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Year 2025 / Volume 117 / Number 5
Original

LncRNA OIP5-AS1 mediated miR-28-5p provides promising support for the diagnosis and prognosis of cholangiocarcinoma

256-264

DOI: 10.17235/reed.2024.10632/2024

Yanqing Gong, Huimin Wang, Xiaoming Wang, Deli Kuang, Chunmiao Yuan, Jianhua Ju,

Abstract

Background: long non-coding RNAs (lncRNAs) are a major research focus in a variety of diseases, and lncRNA OIP5-AS1 (OIP5-AS1) was shown to mediate the progression of various tumors. This article discusses how OIP5-AS1 could potentially be used to diagnose and prognosticate cholangiocarcinoma (CHOL). Methods: the ENROCI project evaluated OIP5-AS1 expression in CHOL samples, which was confirmed by RT-qPCR. A bioinformatics database predicted the target gene of OIP5-AS1 in CHOL, which was then confirmed by luciferase activity assays. The CCK-8 and Transwell methods were employed to detect the changes in CHOL cell growth and migration levels after OIP5-AS1 knockdown. ROC and Kaplan-Meier curves were used to examine the diagnostic and prognostic functions of OIP5-AS1. Results: in CHOL tissues and cells, OIP5-AS1 was enhanced compared to the controls. Reducing OIP5-AS1 hampered the regulatory capacity of CHOL cells, which was restored by the miR-28-5p inhibitor. Notably, OIP5-AS1 was observed to sponge and downregulate miR-28-5p, exhibiting high sensitivity and specificity (84.4 % and 81.3 %) in CHOL. G3BP1 was a direct target of miR-28-5p. Decreased OIP5-AS1 level was beneficial for survival (HR = 2.391, p = 0.024). Conclusion: OIP5-AS1 targets and negatively mediates miR-28-5p/G3BP1 axis to promote the activity of CHOL cells, which may be a potential marker for diagnosis and prognosis of CHOL patients.

Lay Summary

Long non-coding RNAs are a major research focus in a variety of diseases, and lncRNA OIP5-AS1 (OIP5-AS1) was shown to mediate the progression of various tumors. This paper discusses how OIP5-AS1 could potentially be used to diagnose and prognosticate cholangiocarcinoma. In our study, OIP5-AS1 expression was upregulated in cholangiocarcinoma tissues and cells, and was related to shorter survival time. OIP5-AS1 targets and negatively mediates miR-28-5p/G3BP1 axis to promote the activity of cholangiocarcinoma cells, which may be a potential marker for diagnosis and prognosis of cholangiocarcinoma patients.

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Endoscopic closure of tracheoesophageal fistula for tuberculosis with an over-the-scope-clip

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Case Report

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DOI: 10.17235/reed.2015.3585/2014

Citation tools

Gong Y, Wang H, Wang X, Kuang D, Yuan C, Ju J, et all. LncRNA OIP5-AS1 mediated miR-28-5p provides promising support for the diagnosis and prognosis of cholangiocarcinoma. 10632/2024

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Publication history

Received: 04/07/2024

Accepted: 12/12/2024

Online First: 09/01/2025

Published: 08/05/2025

Article Online First time: 189 days

Article editing time: 308 days

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