Año 2022 / Volumen 114 / Número 10
Original
Metabolic syndrome before liver transplantation: does it have an impact on post liver transplantation outcome?

586-591

DOI: 10.17235/reed.2022.8384/2021

Julia Herreras López, Lorena Puchades, Tommaso Di Maira, Antonio José Cañada, Javier Maupoey, Rafael López-Andújar, Martín Prieto Castillo, Marina Berenguer Haym, Victoria Aguilera,

Resumen
Introduction: Metabolic syndrome (MS) and cardiovascular risk factors are common in liver transplant (LT) candidates and recipients. Cardiovascular events and de novo tumors are increasingly common causes of mortality in liver transplant recipients. The aim of this study were (i) assess the prevalence of MS in LT recipients and its growth over the years and (ii) determine if the presence of MS pre-LT is associated with a higher risk of post-LT cardiovascular events (CVE), de novo tumors or early and late survival. Patients and methods: A retrospective study was performed that included LT recipients from January 2012 to December 2017. Baseline features (MS before LT and at 1year post-LT) and outcomes (CVE, de novo tumors and survival) were recorded. Results: 483 recipients were included, MS was present in 20% of pre-LT with an increasing prevalence over time, from 16% in 2012 to 34% in 2017 (p=0.025). One-year post-LT, an additional 12% had developed de novo MS. At a median of 56-months follow-up, 13% developed a CVE and 9% a de novo tumor. One and 5-yr survival rates were 91% and 83% in those with pre-LT MS and 93% and 85% in those without (p=0.94).The presence of MS before LT was independently associated with a higher risk of post-LT CVE (HR: 2.66 IC (95%): 1.6-4.4 p< 0.001), but not with de novo tumors (p=0.94) nor early and late survival (p=0.58 and p=0.87). Conclusion: Pre-LT MS is increasing among LT candidates and is associated with a higher risk of post-LT morbidity CVE yet without affecting mortality.  
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Instrucciones para citar
Herreras López J, Puchades L, Di Maira T, Cañada A, Maupoey J, López-Andújar R, et all. Metabolic syndrome before liver transplantation: does it have an impact on post liver transplantation outcome?. 8384/2021


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Ficha Técnica

Recibido: 10/10/2021

Aceptado: 18/01/2022

Prepublicado: 20/01/2022

Publicado: 07/10/2022

Tiempo de revisión del artículo: 91 días

Tiempo de prepublicación: 102 días

Tiempo de edición del artículo: 362 días


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