Year 2025 / Volume 117 / Number 11
Letter
Rectal cancer with solitary hepatic metastasis and Lambert-Eaton myasthenic syndrome

678-679

DOI: 10.17235/reed.2024.10682/2024

Xiaorong Chen, Wenyuan Xie, Xiang Zhang, Jie Zhang, Yujun Zhu,

Abstract
Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune neuromuscular disease mediated by antibodies to voltage-gated calcium channels (VGCCs) at the neuromuscular junction. LEMS often presents as a paraneoplastic disease. Between 40% to 62% of patients diagnosed with LEMS are confirmed to have small cell lung cancer (SCLC). There are few concerned reports on Gastrointestinal carcinomas. This article reports the treatment process of a young woman with rectal cancer and liver metastasis who associated with LEMS to summarize relevant clinical experience and reduce the rate of clinical misdiagnosis.
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References
Vincent A, Lang B, Newsom-Davis J. Autoimmunity to the voltage-gated calcium channel underlies the Lambert-Eaton myasthenic syndrome, a paraneoplastic disorder. Trends Neurosci. 1989;12(12):496-502.
Wiendl H, Abicht A, Chan A, et al. Guideline for the management of myasthenic syndromes. Therapeutic Advances in Neurological Disorders. 2023;16.
Titulaer MJ, Wirtz PW, Kuks JB, et al. The Lambert-Eaton myasthenic syndrome 1988-2008: a clinical picture in 97 patients. J Neuroimmunol. 2008;201-202:153-158.
Briggs SE, Gozzard P, Talbot DC. The association between Lambert-Eaton myasthenic syndrome and small cell lung carcinoma. Immunotargets Ther. 2013;2:31-37. Published 2013 May 21.
Maddison P, Gozzard P, Grainge MJ, Lang B. Long-term survival in paraneoplastic Lambert-Eaton myasthenic syndrome. Neurology. 2017;88(14):1334-1339.
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Chen X, Xie W, Zhang X, Zhang J, Zhu Y. Rectal cancer with solitary hepatic metastasis and Lambert-Eaton myasthenic syndrome. 10682/2024


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Publication history

Received: 25/07/2024

Accepted: 31/07/2024

Online First: 05/09/2024

Published: 11/11/2025

Article Online First time: 42 days

Article editing time: 474 days


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