Año 2023 / Volumen 115 / Número 5
Original
Relationship between DHX15 expression and survival in colorectal cancer

234-240

DOI: 10.17235/reed.2022.8838/2022

Leqi Fan, Xiangyu Guo, Jiyi Zhang, Yuji Wang, Jinhui Wang, Ye Li,

Resumen
Objective: to explore the relationship between the expression of DEAH-box RNA helicase 15 (DHX15) in colorectal cancer (CRC), its clinical pathological features and survival. Method: DHX15 expression data with clinical pathological features from the Cancer Gene Atlas (TCGA) and the Clinical Proteomic Tumor Analysis Consortium (CPTAC) were statistically analyzed for the association between DHX15 expression and overall survival in CRC. The expression of DHX15 was performed by immunohistochemical staining (IHC) using tumor and the adjacent normal tissue, mounted in tissue microarrays. The significance of DHX15 expression to predict survival and prognosis of CRC were analyzed using the Kaplan-Meier method, univariate and multivariate Cox regression analysis. Results: low expression of DHX15 mRNA and DHX15 protein in CRC were both negative factors for survival. Overall survival of patients with low-expression of DHX15 was significantly lower (χ2 = 8.452, p = 0.004) by Kaplan-Meier evaluation. Low expression of DHX15 in CRC tissues correlated with distal lymph node metastasis (χ² = 7.120, p = 0.008), TNM stage (χ² = 3.935, p = 0.047) and disease recurrence (χ² = 9.524, p = 0.002) in CRC. Low expression of DHX15 (HR = 4.012, 95 % CI: 1.462-11.013, p = 0.007), late TNM stage (HR = 0.067, 95 % CI: 0.029-0.156, p < 0.001) and recurrence (HR = 0.008, 95 % CI: 0.002-0.034, p < 0.001) were risk factors related to the prognosis of CRC patients by univariate Cox regression analysis. Conclusion: our findings reveal a key role for DHX15 in the progress of CRC metastasis and recurrence. DHX15 may be a potential biomarker for CRC targeted therapy.
Resumen coloquial
We explored the relationship between the expression of DEAH-box RNA helicase 15 (DHX15) and survival prognosis in colorectal cancer (CRC). Clinical pathological features, survival and the expression of DHX15 of CRC samples were obtained from the Cancer Gene Atlas (TCGA) and the Clinical Proteomic Tumor Analysis Consortium (CPTAC) databases, and subjected to statistical analysis. Furthermore, the expression of DHX15 in both tumor and the adjacent normal tissue of CRC patients was performed by immunohistochemical staining (IHC) mounted in tissue microarrays. As the result, low expression of DHX15 mRNA and DHX15 protein in CRC samples were both poor prognostic factors for CRC survival, metastasis and recurrence.
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Bibliografía
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Instrucciones para citar
Fan L, Guo X, Zhang J, Wang Y, Wang J, Li Y, et all. Relationship between DHX15 expression and survival in colorectal cancer. 8838/2022


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Ficha Técnica

Recibido: 05/04/2022

Aceptado: 19/09/2022

Prepublicado: 30/09/2022

Publicado: 05/05/2023

Tiempo de revisión del artículo: 136 días

Tiempo de prepublicación: 178 días

Tiempo de edición del artículo: 395 días


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