Year 2025 / Volume 117 / Number 5
Letter
Lymphoepithelioma-like cholangiocarcinoma mimicking hepatocellular carcinoma

282-283

DOI: 10.17235/reed.2023.10079/2023

Chuanlin Yu, Yaqiong He,

Abstract
Lymphoepithelioma like cholangiocarcinoma (LELCC) is a rare low-grade malignancy with a favorable prognosis. This sarcoma has a strong association with Epstein-Barr virus (EBV). Most of these have been benign, with some malignant instances noted as well. In our case, this tumor exhibited imaging characteristics of HCC. When patients showed recurrent tonsillitis at an early age, AFP did not change significantly, and there was no previous history of hepatitis B. In such scenario, diagnosis of LELCC should be considered.
New comment
Comments
No comments for this article
References
1.Huang YH, Zhang CZ, Huang QS, et al. Clinicopathologic features, tumor immune microenvironment and genomic landscape of Epstein-Barr virus-associated intrahepatic cholangiocarcinoma. J Hepatol 2021;74(4):838-849. DOI: 10.1016/j.jhep.2020.10.037.
2.Chen M, Chen Y, Fang X, et al. Clinical features and treatment outcome of lymphoepithelioma-like carcinoma from multiple primary sites: a population-based, multicentre, real-world study. BMC Pulm Med 2022;22(1):360. DOI: 10.1186/s12890-022-02097-6.
3.García-Redondo M, Sánchez-Fuentes PA, Ruiz Pardo J, et al. Lymphoepithelioma-like gastric adenocarcinoma. Descriptive case series. Rev Esp Enferm Dig 2023. DOI: 10.17235/reed.2023.9768/2023.
4.Labgaa I, Stueck A, Ward SC. Lymphoepithelioma-Like Carcinoma in Liver. Am J Pathol 2017;187(7):1438-1444. DOI: 10.1016/j.ajpath.2017.02.022.
Related articles

Editorial

Diagnosing hilar cholangiocarcinoma: ERCP with cholangioscopy

DOI: 10.17235/reed.2025.11051/2024

Editorial

Living donor liver transplantation in 2024

DOI: 10.17235/reed.2024.10953/2024

Editorial

Early liver transplantation in severe alcohol-associated hepatitis

DOI: 10.17235/reed.2024.10881/2024

Letter

Malignant melanoma with liver, stomach, and duodenal metastasis

DOI: 10.17235/reed.2024.10851/2024

Editorial

Lights and shadows in the new definition of steatotic liver disease

DOI: 10.17235/reed.2024.10696/2024

Letter

Abernethy syndrome as a cause of liver transplantation

DOI: 10.17235/reed.2024.10561/2024

Letter

Gastric neuroendocrine tumor presenting with carcinoid syndrome

DOI: 10.17235/reed.2024.10364/2024

Letter

IgG4-related disease mimicking a liver abscess

DOI: 10.17235/reed.2024.10265/2024

Letter

Transverse colon volvulus in a young patient with wandering liver

DOI: 10.17235/reed.2024.10245/2023

Letter

Mesalamine induced hepatotoxicity. Is mesalamine safe?

DOI: 10.17235/reed.2024.10131/2023

Letter

Fatal HBV-liver failure after withdrawal of antiviral treatment

DOI: 10.17235/reed.2024.10115/2023

Letter

Pelvic actinomycosis secondary to an intrauterine device

DOI: 10.17235/reed.2023.10077/2023

Letter

Ileal metastasis from phyllodes breast tumor

DOI: 10.17235/reed.2023.9958/2023

Letter

A case of complex hemangioendothelioma of the liver in an infant

DOI: 10.17235/reed.2023.9949/2023

Letter

Gastric schwannoma diagnosing gastric stromal tumor

DOI: 10.17235/reed.2023.9919/2023

Letter

An uncommon cause of intestinal obstruction: Vanek’s tumor

DOI: 10.17235/reed.2023.9914/2023

Digestive Diseases Image

Extremely giant liver hemangioma: a case beyond the norms

DOI: 10.17235/reed.2023.9877/2023

Digestive Diseases Image

Enteroenteric intussusception caused by a small bowel metastatic cutaneous melanoma

DOI: 10.17235/reed.2023.9876/2023

Digestive Diseases Image

Demystify esophageal submucosal tumor: angiomas

DOI: 10.17235/reed.2023.9807/2023

Letter

An unusual cause of liver lesions

DOI: 10.17235/reed.2023.9787/2023

Editorial

Diagnosis and management of Abernethy syndrome

DOI: 10.17235/reed.2023.9781/2023

Letter

Pseudo-submucosal tumor in the colon: seeing is believing

DOI: 10.17235/reed.2023.9773/2023

Letter

Calcifying fibrous tumor and pathological analysis

DOI: 10.17235/reed.2023.9739/2023

Letter

Surgical indication of type I gastric neuroendocrine tumors

DOI: 10.17235/reed.2023.9681/2023

Letter

Mucosal Schwann cell hamartoma: a benign and little-known entity

DOI: 10.17235/reed.2023.9652/2023

Digestive Diseases Image

Endoscopic submucosal dissection of an anorectal Condyloma acuminatum

DOI: 10.17235/reed.2023.9622/2023

Letter

Amyloidosis: a rare cause of severe acute liver failure

DOI: 10.17235/reed.2023.9598/2023

Letter

Icteric syndrome secondary to polycystic liver disease

DOI: 10.17235/reed.2023.9590/2023

Letter

Carcinoid syndrome and somatostatin analogues

DOI: 10.17235/reed.2023.9525/2023

Letter

Liver disorders and celiac disease

DOI: 10.17235/reed.2023.9516/2023

Digestive Diseases Image

Germ cell tumor with duodenal involvement: a rare case of gastrointestinal bleeding

DOI: 10.17235/reed.2022.9327/2022

Letter

Budd-Chiari syndrome in Behçet’s disease

DOI: 10.17235/reed.2022.9267/2022

Letter

A rare endoscopic finding: primary esophageal melanoma

DOI: 10.17235/reed.2022.9244/2022

Letter

Colonic malignancy: always adenocarcinomas?

DOI: 10.17235/reed.2022.9223/2022

Editorial

Drug induced liver injury by immunotherapy

DOI: 10.17235/reed.2022.9179/2022

Letter

GIST is not all that it seems

DOI: 10.17235/reed.2022.8974/2022

Letter

Epithelioid angiomyolipoma of the liver: an incidental diagnosis

DOI: 10.17235/reed.2022.8895/2022

Letter

Intra-abdominal epithelioid angiosarcoma

DOI: 10.17235/reed.2022.8878/2022

Review

Immunotherapy in hepatocellular carcinoma

DOI: 10.17235/reed.2022.8876/2022

Letter

Ectopic ACTH syndrome in a patient with Crohn’s disease

DOI: 10.17235/reed.2022.8825/2022

Letter

Digestive tract MALT lymphoma, an unusual location

DOI: 10.17235/reed.2022.8800/2022

Digestive Diseases Image

Liver abscess due to parvimonas micra

DOI: 10.17235/reed.2022.8751/2022

Letter

Cytomegalovirus colitis seems to be colon cancer. HIV debut

DOI: 10.17235/reed.2022.8699/2022

Digestive Diseases Image

Posterior reversible encephalopathy syndrome (PRES) in post liver transplantation

DOI: 10.17235/reed.2022.8694/2022

Digestive Diseases Image

Ileal neuroendocrine tumor as an uncommon cause of obscure gastrointestinal bleeding

DOI: 10.17235/reed.2022.8641/2022

Letter

Successful endoscopic removal of a giant duodenal bulb mass

DOI: 10.17235/reed.2022.8595/2022

Digestive Diseases Image

Gastric gastrointestinal stromal tumor abscess

DOI: 10.17235/reed.2022.8580/2022

Editorial

Acute pancreatitis: an opportunity for gastroenterology hospitalists?

DOI: 10.17235/reed.2022.8573/2022

Letter

Gastric ulcer with liver penetration

DOI: 10.17235/reed.2022.8528/2021

Letter

Ertapenem neurotoxicity in liver transplantation

DOI: 10.17235/reed.2021.8469/2021

Digestive Diseases Image

Ischemic cholangiopathy following hepatic artery pseudoaneurysm with thrombosis

DOI: 10.17235/reed.2021.8395/2021

Letter

Endoscopic full-thickness resection of a gastric schwannoma

DOI: 10.17235/reed.2021.8385/2021

Letter

Gruber-Frantz tumor: a rare pancreatic neoplasm

DOI: 10.17235/reed.2021.8345/2021

Digestive Diseases Image

Giant cystic hepatocarcinoma in the absence of cirrhosis

DOI: 10.17235/reed.2021.8313/2021

Digestive Diseases Image

Endoscopic resection of a duodenal neuroendocrine tumor

DOI: 10.17235/reed.2021.8232/2021

Letter

Unexpected diagnosis for nodular hepatic lesions

DOI: 10.17235/reed.2021.8230/2021

Digestive Diseases Image

Small bowel occlusion secondary to a giant abdominal solitary fibrous tumor

DOI: 10.17235/reed.2021.8196/2021

Letter

Clip migration after cholecystectomy

DOI: 10.17235/reed.2021.8156/2021

Letter

EBVMCU in a liver-transplant patient

DOI: 10.17235/reed.2021.8064/2021

Review

A review of the diagnosis and management of liver hydatid cyst

DOI: 10.17235/reed.2021.7896/2021

Letter

COVID-19 and the liver: the chicken or the egg dilemma

DOI: 10.17235/reed.2021.7861/2021

Digestive Diseases Image

Percutaneous treatment of a splenorenal shunt with an atrial septal closure device

DOI: 10.17235/reed.2020.7701/2020

Digestive Diseases Image

Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the liver

DOI: 10.17235/reed.2020.7602/2020

Review

Physical frailty in liver transplantation

DOI: 10.17235/reed.2020.7448/2020

Letter

Acute hepatitis due to olmesartan: an uncommon entity

DOI: 10.17235/reed.2020.7236/2020

Letter

Management of hepatic artery aneurysms

DOI: 10.17235/reed.2020.7219/2020

Digestive Diseases Image

Epithelioid hemangioendothelioma: a rare cause of a liver tumor

DOI: 10.17235/reed.2020.7127/2020

Original

Gastric plexiform fibromyxoma, an uncommon mesenchymal tumor

DOI: 10.17235/reed.2020.7048/2020

Review

Pyroptosis in liver disease

DOI: 10.17235/reed.2020.7034/2020

Letter

Giant pancreatic cystic lymphangioma

DOI: 10.17235/reed.2020.7003/2020

Letter

Biopsy for hepatocellular carcinoma: only occasionally

DOI: 10.17235/reed.2020.6935/2020

Digestive Diseases Image

Endoscopic submucosal dissection of colonic anisakiasis

DOI: 10.17235/reed.2020.6748/2019

Original

A new pattern in hepatitis A virus infection in an urban population

DOI: 10.17235/reed.2020.6526/2019

Digestive Diseases Image

A rare cause of extrahepatic biliary tract stricture: a neuroendocrine carcinoma

DOI: 10.17235/reed.2020.6491/2019

Letter

Primary gastric choriocarcinoma

DOI: 10.17235/reed.2020.6478/2019

Case Report

Ectopic hepatocellular carcinoma arising from the peritoneum

DOI: 10.17235/reed.2019.6408/2019

Letter

Hepatic epithelioid angiomyolipoma: contribution of a new case

DOI: 10.17235/reed.2019.6388/2019

Digestive Diseases Image

Concurrent hepatic and renal angiomyolipomas in tuberous sclerosis complex

DOI: 10.17235/reed.2020.6376/2019

Letter

Klatskin-mimicking neuroendocrine tumor

DOI: 10.17235/reed.2019.6382/2019

Review

Psoriasis and fatty liver: a harmful synergy

DOI: 10.17235/reed.2019.6263/2019

Letter

Ruptured hepatic sarcoma as a cause of acute abdomen

DOI: 10.17235/reed.2019.6163/2019

Letter

A giant liver abscess due to Fasciola hepatica infection

DOI: 10.17235/reed.2019.6136/2018

Editorial

Safe surgery for cystic tumors of the pancreas

DOI: 10.17235/reed.2019.6042/2018

Letter

A granular cell tumor: an unusual colon polyp

DOI: 10.17235/reed.2018.5918/2018

Letter

Retroperitoneal schwannoma

DOI: 10.17235/reed.2018.5569/2018

Letter to the Editor

Author´s reply: Cystic pancreatic neuroendocrine tumors. A diagnostic challenge

DOI: 10.17235/reed.2018.5415/2017

Letter

Giant hepatobiliary cystadenoma: clinic-pathological findings

DOI: 10.17235/reed.2018.5414/2017

Letter to the Editor

Post-transplant lymphoproliferative disease after liver transplantation

DOI: 10.17235/reed.2017.5387/2017

Letter to the Editor

EUS-guided ethanol ablation therapy for gastric stromal tumors

DOI: 10.17235/reed.2017.5361/2017

Letter to the Editor

Complicated peribiliary cysts in patient without any prior liver disease

DOI: 10.17235/reed.2017.5350/2017

Digestive Diseases Image

Giant intra-abdominal liposarcoma

DOI: 10.17235/reed.2018.5176/2017

Digestive Diseases Image

Right-colon mucinous adenocarcinoma mimicking a hydatid cyst

DOI: 10.17235/reed.2017.5041/2017

Letter to the Editor

A case of a mixed adenoneuroendocrine tumor of the colon

DOI: 10.17235/reed.2017.5008/2017

Letter to the Editor

Neuroendocrine tumors of the pancreas: keys issues in dealing with heterogeneity

DOI: 10.17235/reed.2017.4997/2017

Letter to the Editor

Pancreatic neuroendocrine tumors. Prognostic factors

DOI: 10.17235/reed.2017.5109/2017

Letter to the Editor

Chronic diarrhea, weight loss and heart failure. Features of the same disease?

DOI: 10.17235/reed.2017.4874/2017

Letter to the Editor

Pancreatic neuroendocrine tumors

DOI: 10.17235/reed.2017.4725/2016

Editorial

Pancreas neuroendocrine tumors - not so rare or benign

DOI: 10.17235/reed.2016.4672/2016

Letter to the Editor

Endoscopic full-thickness resection for a gastric angioleiomyoma

DOI: 10.17235/reed.2017.4568/2016

Digestive Diseases Image

Debut of an unusual liver cirrhosis

Letter to the Editor

Ball valve syndrome caused by a giant gastric Vanek’s tumor

DOI: 10.17235/reed.2017.4526/2016

Letter to the Editor

Liver metastasis from colorectal cancer 12 years after liver transplantation

DOI: 10.17235/reed.2017.4507/2016

Letter to the Editor

Unusual presentation of obstructive jaundice

DOI: 10.17235/reed.2017.4501/2016

Case Report

The clinical extremes of autoimmune cholangitis

DOI: 10.17235/reed.2017.4167/2015

Letter to the Editor

Transanal submucosal endoscopic resection (TASER) by TEO system®

DOI: 10.17235/reed.2016.4154/2015

Letter to the Editor

Gastric neuroendocrine tumor presenting with gastrointestinal bleeding

DOI: 10.17235/reed.2015.3998/2015

Letter to the Editor

Surgical management of appendiceal adenocarcinoid. Case report and literature review

DOI: 10.17235/reed.2016.4049/2015

Letter to the Editor

Endoscopic submucosal dissection for a gastric fibrolipoma

DOI: 10.17235/reed.2015.3982/2015

Case Report

Glycogenic hepatopathy in young adults: a case series

DOI: 10.17235/reed.2016.3934/2015

Review

Endoscopic ampullectomy: a technical review

DOI: 10.17235/reed.2016.3867/2015

Case Report

Pelvic inflammatory myofibroblastic tumor mimicking a rectal cancer

DOI: 10.17235/reed.2015.3777/2015

Case Report

Mesenteric tumor due to chronic anisakiasis

DOI: 10.17235/reed.2015.3687/2015

Letter to the Editor

Duodenal involvement by seminomatous tumors

DOI: 10.17235/reed.2015.3646/2014

Letter to the Editor

Synchronic gastric and pancreatic ductal adenocarcinoma. A case report

DOI: 10.17235/reed.2015.3720/2014

Letter to the Editor

Severe acute liver failure and thyrotoxicosis: an unusual association

DOI: 10.17235/reed.2015.3607/2014

Letter to the Editor

Leiomyosarcoma of the ascending colon: a rare tumor with poor prognosis

DOI: 10.17235/reed.2015.3606/2014

Letter to the Editor

PITAVASTATIN: OTHER STATIN TO BE USED AND MONITORED

DOI: 10.17235/reed.2015.3565/2014

Letter to the Editor

Liver abscess by Eikenella Corrodens

DOI: 10.17235/reed.2015.3613/2014

Letter to the Editor

Leiomyoma of the round ligament of the liver: Report of one case

DOI: 10.17235/reed.2015.3725/2014

Citation tools
Yu C, He Y. Lymphoepithelioma-like cholangiocarcinoma mimicking hepatocellular carcinoma. 10079/2023


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 26 visits.
This article has been downloaded 3 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 08/11/2023

Accepted: 15/11/2023

Online First: 20/11/2023

Published: 08/05/2025

Article Online First time: 12 days

Article editing time: 547 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2025 y Creative Commons. The Spanish Journal of Gastroenterology