholangiocarcinoma: a rare cholangiocarcinoma subtype

DOI: 10.17235/reed.2022.9130/2022

Digestive Diseases Image

High-grade intraepithelial neoplasia of the cervical esophagus arising from a tiny ectopic gastric mucosa

DOI: 10.17235/reed.2022.9007/2022

Letter

Bronchial-biliary fistula secondary to cholangiocarcinoma: long-term efficacy of biliary self-expandable metal stent

DOI: 10.17235/reed.2022.8970/2022

Letter

Importance of immunohistochemistry in the differential diagnosis of gastric mesenchymal tumors

DOI: 10.17235/reed.2022.8923/2022

Letter

Diagnosis and treatment of a small intestinal neuroendocrine neoplasm by double balloon enteroscopy combined with laparoscopy: a case report

DOI: 10.17235/reed.2022.8900/2022

Letter

Extensive intramural hematoma of the esophagus: a rare complication of esophageal thermal injury

DOI: 10.17235/reed.2022.8861/2022

Original

Relationship between DHX15 expression and survival in colorectal cancer

DOI: 10.17235/reed.2022.8838/2022

Letter

An uncommon case of gastrointestinal bleeding: Meckel’s diverticulum with ectopic gastric mucosa

DOI: 10.17235/reed.2022.8831/2022

Letter

Impact of the SARS-CoV-2 pandemic on pancreatic cancer: diagnosis and short-term survival

DOI: 10.17235/reed.2022.8772/2022

Digestive Diseases Image

An unusual cause of a protuberant lesion of the gastric antrum

DOI: 10.17235/reed.2022.8771/2022

Letter

Altered Expression of TMEM16A in Colorectal Carcinoma and Its Clinical Significance

DOI: 10.17235/reed.2022.8756/2022

Letter

Sigmoid colon Schwannoma simulating colon cancer

DOI: 10.17235/reed.2022.8684/2022

Original

Comparison of diagnostic accuracy between linear EUS and miniprobe EUS for submucosal invasion in suspected cases of early gastric cancer.

DOI: 10.17235/reed.2022.8512/2021

Original

EUS-guided fine-needle liver biopsy in pediatric patients using a modified technique with one-pass, one-actuation wet suction

DOI: 10.17235/reed.2022.8503/2021

Review

Prognostic analysis of Yes-associated protein 1 in patients with colorectal cancer. A systematic review and meta-analysis

DOI: 10.17235/reed.2022.8472/2021

Original

A slowdown of hepatitis C diagnosis in high-prevalence groups and with decentralized diagnostic strategies during the COVID-19 pandemic

DOI: 10.17235/reed.2022.8412/2021

Original

TMEM16A overexpression indicates poor prognosis in colorectal cancer patients

DOI: 10.17235/reed.2021.8292/2021

Digestive Diseases Image

Malignancy of intraductal papillary neoplasm of the bile duct

DOI: 10.17235/reed.2021.8193/2021

Digestive Diseases Image

Abdominal cocoon sign: an unusual cause of intestinal obstruction

DOI: 10.17235/reed.2021.8057/2021

Letter

POEMS syndrome: an uncommon cause of peritoneal effusion

DOI: 10.17235/reed.2021.8027/2021

Original

Abnormal liver chemistry constitutes an independent prognostic factor of less favorable clinical course in patients with COVID-19

DOI: 10.17235/reed.2021.7842/2021

Original

High expression of NDRG3 correlates with poor prognosis in gastric cancer patients

DOI: 10.17235/reed.2021.7723/2020

Original

Low applicability of the ‘‘Six-and-twelve score” in hepatocellular carcinoma treated with Drug-Eluting Beads Transarterial Chemoembolization.

DOI: 10.17235/reed.2021.7696/2020

Original

Detection of anti-kelch-like 12 and anti-hexokinase 1 antibodies in primary biliary cholangitis patients in China

DOI: 10.17235/reed.2020.7483/2020

Digestive Diseases Image

Phlebosclerotic colitis: an unusual cause of abdominal pain and hematochezia

DOI: 10.17235/reed.2020.7358/2020

Digestive Diseases Image

Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of a case of a huge abdominal mass

DOI: 10.17235/reed.2020.7305/2020

Original

Can we optimize CEA as a response marker in rectal cancer?

DOI: 10.17235/reed.2020.7321/2020

Review

New non-invasive biomarkers for colorectal cancer screening

DOI: 10.17235/reed.2020.7233/2020

Original

Role of endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and classification of lymphomas

DOI: 10.17235/reed.2020.7191/2020

Letter

It seems like cholangiocarcinoma but it is not: discovering the choledochal cyst

DOI: 10.17235/reed.2020.7114/2020

Editorial

Reflex testing. A key tool for the elimination of hepatitis C

DOI: 10.17235/reed.2020.7201/2020

Letter

Pseudoaneurysm of the gastroduodenal artery with arterio-duodenal fistulization secondary to acute pancreatitis: an unusual endoscopic diagnosis

DOI: 10.17235/reed.2020.7070/2020

Letter

Chilaiditi’s and Ogilvie syndromes

DOI: 10.17235/reed.2020.7036/2020

Original

Efficacy and safety of radiofrequency ablation in patients with unresectable malignant biliary strictures

DOI: 10.17235/reed.2020.7023/2020

Original

Percutaneous transhepatic cholangiography and drainage and endoscopic retrograde cholangiopancreatograph for hilar cholangiocarcinoma: which one is preferred?

DOI: 10.17235/reed.2020.6937/2020

Letter

Hepatocarcinoma diagnosis. Reflection is required

DOI: 10.17235/reed.2020.6845/2019

Special Article

Principles for implementing a population screening strategy for hepatitis C in Spain

DOI: 10.17235/reed.2019.6768/2019

Original

Differences between residual and primary choledocholithiasis in cholecystectomy patients

DOI: 10.17235/reed.2020.6760/2019

Original

Surgical management of Boerhaave’s syndrome with early and delayed diagnosis in adults: a retrospective study of 88 patients

DOI: 10.17235/reed.2020.6746/2019

Special Article

Elimination of hepatitis C. Positioning document of the Spanish Association for the Study of the Liver (AEEH)

DOI: 10.17235/reed.2019.6700/2019

Original

Elevated serum levels of interleukin-37 correlate with poor prognosis in gastric cancer

DOI: 10.17235/reed.2019.6460/2019

Original

Elevated high mobility group A2 expression in liver cancer predicts poor patient survival

DOI: 10.17235/reed.2019.6365/2019

Case Report

Endoluminal radiofrequency ablation with SpyGlass™ in the management of cholangiocarcinoma

DOI: 10.17235/reed.2019.6230/2019

Original

Prognostic value of serum high-density lipoprotein cholesterol in patients with gallbladder cancer

DOI: 10.17235/reed.2019.6201/2019

Original

The effect of marital status on the survival of patients with colorectal neuroendocrine neoplasms: an analysis of the SEER database

DOI: 10.17235/reed.2019.6183/2019

Original

Prognostic influence of CDX2 expression in gastric carcinoma after surgery with a curative intent

DOI: 10.17235/reed.2019.5976/2018

Review

Meta-analysis of the diagnostic value of contrast-enhanced ultrasound for the detection of vascular complications after liver transplantation

DOI: 10.17235/reed.2018.5818/2018

Original

The efficiency of several one-step testing strategies for the diagnosis of hepatitis C

DOI: 10.17235/reed.2018.5810/2018

Original

First hospital contact via the Emergency Department is an independent predictor of overall survival and disease-free survival in patients with colorectal cancer

DOI: 10.17235/reed.2019.5777/2018

Original

Klatskin tumors and “Klatskin-mimicking lesions”: our 22-year experience.

DOI: 10.17235/reed.2018.5749/2018

Letter

An unusual case report of inflammatory fibrous polyps in the upper gastrointestinal tract

DOI: 10.17235/reed.2018.5734/2018

Original

Analysis of rebleeding in cases of an upper gastrointestinal bleed in a single center series

DOI: 10.17235/reed.2018.5702/2018

Original

Primary biliary cholangitis in Spain. Results of a Delphi study of epidemiology, diagnosis, follow-up and treatment

DOI: 10.17235/reed.2018.5665/2018

Review

Meckel’s diverticulum: clinical features, diagnosis and management

DOI: 10.17235/reed.2018.5628/2018

Case Report

Endoscopic closure of tracheoesophageal fistula for tuberculosis with an over-the-scope-clip

DOI: 10.17235/reed.2018.5563/2018

Editorial

The right colon challenge

DOI: 10.17235/reed.2018.5544/2018

Original

Long noncoding RNAs as diagnostic biomarkers for the early detection of digestive tract cancers: a systematic review and meta-analysis

DOI: 10.17235/reed.2020.5450/2018

Original

Endoscopic ultrasound cytologic brushing vs endoscopic ultrasound - fine needle aspiration for cytological diagnosis of cystic pancreatic lesions. A multicenter, randomized open-label trial

DOI: 10.17235/reed.2018.5449/2017

Original

Analysis of the diagnostic yield of endoscopic ultrasonography-guided fine-needle aspiration in patients with a suspected pancreatic malignancy

DOI: 10.17235/reed.2018.5455/2017

Special Article

Recommendations to report and interpret HLA genetic findings in coeliac disease

DOI: 10.17235/reed.2018.5269/2017

Original

Gastrointestinal stromal tumors: 16 years’ experience within a university hospital

DOI: 10.17235/reed.2018.5199/2017

Review

Intestinal tuberculosis and Crohn’s disease: the importance and difficulty of a differential diagnosis

DOI: 10.17235/reed.2018.5184/2017

Letter to the Editor

Neuroendocrine tumors of the pancreas: keys issues in dealing with heterogeneity

DOI: 10.17235/reed.2017.4997/2017

Letter to the Editor

Pancreatic neuroendocrine tumors. Prognostic factors

DOI: 10.17235/reed.2017.5109/2017

Letter to the Editor

Sternal cutaneous metastasis of hilar cholangiocarcinoma

DOI: 10.17235/reed.2017.4979/2017

Original

Clinical manifestations and endoscopic presentations of gastric lymphoma: a multicenter seven year retrospective survey

DOI: 10.17235/reed.2017.4882/2017

Case Report

Intraductal papillary neoplasia of the bile duct with malignancy: a differentiated entity of cholangiocarcinoma with a better prognosis. A review of three new cases

DOI: 10.17235/reed.2017.4835/2016

Editorial

Pancreas neuroendocrine tumors - not so rare or benign

DOI: 10.17235/reed.2016.4672/2016

Original

Matrix metalloproteases expression in different histological types of colorectal polyps

DOI: 10.17235/reed.2017.4551/2016

Original

The use of a segmental endoscopic score may improve the prediction of clinical outcomes in acute severe ulcerative colitis

DOI: 10.17235/reed.2016.4470/2016

Letter to the Editor

About human taeniasis and Taenia saginata diagnosis by endoscopy

DOI: 10.17235/reed.2016.4297/2016

Case Report

Intrahepatic clear cell cholangiocarcinoma - An uncommon histologic subtype: case report and literature review

DOI: 10.17235/reed.2017.4239/2016

Digestive Diseases Image

Endoscopic removal of multiple sharp gastro-duodenal foreign bodies

Letter to the Editor

Lupus as a paraneoplastic manifestation of cholangiocarcinoma

DOI: 10.17235/reed.2016.4064/2015

Case Report

Primary non-functioning neuroendocrine tumor of the extrahepatic bile duct

DOI: 10.17235/reed.2016.4071/2015

Letter to the Editor

TIPS treatment in a patient with severe lower gastrointestinal bleeding with a misdiagnosis of cirrhotic portal hypertension

DOI: 10.17235/reed.2015.3794/2015

Case Report

Liver failure posthepatectomy and biliary fistula: multidisciplinar treatment

DOI: 10.17235/reed.2015.3747/2015

Original

Impact of the age of diagnosis on the natural history of ulcerative colitis

DOI: 10.17235/reed.2015.3736/2015

Case Report

Endoscopy as a diagnostic and therapeutic alternative technique of taeniasis

DOI: 10.17235/reed.2015.3585/2014

Citation tools

Gong Y, Wang H, Wang X, Kuang D, Yuan C, Ju J, et all. LncRNA OIP5-AS1 mediated miR-28-5p provides promising support for the diagnosis and prognosis of cholangiocarcinoma. 10632/2024

Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics

This article has received 495 visits.
This article has been downloaded 20 times.

Statistics from Dimensions

Statistics from Plum Analytics

Publication history

Received: 04/07/2024

Accepted: 12/12/2024

Online First: 09/01/2025

Published: 08/05/2025

Article Online First time: 189 days

Article editing time: 308 days

This article hasn't been rated yet.

Reader rating:

Valora este artículo:

Submission and tracking of manuscripts

Instructions to authors

Submission and tracking

Home

Articles

Current issues

Previous issues

Cookie	Purpose	Expiration	Cookie type
ASP.NET_SessionId	Makes it possible to control traffic from the server to multiple users at the same time, identification and access as a user.	Logout / End of project	Session
cookiesDirective	Makes it possible to remember cookie settings.	Logout / End of project	Session
vercookies	Makes it possible to display the notice on the use of cookies.	Logout / End of project	Session

Download to a citation manager

Statistics from Dimensions

Statistics from Plum Analytics

Submission and tracking of manuscripts

Receive the digital monthly newsletter of the REED

In accordance with current legislation, this publication is only for health care professionals.