Year 2018 / Volume 110 / Number 9
Original
Prevalence and progression of chronic kidney disease after liver transplant: a prospective, real-life, observational, two-year multicenter study

538-543

DOI: 10.17235/reed.2018.5431/2017

José Ignacio Herrero, Valentín Cuervas-Mons, Miguel Ángel Gómez-Bravo, Joan Fabregat, Alejandra Otero, Itxarone Bilbao, María Magdalena Salcedo, María Luisa González-Diéguez, Jose Ramón Fernández, María Trinidad Serrano, Miguel Jiménez, Juan Miguel Rodrigo, Isidoro Narváez, Gloria Sánchez,

Abstract
Introduction: chronic kidney disease is a frequent complication after liver transplantation. The use of calcineurin inhibitors is one of the causes of this complication. Current immunsuppression regimens that reduce the use of calcineurin inhibitors may be associated with an improved preservation of renal function. Objective: the study aimed to assess the evolution of renal function after liver transplantation in the current routine clinical practice. Methods: an observational, prospective, multicenter study in adult liver transplant recipients was performed. Two hundred and thirty patients with a good renal function before transplantation were assessed six months post-transplantation (baseline) and every six months until month 30. Results: at baseline, 32% of the patients had a reduction in the glomerular filtration rate below < 60 ml/min/1.73 m2. The mean glomerular filtration rate increased from 72.3 to 75.6 ml/min/1.73 m2 at baseline and month 30 respectively (p < 0.01). The mean serum creatinine levels (mg/dl) decreased from 1.13 to 1.09 (p < 0.01). The percentage of patients with stage 3 chronic kidney disease decreased from 31.7% to 26.4%, whereas the percentage of patients with stage 4 remained unchanged (0.4% at baseline and 0.5% at month 30). No patients progressed to end-stage kidney disease that required dialysis or renal transplantation. Conclusion: in the routine clinical practice, a moderate deterioration of renal function is frequent after liver transplantation. However, advanced chronic kidney disease is infrequent in patients with a good pre-transplant renal function.
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Herrero J, Cuervas-Mons V, Gómez-Bravo M, Fabregat J, Otero A, Bilbao I, et all. Prevalence and progression of chronic kidney disease after liver transplant: a prospective, real-life, observational, two-year multicenter study. 5431/2017


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Publication history

Received: 19/12/2017

Accepted: 15/04/2018

Online First: 12/06/2018

Published: 31/08/2018

Article revision time: 114 days

Article Online First time: 175 days

Article editing time: 255 days


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