Year 2023 / Volume 115 / Number 12
Letter
Plasma levels of intestinal fatty-acid binding protein (I-FABP), abdominal distension and hydrogen concentration after lactitol small intestinal bacterial overgrowth (SIBO) test

727-728

DOI: 10.17235/reed.2023.9578/2023

Carlos Maroto, Aida Fiz-López, Raquel Pastor, David Bernardo, José Antonio Garrote, Eduardo Arranz, Luis Fernández Salazar,

Abstract
Breath tests with glucose, lactulose or lactitol are useful for diagnosis of small intestinal bacterial overgrowth (SIBO). Nevertheless, they have suboptimal sensitivity and specificity and, indeed, are positive in a considerable number of patients with irritable bowel syndrome (IBS). The complexity in the management of patients with functional intestinal disorders and the availability of these tests are leading to frequent diagnoses of SIBO. Intestinal Fatty-Acid Binding protein (I-FABP) is a protein present in the cytosol of intestinal epithelial cells. Its plasmatic levels have been related to different enteropathies and, therefore, could be a marker of early intestinal damage with unconfirmed clinical utility. Hence, we have studied the plasmatic I-FABP level of patients who are requested a lactitol test to confirm SIBO and related it to clinical and laboratory characteristics and SIBO test results.
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References
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Citation tools
Maroto C, Fiz-López A, Pastor R, Bernardo D, Garrote J, Arranz E, et all. Plasma levels of intestinal fatty-acid binding protein (I-FABP), abdominal distension and hydrogen concentration after lactitol small intestinal bacterial overgrowth (SIBO) test. 9578/2023


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Publication history

Received: 06/03/2023

Accepted: 11/03/2023

Online First: 17/03/2023

Published: 12/12/2023

Article Online First time: 11 days

Article editing time: 281 days


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