Year 2019 / Volume 111 / Number 11
Special Article
Elimination of hepatitis C. Positioning document of the Spanish Association for the Study of the Liver (AEEH)

862-873

DOI: 10.17235/reed.2019.6700/2019

Javier Crespo, Albillos Albillos, María Buti, José Luis Calleja, Javier García Samaniego, Manuel Hernández Guerra, Trinidad Serrano, Juan Turnes, Enrique Acín, Juan Berenguer, Marina Berenguer, Joan Colom, Inmaculada Fernández, Conrado Fernández Rodríguez, Xavier Forns, Federico García, Rafael Grandados, Jeffrey Lazarus, José María Molero, Esther Molina, Fernando Pérez Escanilla, Juan A. Pineda, Manuel Rodríguez, Manuel Romero, Carlos Roncero, Pablo Saiz de la Hoya, Gloria Sánchez Antolín,

Abstract
The Spanish Association for the Study of the Liver (AEEH) is convinced that the elimination of hepatitis C virus (HCV) in Spain is possible as long as we are able to use the resources and tools necessary for it. This document reflects the position of the AEEH regarding the elimination of HCV, establishing a wide range of recommendations that can be grouped into five categories: 1) Screening of HCV according to age, of the existence of classic acquisition risk factors of infection, active search of previously diagnosed patients and development of microelimination strategies in vulnerable populations; 2) Simplification of HCV diagnosis (one-step diagnosis and diagnosis at the point of patient care); 3) Simplification of patient treatment and improvement of care circuits; 4) Health policy measures, and, finally, 5) Establishment of HCV elimination indicators.
New comment
Comments
No comments for this article
References
1. Cooke GS, Andrieux-Meyer I, Applegate TL, Atun R, Burry JR, Cheinquer H, et al. Accelerating the elimination of viral hepatitis: A Lancet Gastroenterology & Hepatology Commission. Lancet Gastroenterol Hepatol 2019;4:135-84. Fe de erratas: Lancet Gastroenterol Hepatol 2019;4(5):e4.
DOI: 10.1016/S2468-1253(19)30099-8
2. Chen Q, Ayer T, Bethea E, Kanwal F, Wang X, Roberts M, et al. Changes in hepatitis C burden and treatment trends in Europe during the era of direct-acting antivirals: A modelling study. BMJ Open 2019;9:e026726.
DOI: 10.1136/bmjopen-2018-026726
3. Aguinaga A, Díaz-González J, Pérez-García A, Barrado L, Martínez-Baz I, Casado I, et al. The prevalence of diagnosed and undiagnosed hepatitis C virus infection in Navarra, Spain, 2014-2016. Enferm Infecc Microbiol Clin 2018;36:325-31.
DOI: 10.1016/j.eimc.2016.12.008
4. Cuadrado A, Llerena S, Escudero MD, Gómez M, Estébanez A, Puchades L, et al. Diseño y coste-efectividad de una política de eliminación del VHC basada en un estudio epidemiológico actualizado (cohorte Ethon). Gastroenterol Hepatol 2017. Congreso anual de la Asociación Española para el Estudio del Hígado (AEEH).
5. Rodríguez-Tajes SDY, Collazos C, Frías MC, Vidal Benede MJ, Jané M, Domínguez A, et al. Estudio de prevalencia de infección por los virus hepatitis B y C en Catalun˜a. Gastroenterol Hepatol 2017. Congreso anual de la Asociación Española para el Estudio del Hígado (AEEH).
6. Fernández-Bermejo M, Íñiguez R, Mata P, Ferreira H, Gómez B, Mateos J, et al. Estudio de prevalencia de serología de hepatitis C en un área de salud con población rural. Gastrenterol Hepatol 2017. Congreso de la Asociación Española para el Estudio del Hígado (AEEH).
7. Informe del Ministerio de Sanidad de Seroprevalencia del VHC en España. Disponible en: http://www.mscbs. gob.es/ciudadanos/enfLesiones/enfTransmisibles/sida/docs/INFORME INFECCION VHC ESPANA2019.pdf.
8. Juanbeltz R, Pérez-García A, Aguinaga A, Martínez-Baz I, Casado I, Burgui C, et al. Progress in the elimination of hepatitis C virus infection: A population-based cohort study in Spain. PLoS One 2018;13:e0208554.
DOI: 10.1371/journal.pone.0208554
9. Gómez-Escolar Viejo L, García Herola A, Sáez Lloret I, Sánchez Ruano F, Clemente Paulino I, Quílez Ivorra C, et al. Screening of hepatitis C virus infection in adult general population in Spain. Eur J Gastroenterol Hepatol 2018;30:1077-81, http://dx.doi.org/10.1097/MEG.0000000000001190.
10. Berenguer M, de la Rosa Rodríguez G, Domínguez Gil B. Significant impact of new oral therapies against HCV on the waiting list for liver transplantation in Spain. J Hepatol 2018;69:966-8.
DOI: 10.1016/j.jhep.2018.06.011
11. OMS. Estrategia mundial del sector de la salud contra las hepatitis víricas 2016-2021. Hacia el fin de las hepatitis víricas. Junio de 2016.
12. Secretaría General de Sanidad y Consumo. Ministerio de Sanidad, Consumo y Bienestar Social. Plan Estratégico para el Abordaje de la Hepatitis C en el Sistema Nacional de Salud (PEAHC). Disponible en: https://www.mscbs.gob. es/ciudadanos/enfLesiones/enfTransmisibles/hepatitisC/PlanEstrategicoHEPATITISC/home.htm.
13. Mar J, Ibarrondo O, Martínez-Baz I, Juanbeltz R, San MR, Casado I, et al. Economic evaluation of a population strategy for the treatment of chronic hepatitis C with direct-acting antivirals. Rev Esp Enferm Dig 2018;110:621-8.
DOI: 10.17235/reed.2018.5605/2018
14. Turnes J, Domínguez-Hernández R, Casado MA. Value and innovation of direct-acting antivirals: Long-term health outcomes of the strategic plan for the management of hepatitis C in Spain. Rev Esp Enferm Dig 2017;109:809-17.
DOI: 10.17235/reed.2017.5063/2017
15. Oliva-Moreno J, Pena-Longobardo LM, Alonso S, Fernández-Bolaños A, Gutiérrez ML, Hidalgo-Vega A, et al. Labour productivity losses caused by premature death associated with hepatitis C in Spain. Eur J Gastroenterol Hepatol 2015;27:631-7.
DOI: 10.1097/MEG.0000000000000336
16. Puig-Junoy J, Pascual-Argente N, Puig-Codina L, Planellas L, Solozabal M. Cost-utility analysis of second-generation directacting antivirals for hepatitis C: A systematic review. Expert Rev Gastroenterol Hepatol 2018;12:1251-63.
DOI: 10.1080/17474124.2018.1540929
17. Buti M, Domínguez-Hernández R, Casado MA, Sabater E, Esteban R. Healthcare value of implementing hepatitis C screening in the adult general population in Spain. PLoS One 2018;13:e0208036.
DOI: 10.1371/journal.pone.0208036
18. Gómez-Escolar VL, García HA, Sáez L, Sánchez IRF, Clemente PI, Quilez IC, et al. Screening of hepatitis C virus infection in adult general population in Spain. Eur J Gastroenterol Hepatol 2018;30:1077-81.
DOI: 10.1097/MEG.0000000000001190
19. Calleja JL, Macías J, Forns X, García F, Berenguer M, García Deltoro M, et al. Guidelines on treatment of hepatitis C virus infection. Spanish Association for the Study of the Liver (AEEH). Gastroenterol Hepatol 2018;41:597-608.
DOI: 10.1016/j.gastrohep.2018.07.010
20. European Association for the Study of the Liver. EASL Recommendations on Treatment of Hepatitis C 2018. J Hepatol 2018;69:461-511.
DOI: 10.1016/j.jhep.2018.03.026
21. AASLD-IDSA HCV Guidance Panel. Hepatitis C Guidance 2018 Update: AASLD-IDSA Recommendations for testing, managing, and treating hepatitis C virus infection. Clin Infect Dis 2018;67:1477-92.
DOI: 10.1093/cid/ciy585
22. World Health Organization. Guidelines for the screening care and treatment of persons with chronic hepatitis C infection: Updated version, April 2016. /20.
23. Van der Meer AJ, Feld JJ, Hofer H, Almasio PL, Calvaruso V, Fernández-Rodríguez CM, et al. Risk of cirrhosis-related complications in patients with advanced fibrosis following hepatitis C virus eradication. J Hepatol 2017;66:485-93.
DOI: 10.1016/j.jhep.2016.10.017
24. Negro F, Forton D, Craxi A, Sulkowski MS, Feld JJ, Manns MP. Extrahepatic morbidity and mortality of chronic hepatitis C. Gastroenterology 2015;149:1345-60.
DOI: 10.1053/j.gastro.2015.08.035
25. Pascual-Argente N, Puig-Junoy J, Llagostera-Punzano A. Nonhealthcare costs of hepatitis C: A systematic review. Expert Rev Gastroenterol Hepatol 2018;12:19-30.
DOI: 10.1080/17474124.2017.1373016
26. Pascasio JM, Vinaixa C, Ferrer MT, Colmenero J, Rubin A, Castells L, et al. Clinical outcomes of patients undergoing antiviral therapy while awaiting liver transplantation. J Hepatol 2017;67:1168-76.
DOI: 10.1016/j.jhep.2017.08.008
27. Strong K, Wald N, Miller A, Alwan A, WHO Consultation Group. Current concepts in screening for noncommunicable disease: World Health Organization Consultation Group Report on methodology of noncommunicable disease screening. J Med Screen 2005;12:12-9.
DOI: 10.1258/0969141053279086
28. Harris R, Sawaya GF, Moyer VA, Calonge N. Reconsidering the criteria for evaluating proposed screening programs: Reflections from 4 current and former members of the U.S Preventive Services Task Force. Epidemiol Rev 2011;33:20-35.
DOI: 10.1093/epirev/mxr005
29. Ministerio de Sanidad y Política Social. Documento marco sobre cribado poblacional. Diciembre de 2010. Disponible en: https://www.mscbs.gob.es/profesionales/saludPublica/prevPromocion/documentomarcoCribado.htm.
30. Terrault NA, Pawlotsky JM, McHutchison J, Anderson F, Krajden M, Gordon S, et al. Clinical utility of viral load measurements in individuals with chronic hepatitis C infection on antiviral therapy. J Viral Hepat 2005;12:465-72.
DOI: 10.1111/j.1365-2893.2005.00615.x
31. Berenguer J. Elimination of hepatitis C virus in Spain: A pending challenge. Enferm Infecc Microbiol Clin 2018;36:323-4.
DOI: 10.1016/j.eimc.2018.03.001
32. Backus LI, Belperio PS, Shahoumian TA, Loomis TP, Mole LA. Real-world effectiveness and predictors of sustained virological response with all-oral therapy in 21,242 hepatitis C genotype-1 patients. Antivir Ther 2017;22:481-93.
DOI: 10.3851/IMP3117
33. Smith-Palmer J, Cerri K, Valentine W. Achieving sustained virologic response in hepatitis C: Systematic review of the clinical, economic and quality of life benefits. BMC Infect Dis 2015;15:19.
DOI: 10.1186/s12879-015-0748-8
34. Pellicoro A, Ramachandran P, Iredale JP, Fallowfield JA. Liver fibrosis and repair: Immune regulation of wound healing in a solid organ. Nat Rev Immunol 2014;14:181-94.
DOI: 10.1038/nri3623
35. Van der Meer AJ, Veldt BJ, Feld JJ, Wedemeyer H, Dufour JF, Lammert F, et al. Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis. JAMA 2012;308:2584-93.
DOI: 10.1001/jama.2012.144878
36. Morgan TR, Ghany MG, Kim HY, Snow KK, Shiffman ML, de Santo JL, et al. HALT-C Trial Group. Outcome of sustained virological responders with histologically advanced chronic hepatitis C. Hepatology 2010;52:833-44.
DOI: 10.1002/hep.23744
37. Coretti S, Romano F, Orlando V, Codella P, Prete S, di Brino E, et al. Economic evaluation of screening programs for hepatitis C virus infection: Evidence from literature. Risk Manag Healthc Policy 2015;8:45-54.
38. Coward S, Leggett L, Kaplan GG, Clement F. Cost-effectiveness of screening for hepatitis C virus: A systematic review of economic evaluations. BMJ Open 2016;6:e011821.
DOI: 10.1136/bmjopen-2016-011821
39. Midgard H, Weir A, Palmateer N, lo Re V3rd, Pineda JA, Macías J, et al. HCV epidemiology in high-risk groups and the risk of reinfection. J Hepatol 2016;65(1 Suppl):S33-45.
DOI: 10.1016/j.jhep.2016.07.012
40. Crespo J, Lázaro de Mercado P, Blasco Bravo AJ, Aguilera GA, García-Samaniego RJ, Eiros Bouza JM, et al. Diagnosis of hepatitis C virus infection in Spain: An opportunity to improve. Enferm Infecc Microbiol Clin 2019;37:231-8.
DOI: 10.1016/j.eimc.2018.05.016
41. Cabezas J, Vázquez IF, Llerena S, Carrión JA, Moya AG, Lens S, et al. FRI-225-Universal access to direct-acting antivirals treatment is not not enough to prevent late stage presentation of hepatitis C infection. J Hepatol 2019;70:e493-4.
DOI: 10.1016/S0618-8278(19)30970-3
42. Hill AM, Khan A, Nath A, Simmons K. ‘‘Diagnostic Burn-out’’ for hepatitis C: When will countries run out of diagnosed people to treat with DAAs? Hepatology 2017;66(Suppl 1):149-185. http://dx.doi.org/10.1002/hep.29501.
43. Hill A, Simmons B. The road to elimination of Hepatitis C: Analysis of SVR versus new HCV infections in 91 countries. Disponible en: http://www.natap.org/2017/AASLD/ AASLDNetCure%20Oct21X.pdf.
44. Buti M, Calleja JL, García-Samaniego J, Serra MA, Crespo J, Romero M, et al. Elimination of hepatitis C in Spain: Adaptation of a mathematical model based on the public health strategic plan for addressing hepatitis C in the National Health System. Med Clin (Barc) 2017;148:277-82.
DOI: 10.1016/j.medcli.2016.12.018
45. Terrault NA, Dodge JL, Murphy EL, Tavis JE, Kiss A, Levin TR, et al. Sexual transmission of hepatitis C virus among monogamous heterosexual couples: The HCV partners study. Hepatology 2013;57:881-9.
DOI: 10.1002/hep.26164
46. Benova L, Mohamoud YA, Calvert C, Abu-Raddad LJ. Vertical transmission of hepatitis C virus: Systematic review and metaanalysis. Clin Infect Dis 2014;59:765-73.
DOI: 10.1093/cid/ciu447
47. Lazarus JV, Bromberg DJ, del Amo AJ, Norgaard O, García Samaniego J, Casellas A, et al. Hepatitis C prevalence among the migrant population in Spain: A systematic review and metaanalysis. Enferm Infecc Microbiol Clin 2019;37:222-30.
DOI: 10.1016/j.eimc.2018.04.002
48. Alarcón-Linares E, Torres-Cantero A, Subirá C, Ramírez Rubio O, Crespo J, Lazarus JV, et al. Geographic analysis and estimation of hepatitis C cases in migrant populations living in Spain: Is a country-based screening strategy appropriate? Rev Esp Enferm Dig 2019;111:615-25.
49. Greenaway C, Makarenko I, Chakra CNA, Alabdulkarim B, Christensen R, Palayew A, et al. The effectiveness and cost-effectiveness of hepatitis C screening for migrants in the EU/EEA: A systematic review. Int J Environ Res Public Health 2018;15:pii:E2013.
DOI: 10.3390/ijerph15092013
50. Morales-Arráez D, Alonso-Larruga A, Díaz-Flores F, García Dopico JA, de Vera A, Quintero E, et al. Predictive factors for not undergoing RNA testing in patients found to have hepatitis C serology and impact of an automatic alert. J Viral Hepat 2019. http://dx.doi.org/10.1111/jvh.13122.
51. Martínez-Crespo E. Search for ANTI-hepatitis C virus positive patients lost in the health system: Analysis of the absence of referring and the abandonment of the patients. Hepatology 2018;68(Suppl 1):928A-9A.
DOI: 10.1016/S0168-8278(17)30872-3
52. Cimavilla M, Garrido-López S, Almohalla C, García-Pajares F, Torres-Yuste R, Peñas-Herrero I, et al. Is an active search program for HCV useful to increase the rate of treatment? Hepatology 66(Suppl);397A.
53. Sánchez Antolín G, Sañudo S, Jiménez T, Blanco Ledo AM, Martín Sobrino N, García Vela JM. Hepatitis C: un ejemplo de planificación estratégica desde un área sanitaria. En: XXI Congreso Nacional de Hospitales y Gestión Sanitaria. Santiago de Compostela, 8-10 de mayo; 2019.
54. Lazarus JV, Safreed-Harmon K, Thursz MR, Dillon JF, el-Sayed MH, Elsharkawy AM, et al. The micro-elimination approach to eliminating hepatitis C: Strategic and operational considerations. Semin Liver Dis 2018;38:181-92.
DOI: 10.1055/s-0038-1666841
55. Cuadrado A, Llerena S, Cobo C, Pallas JR, Mateo M, Cabezas J, et al. Microenvironment eradication of hepatitis C: A novel treatment paradigm. Am J Gastroenterol 2018;113:1639-1648.
DOI: 10.1038/s41395-018-0157-x
56. Llerena S, Mateo M, Cobo C, Cabezas J, Cuadrado A, Blasco AJ, et al. Eficiencia de un programa de telemedicina en el manejo de la hepatitis C en población reclusa [póster]. Gastroenterol Hepatol 2019.
57. Jiménez-Galán G, Alia-Alia C, Vegue-González M, García-Berriguete RM, Fernández-González F, Fernández-Rodríguez C, et al. The contribution of telemedicine to hepatitis C elimination in a correctional facility. Rev Esp Enferm Dig 2019;111:550-5.
DOI: 10.17235/reed.2019.6152/2018
58. Crespo J, Eiros Bouza JM, Blasco Bravo AJ, Lazaro de MP, Aguilera GA, García F, et al. The efficiency of several onestep testing strategies for the diagnosis of hepatitis C. Rev Esp Enferm Dig 2019;111:10-6.
59. Assoumou SA, Tasillo A, Leff JA, Schackman BR, Drainoni ML, Horsburgh CR, et al. Cost-effectiveness of one-time hepatitis C screening strategies among adolescents and young adults in primary care settings. Clin Infect Dis 2018;66:376-84.
DOI: 10.1093/cid/cix798
60. Chevaliez S, Pawlotsky JM. New virological tools for screening, diagnosis and monitoring of hepatitis B and C in resource-limited settings. J Hepatol 2018;69:916-26.
DOI: 10.1016/j.jhep.2018.05.017
61. Corma-Gómez A, Pineda JA. Hepatitis C virus infection in Spain: Challenges in the track to elimination. Enferm Infecc Microbiol Clin 2019;37:219-21.
DOI: 10.1016/j.eimc.2019.01.004
62. Sharafi H, Poustchi H, Azimian F, Tamadoni B, Ramezani R, Gouya MM, et al. Performance of a rapid diagnostic test for screening of hepatitis C in a real life prison setting. J Clin Virol 2019;113:20-3.
DOI: 10.1016/j.jcv.2019.02.005
63. Diagnóstico microbiológico en el lugar de asistencia del paciente. Disponible en: https://seimc.org/contenidos/documentoscientificos/procedimientosmicrobiologia/seimcprocedimientomicrobiologia66.pdf.
64. Vázquez-Moron S, Ardizone JB, Jiménez-Sousa MA, Bellon JM, Ryan P, Resino S. Evaluation of the diagnostic accuracy of laboratory-based screening for hepatitis C in dried blood spot samples: A systematic review and meta-analysis. Sci Rep 2019;9:7316.
DOI: 10.1038/s41598-019-41139-8
65. Muzembo BA, Mbendi NC, Nakayama SF. Systematic review with meta-analysis: Performance of dried blood spots for hepatitis C antibodies detection. Public Health 2017;153:128-36.
DOI: 10.1016/j.puhe.2017.08.008
Related articles

Editorial

Low risk, high cost: challenging the role of gastric cancer screening in low-prevalence countries

DOI: 10.17235/reed.2025.11087/2024

Original

Genetic map of Wilson disease in Spain - A great tool to improve diagnosis and screening

DOI: 10.17235/reed.2025.11005/2024

Editorial

Population screening for colorectal cancer in Spain - A public health success with remaining challenges

DOI: 10.17235/reed.2024.10774/2024

Original

Clinical factors influencing patency capsule excretion and confirmation in patients with intestinal patency

DOI: 10.17235/reed.2024.10706/2024

Special Article

Strategic analysis and recommendations of the Sociedad Española de Patología Digestiva (SEPD) regarding population-based screening programs for colorectal cancer in Spain

DOI: 10.17235/reed.2024.10458/2024

Letter

Current characteristics of patients with hepatitis C virus: results from an automated alert system

DOI: 10.17235/reed.2024.10366/2024

Original

Screening and risk of hepatocellular carcinoma in patients with advanced fibrosis after hepatitis C virus eradication

DOI: 10.17235/reed.2024.9945/2023

Letter

Is cervical dysplasia a major concern in females with inflammatory bowel disease? A Spanish retrospective study

DOI: 10.17235/reed.2023.9890/2023

Letter

Better prognosis of HCV patients diagnosed and treated with an automatic alert system

DOI: 10.17235/reed.2023.9835/2023

Letter

Dissemination of the automated alert system in the diagnosis and treatment of hepatitis C

DOI: 10.17235/reed.2023.9801/2023

Special Article

Oportunistic diagnosis based on age and hepatitis C virus clearance: an essential step to improve the overall health of the liver

DOI: 10.17235/reed.2022.9325/2022

Letter

Hepatitis C virus micro-elimination in vulnerable populations before and during a global pandemic

DOI: 10.17235/reed.2022.9275/2022

Special Article

Current state of telemedicine in the field of Hepatology in Spain: challenges, threats and next steps to follow for an intelligent digital transformation

DOI: 10.17235/reed.2022.8918/2022

Editorial

Risk of hepatocellular carcinoma in patients with chronic hepatitis c infection and stage 3 fibrosis after sustained virological response

DOI: 10.17235/reed.2022.8840/2022

Original

Hepatitis C virus infection screening reduces mortality and is cost-effective independently of the intervention test

DOI: 10.17235/reed.2022.8609/2022

Original

Outcomes of an automated alert system from Microbiology to link diagnosis to treatment in patients with hepatitis C virus

DOI: 10.17235/reed.2022.8716/2022

Original

A slowdown of hepatitis C diagnosis in high-prevalence groups and with decentralized diagnostic strategies during the COVID-19 pandemic

DOI: 10.17235/reed.2022.8412/2021

Original

Findings in the distal and proximal colon in colonoscopy screening after positive FIT and related pre-procedure factors

DOI: 10.17235/reed.2022.8409/2021

Editorial

Cases of liver disease lost in the health system: a call to action

DOI: 10.17235/reed.2021.8316/2021

Original

Active search for hepatitis C patients in primary care

DOI: 10.17235/reed.2021.8067/2021

Letter

Implementation of a hepatology and gastroenterology teleconsultation for our penitentiary center

DOI: 10.17235/reed.2021.7985/2021

Original

Experience in the treatment of hepatitis C with direct-acting antivirals in a foreign population at a high-immigration area

DOI: 10.17235/reed.2021.7830/2021

Letter

Chronic viral hepatitis C micro-elimination program using telemedicine. The Mexican experience

DOI: 10.17235/reed.2021.7829/2021

Letter

Telemedicine, time to change the paradigm of hepatitis C management: improve access and reduce costs In reference to: Chronic viral hepatitis C micro-elimination program using telemedicine. The Mexican experience, by Pérez Hernández et al.

DOI: 10.17235/reed.2021.7809/2021

Original

Hepatitis C in homeless people: reaching a hard-to-reach population

DOI: 10.17235/reed.2021.7737/2020

Letter

The Screening Guidelines for Hepatitis C Virus Infection as a milestone in the path towards hepatitis C virus elimination

DOI: 10.17235/reed.2021.7736/2020

Editorial

Screening guide for hepatitis C virus infection in Spain

DOI: 10.17235/reed.2020.7728/2020

Original

Resumption of endoscopy in the Galician colorectal cancer screening programme after the COVID-19 lock down: patient safety results

DOI: 10.17235/reed.2020.7647/2020

Original

Chronic hepatitis C patients lost in the system: predictive factors of non-referral or loss of follow-up in Hepatology units

DOI: 10.17235/reed.2020.7573/2020

Original

Chronic viral hepatitis C micro-elimination program using telemedicine. The Mexican experience

DOI: 10.17235/reed.2020.7425/2020

Original

Prevalence of hepatitis C in patients with non-affective psychotic disorders

DOI: 10.17235/reed.2020.7278/2020

Letter

Ribavirin monotherapy for the treatment of chronic hepatitis E in an immunosuppressed patient

DOI: 10.17235/reed.2020.7266/2020

Review

New non-invasive biomarkers for colorectal cancer screening

DOI: 10.17235/reed.2020.7233/2020

Original

Linkage to care strategy for the micro-elimination of hepatitis C among parenteral drug users on methadone replacement therapy in Gipuzkoa

DOI: 10.17235/reed.2020.7194/2020

Special Article

Strategy for the Elimination of Hepatitis C in Cantabria

DOI: 10.17235/reed.2020.7108/2020

Editorial

Reflex testing. A key tool for the elimination of hepatitis C

DOI: 10.17235/reed.2020.7201/2020

Letter

Hepatitis C and beta-thalassemia major in children: experience with glecaprevir/pibrentasvir

DOI: 10.17235/reed.2020.7092/2020

Original

Patients with hepatitis C lost to follow-up: ethical-legal aspects and search results

DOI: 10.17235/reed.2020.7077/2020

Original

Changes in the characteristics of hospital admissions due to decompensated cirrhosis in the era of direct-acting antivirals against hepatitis C virus

DOI: 10.17235/reed.2020.7024/2020

Original

Prevalence and detection of undiagnosed active hepatitis C virus infections in Navarre, Spain, 2017-2019

DOI: 10.17235/reed.2020.7000/2020

Original

Diabetes is not associated with an increased risk of hepatocellular carcinoma in patients with alcoholic or hepatitis C virus cirrhosis

DOI: 10.17235/reed.2020.6953/2020

Original

Recapture of patients with an incomplete diagnosis of hepatitis C virus infection

DOI: 10.17235/reed.2020.6944/2020

Original

Review of hepatitis C screening programs for immigrants in Spain from endemic countries

DOI: 10.17235/reed.2020.6916/2020

Letter

Spontaneous clearance of chronic hepatitis C in an immunocompetent patient

DOI: 10.17235/reed.2020.6909/2020

Letter

The development of type-1 autoimmune hepatitis after chronic hepatitis C (HCV) clearance by direct-acting antivirals (DAA)

DOI: 10.17235/reed.2020.6785/2019

Special Article

Principles for implementing a population screening strategy for hepatitis C in Spain

DOI: 10.17235/reed.2019.6768/2019

Letter

Successful evolution of morphea after hepatitis C virus eradication with direct-acting antiviral agent treatment

DOI: 10.17235/reed.2019.6461/2019

Original

Towards the elimination of hepatitis C: implementation of reflex testing in Andalusia

DOI: 10.17235/reed.2020.6370/2019

Original

Quality of life study in asymptomatic patients with hepatitis C

DOI: 10.17235/reed.2019.6339/2019

Original

Definition of the profiles of hepatitis C virus patients based on the identification of risky practices in Spain

DOI: 10.17235/reed.2019.6169/2019

Original

The contribution of telemedicine to hepatitis C elimination in a correctional facility

DOI: 10.17235/reed.2019.6152/2018

Original

Geographic analysis and estimation of hepatitis C cases in migrant populations living in Spain: is a country-based screening strategy appropriate?

DOI: 10.17235/reed.2019.6117/2018

Original

HCV eradication with all-oral therapy in cirrhotic HIV-coinfected patients: an observational study of early changes in liver function and fibrosis tests

DOI: 10.17235/reed.2019.6086/2018

Original

Long-term changes on health-related quality of life in patients with chronic hepatitis C after viral clearance with direct-acting antiviral agents

DOI: 10.17235/reed.2019.6063/2018

Letter

Acute seronegative hepatitis C: two case reports

DOI: 10.17235/reed.2019.5921/2018

Editorial

Colorectal cancer screening and survival

DOI: 10.17235/reed.2018.5870/2018

Original

The efficiency of several one-step testing strategies for the diagnosis of hepatitis C

DOI: 10.17235/reed.2018.5810/2018

Letter

Why anal cytology is not enough in a dysplasia screening program

DOI: 10.17235/reed.2018.5678/2018

Original

Hepatitis B virus in patients with chronic hepatitis C treated with direct antiviral agents

DOI: 10.17235/reed.2018.5667/2018

Letter

An outbreak of acute hepatitis due to the hepatitis A virus in 2017: are we witnessing a change in contagion risk factors?

DOI: 10.17235/reed.2018.5633/2018

Letter

Anal intraepitelial neoplasia: how and for who do we perform a screening program?

DOI: 10.17235/reed.2018.5616/2018

Original

Economic evaluation of a population strategy for the treatment of chronic hepatitis C with direct-acting antivirals

DOI: 10.17235/reed.2018.5605/2018

Case Report

Healing of autoimmune hepatitis associated with hepatitis C virus infection treated with direct-acting antivirals

DOI: 10.17235/reed.2018.5528/2018

Original

Screening-detected colorectal cancers show better long-term survival compared with stage-matched symptomatic cancers

DOI: 10.17235/reed.2018.5509/2018

Editorial

Disruptive therapeutic innovation and the opportunity to eliminate a chronic disease – The issue of chronic hepatitis C in Spain

DOI: 10.17235/reed.2017.5384/2017

Editorial

Point of care testing for paediatric coeliac disease in the new ESPGHAN era

DOI: 10.17235/reed.2017.5337/2017

Original

Effectiveness of direct-acting antiviral therapy in patients with a HCV/HIV coinfection. A multicenter cohort study

DOI: 10.17235/reed.2017.5210/2017

Case Report

Liver transplantation in hemophilia A and von Willebrand disease type 3: perioperative management and post-transplant outcome

DOI: 10.17235/reed.2018.5204/2017

Original

Value and innovation of direct-acting antivirals: long-term health outcomes of the strategic plan for the management of hepatitis C in Spain

DOI: 10.17235/reed.2017.5063/2017

Editorial

Lower morbidity and improved outcomes in patients with screen-detected colorectal cancer

DOI: 10.17235/reed.2017.5107/2017

Letter to the Editor

Hepatitis with a multiple etiology in HIV-positive men who have sexual relations with other men

DOI: 10.17235/reed.2017.5033/2017

Original

Anal cytology, histopathology and anoscopy in an anal dysplasia screening program: is anal cytology enough?

DOI: 10.17235/reed.2017.4913/2017

Editorial

Target population for the screening of human papillomavirus (HPV) and anal carcinoma precursor lesions – Results from a pilot study in HIV-infected males with sexual risk factors

DOI: 10.17235/reed.2017.4939/2017

Case Report

Liver metastasis from neuroendocrine carcinoma after the use of the new direct-action antivirals against hepatitis C virus in a patient with past history of hepatocellular carcinoma

DOI: 10.17235/reed.2017.4772/2016

Original

Cost-effectiveness of a hepatitis B virus screening strategy to prevent reactivation in patients with hematologic neoplasms

DOI: 10.17235/reed.2017.4693/2016

Letter to the Editor

Hepatocellular carcinoma in patients without advanced fibrosis after HCV eradication antiviral treatment

DOI: 10.17235/reed.2017.4677/2016

Original

Is it possible to predict the presence of colorectal cancer in a blood test? A probabilistic approach method

DOI: 10.17235/reed.2017.4645/2016

Original

The impact of screening on short-term outcome after surgery for colorectal cancer

DOI: 10.17235/reed.2017.4569/2016

Original

Malnutrition risk questionnaire combined with body composition measurement in malnutrition screening in inflammatory bowel disease

DOI: 10.17235/reed.2016.4557/2016

Digestive Diseases Image

Hepatocellular carcinoma presenting with Budd-Chiari syndrome, right atrial thrombus and pulmonary emboli

Original

Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain

DOI: 10.17235/reed.2017.4274/2016

Original

Effectiveness of three interventions to improve participation in colorectal cancer screening

DOI: 10.17235/reed.2016.4048/2015

Original

Enhanced flat adenoma detection rate with high definition colonoscopy plus i-scan for average-risk colorectal cancer screening

DOI: 10.17235/reed.2016.4008/2015

Review

Causes of treatment failure for hepatitis C in the era of direct-acting antiviral therapy

DOI: 10.17235/reed.2015.3894/2015

Original

Efficacy and safety of simeprevir in combination with peginterferon and ribavirin for patients with hepatitis C genotype 1 infection: A meta-analysis of randomized trials

DOI: 10.17235/reed.2015.3840/2015

Citation tools
Crespo J, Albillos A, Buti M, Calleja J, García Samaniego J, Hernández Guerra M, et all. Elimination of hepatitis C. Positioning document of the Spanish Association for the Study of the Liver (AEEH). 6700/2019


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 3495 visits.
This article has been downloaded 864 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Accepted: 24/10/2019

Online First: 28/10/2019

Published: 07/11/2019


Share
This article has been rated by 1 readers.
Reader rating:
Valora este artículo:




Home
Articles
Current issues
Previous issues
Most read articles
Clinical guidelines
Reviews
Topic collection
Submit a manuscript
Submit a manuscript
Information for authors
Language editing services
Editorial time – Publication time
ORCID guide
PubMed guide
Journal info
About the journal
Editorial board
For reviewers
For advertisers
REED centenary
Open access
Articles in press
REED awards
Home
Articles
Current issues
Previous issues
Most read articles
Clinical guidelines
Reviews
Topic collection
Submit a manuscript
Submit a manuscript
Information for authors
Language editing services
Editorial time – Publication time
ORCID guide
PubMed guide
Journal info
About the journal
Editorial board
For reviewers
For advertisers
REED centenary
Open access
Articles in press
REED awards
Home
Articles
Current issues
Previous issues
Most read articles
Clinical guidelines
Reviews
Topic collection
Submit a manuscript
Submit a manuscript
Information for authors
Language editing services
Editorial time – Publication time
ORCID guide
PubMed guide
Journal info
About the journal
Editorial board
For reviewers
For advertisers
REED centenary
Open access
Articles in press
REED awards
Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2025 y Creative Commons. The Spanish Journal of Gastroenterology