Year 2023 / Volume 115 / Number 9
Review
Diagnostic value of circulating microRNAs for esophageal cancer: a meta-analysis based on Asian data

504-514

DOI: 10.17235/reed.2022.8348/2021

Wen-Ting Zhang, Yan-Jun Wang, Guo-Xun Zhang, Ya-Hui Zhang, Shuai-Shuai Gao,

Abstract
Background and objective: esophageal cancer (EC) is one of the most common gastrointestinal malignant diseases. We conducted a comprehensive meta-analysis to explore the clinical applicability of circulating microRNA for the diagnosis of EC. Methods: as of September 10, 2021, a comprehensive literature search was conducted on PubMed, Embase, Web of Science, Cochrane Library, Wanfang Database, and China National Knowledge Infrastructure (CNKI) to identify eligible studies. The sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were pooled to evaluate the test performance. The potential sources of heterogeneity were analyzed by subgroup analysis. Deeks' funnel plot was used to assess publication bias. Results: 85 studies from 50 articles were included in the current meta-analysis. The overall pooled sensitivity was 0.82 (95 % CI, 0.79-0.84), specificity was 0.84 (95 % CI, 0.81-0.86), PLR was 4.9 (95 % CI, 4.2-5.9), NLR was 0.22 (95 % CI, 0.19-0.25), DOR was 22 (95 % CI, 17-29) and AUC was 0.89 (95 % CI, 0.86-0.92), respectively. Subgroup analysis suggested that miRNA clusters with a large sample size showed better diagnostic accuracy. Publication bias was not found. Conclusions: circulating miRNAs can be used as a potential non-invasive biomarker for the diagnosis of EC in Asian populations.
Share Button
New comment
Comments
No comments for this article
References
1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians 2018;68:394-424.
2. Wong MCS, Hamilton W, Whiteman DC, et al. Global Incidence and mortality of oesophageal cancer and their correlation with socioeconomic indicators temporal patterns and trends in 41 countries. Scientific Reports 2018;8:4522.
3. Lin Z, Chen Y, Lin Y, et al. Potential miRNA biomarkers for the diagnosis and prognosis of esophageal cancer detected by a novel absolute quantitative RT-qPCR method. Scientific Reports 2020;10:20065.
4. Yazbeck R, Jaenisch SE, Watson DI. From blood to breath: New horizons for esophageal cancer biomarkers. World Journal of Gastroenterology 2016;22:10077-83.
5. Chu LY, Peng YH, Weng XF, et al. Blood-based biomarkers for early detection of esophageal squamous cell carcinoma. World journal of gastroenterology 2020;26:1708-25.
6. Cui M, Wang H, Yao X, et al. Circulating MicroRNAs in Cancer: Potential and Challenge. Frontiers in genetics 2019;10:626.
7. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ (Clinical research ed) 2009;339:b2535.
8. Whiting PF, Rutjes AW, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Annals of internal medicine 2011;155:529-36.
9. Zhang C, Wang C, Chen X, et al. Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma. Clinical chemistry 2010;56:1871-9.
10. Zhang T, Wang Q, Zhao D, et al. The oncogenetic role of microRNA-31 as a potential biomarker in oesophageal squamous cell carcinoma. Clinical science (London, England : 1979) 2011;121:437-47.
11. Zhang Y, Li Y, Wang C, et al. Sequencing and identification of mircORNAs from a genome-wide expression profile in serum of esophageal squamous cell carcinoma. J Clin Lab Sci. 2012;30(9):641-44.
12. Wang B, Zhang Q. The expression and clinical significance of circulating microRNA-21 in serum of five solid tumors. Journal of cancer research and clinical oncology 2012;138:1659-66.
13. Xie Z, Chen G, Huang J, Li Z. The diagnostic significance of plasma miR-10b for esophageal cancer. Guangdong Medical Journal 2013; 16: 2465–8.
14. Hirajima S, Komatsu S, Ichikawa D, et al. Clinical impact of circulating miR-18a in plasma of patients with oesophageal squamous cell carcinoma. British journal of cancer 2013;108:1822-9.
15. Takeshita N, Hoshino I, Mori M, et al. Serum microRNA expression profile: miR-1246 as a novel diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma. British journal of cancer 2013;108:644-52.
16. Zhang T, Zhao D, Wang Q, et al. MicroRNA-1322 regulates ECRG2 allele specifically and acts as a potential biomarker in patients with esophageal squamous cell carcinoma. Molecular carcinogenesis 2013;52:581-90.
17. Komatsu S, Ichikawa D, Hirajima S, et al. Plasma microRNA profiles: identification of miR-25 as a novel diagnostic and monitoring biomarker in oesophageal squamous cell carcinoma. British journal of cancer 2014;111:1614-24.
18. Ye M, Ye P, Zhang W, et al. Diagnostic values of salivary versus and plasma microRNA-21 for early esophageal cancer. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2014;34:885-9.
19. Wu C, Wang C, Guan X, et al. Diagnostic and prognostic implications of a serum miRNA panel in oesophageal squamous cell carcinoma. PloS one 2014;9:e92292.
20. Dong W, Li B, Wang Z, et al. Clinical significance of microRNA-24 expression in esophageal squamous cell carcinoma. Neoplasma 2015;62:250-8.
21. Li W, Yan CL, Tan XG. Diagnostic value of application of salivary and plasma microRNA-21 in early esophageal cancer. Chongqing Med; 2015:1894–6.
22. He FC, Meng WW, Qu YH, et al. Expression of circulating microRNA-20a and let-7a in esophageal squamous cell carcinoma. World journal of gastroenterology 2015;21:4660-5.
23. Hui B, Chen X, Hui L, et al. Serum miRNA expression in patients with esophageal squamous cell carcinoma. Oncology letters 2015;10:3008-12.
24. Jiang Z, Song Q, Yang S, et al. Serum microRNA-218 is a potential biomarker for esophageal cancer. Cancer biomarkers : section A of Disease markers 2015;15:381-9.
25. Li BX, Shi ZL, Yu Q, et al. Dynamic monitoring of MIR-21 in peripheral blood before and after radiotherapy in patients with esophageal carcinoma and its clinical implication. Tumor 2015;35:550-5.
26. Xu H, Yao Y, Meng F, et al. Predictive Value of Serum miR-10b, miR-29c, and miR-205 as Promising Biomarkers in Esophageal Squamous Cell Carcinoma Screening. Medicine 2015;94:e1558.
27. Shi XY, Wang Q, Jiang XY, Xu L, Wu J, Zhang C. et al. Value of real-time fluorescent quantitative polymerase chain reaction in detecting expression of miR-100 in patients with esophageal cancer. Int J Lab Med. 2016;37:738–9.
28. Sun L, Dong S, Dong C, et al. Predictive value of plasma miRNA-718 for esophageal squamous cell carcinoma. Cancer biomarkers 2016;16:265-73.
29. Dong S, Yin H, Dong C, et al. Predictive Value of Plasma MicroRNA-216a/b in the Diagnosis of Esophageal Squamous Cell Carcinoma. Disease markers 2016;2016:1857067.
30. Guan S, Wang C, Chen X, et al. MiR-613: a novel diagnostic and prognostic biomarker for patients with esophageal squamous cell carcinoma. Tumour biology 2016;37:4383-91.
31. Wang C, Guan S, Liu F, et al. Prognostic and diagnostic potential of miR-146a in oesophageal squamous cell carcinoma. British journal of cancer 2016;114:290-7.
32. Li SP, Su HX, Zhao D, et al. Plasma miRNA-506 as a Prognostic Biomarker for Esophageal Squamous Cell Carcinoma. Medical science monitor : international medical journal of experimental and clinical research 2016;22:2195-201.
33. Wang C, Li Q, Liu F, et al. Serum miR-1297: a promising diagnostic biomarker in esophageal squamous cell carcinoma. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2016;21:517-22.
34. Zheng S, Zhang X, Wang X, et al. Downregulation of miR-138 predicts poor prognosis in patients with esophageal squamous cell carcinoma. Cancer biomarkers 2017;20:49-54.
35. Li J, Li M, Gao F, et al. Serum microRNA-15a level acts as a potential diagnostic and prognostic biomarker for human esophageal squamous cell carcinoma. Cancer Biomarkers 2017;18:11-7.
36. Bai Y, Lin H, Fang Z, et al. Plasma microRNA-19a as a potential biomarker for esophageal squamous cell carcinoma diagnosis and prognosis. Biomarkers in medicine 2017;11:431-41.
37. Cui Y, Xue Y, Dong S, et al. Plasma microRNA-9 as a diagnostic and prognostic biomarker in patients with esophageal squamous cell carcinoma. The Journal of international medical research 2017;45:1310-7.
38. Xiao X, Zhang X, Qin G. Clinical research of detecing plama miRNA-21 and miRNA-143 for identifying early esophageal cancer and benign esophageal disease. J Mod Lab Med. 2017; 32(4): 72-5.
39. Qin J, Tao J, Li Y, Chang W, Wang L, Zhao X, Wang L. Predictive value of serum miR-25, miR-223, and miR-373 as promising biomarkers in esophageal squamous cell carcinoma. Journal of Henan Normal University( Natural Science Edition) 2017; 45(1): 65-70.
40. Yang Y, Du Y, Zhang C, Wei S, Li Q. The expression level of microRNA-451 and the role of curative effect evoluation in serum of patients with esophageal squamous cell carcinoma. Journal of Xinjiang Medical University. 2017; 40(6):779-82.
41. Chen J, Chen M. (Serum levels of miRNA-183 in patients with esophageal squamous cell carcinoma and its diagnostic value). Journal of Central South University Medical sciences 2018;43:1048-53.
42. Wang K, Chen D, Meng Y, et al. Clinical evaluation of 4 types of microRNA in serum as biomarkers of esophageal squamous cell carcinoma. Oncology letters 2018;16:1196-204.
43. Zhang L, Dong B, Ren P, et al. Circulating plasma microRNAs in the detection of esophageal squamous cell carcinoma. Oncology letters 2018;16:3303-18.
44. Xu LJ, Duan Y, Yin HQ, Song, HR. Expression and significance of serum miRNA-143 in human esophageal squamous cell carcinoma. Chin J Health Lab Tec. 2019; 29(8): 996-9.
45. Sun H, Wang L, Zhao Q, et al. Diagnostic and prognostic value of serum miRNA-1290 in human esophageal squamous cell carcinoma. Cancer biomarkers 2019;25:381-7.
46. Bai Y, Liu Y, Fan X. The value of serum microRNA-1,LASPl,TAGLN2 and LGALS3BP in the diagnosis of esophageal cancer. Chin J of 0ncol Prev and Treat. 2019; 11(4):332-6.
47. Hoshino I, Ishige F, Iwatate Y, et al. Usefulness of serum miR-1246/miR-106b ratio in patients with esophageal squamous cell carcinoma. Oncology letters 2020;20:350.
48. Wu YB, Li YY, Chen HZ. Expression levels and clinical significance of peripheral blood microRNA-15b and microRNA-34c in patients with early esophageal cancer. Guangxi Medical Journal. 2020; 42(10):1228-32.
Related articles

Digestive Diseases Image

A case of esophageal histoplasmosis mimicking carcinoma on endoscopy

DOI: 10.17235/reed.2023.9167/2022

Review

New non-invasive biomarkers for colorectal cancer screening

DOI: 10.17235/reed.2020.7233/2020

Citation tools
Zhang W, Wang Y, Zhang G, Zhang Y, Gao S. Diagnostic value of circulating microRNAs for esophageal cancer: a meta-analysis based on Asian data. 8348/2021


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1012 visits.
This article has been downloaded 56 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 19/09/2021

Accepted: 16/01/2022

Online First: 18/01/2022

Published: 06/09/2023

Article revision time: 117 days

Article Online First time: 121 days

Article editing time: 717 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology