Year 2018 / Volume 110 / Number 2
Letter to the Editor
Post-transplant lymphoproliferative disease after liver transplantation

131-132

DOI: 10.17235/reed.2017.5387/2017

José Ignacio Herrero, Carlos Panizo,

Abstract
We have read the article “Post-transplant lymphoproliferative disease in liver transplant recipients” with great interest. This article reports a series of liver transplant recipients with post-transplant lymphoproliferative disease (PTLD). The effect on patient survival and the potential benefit of rituximab-based therapy are highlighted. Rituximab is a chimeric antibody against the CD20 surface marker. This marker is found in most PTLD of a B cell origin. A recent study from our center also highlighted the role of rituximab in PTLD therapy (3). The overall response rate of patients treated with rituximab was 66% in both series. In our series, this included heart, kidney and liver transplant recipients. Rituximab-based therapy was also associated with an increased overall survival. Rituximab should be considered as part of the first-line therapy in patients with PTLD when CD20 expression is present.
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References
Rubio-Manzanares Dorado M, Alamo Martinez JM, Bernal Bellido C, et al. Síndrome linfoproliferativo en el trasplante hepatico. Rev Esp Enferm Dig 2017; 109: 406-413.
Maloney DG. Anti-CD20 antibody therapy for B-cell lymphomas. N Engl J Med 2012;366:2008-2016.
Martinez-Calle N, Alfonso A, Rifon J, et al. First-line use of rituximab correlates with increased overall survival in late post-transplant lymphoproliferative disorders: retrospective, single-center study. Eur J Hematol 2016;98:38-43.
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Herrero J, Panizo C. Post-transplant lymphoproliferative disease after liver transplantation. 5387/2017


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Publication history

Received: 20/11/2017

Accepted: 28/11/2017

Online First: 09/01/2018

Published: 31/01/2018

Article Online First time: 50 days

Article editing time: 72 days


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