Year 2025 / Volume 117 / Number 6
Original
The predictive value of miR-132-3p combined with Prognostic Nutritional Index (PNI) for gastric cancer prognosis

303-312

DOI: 10.17235/reed.2024.10882/2024

Jing Qin, Bixia Chen, Yan-Hui Sun, Xiao-Xiao Wang, Cong Wu, Caihua Zhang,

Abstract
Background: previous studies have demonstrated that the Prognostic Nutritional Index (PNI) can predict the prognosis of gastric cancer (GC) patients. However, few studies have focused on the auxiliary role of miRNA in predicting the prognosis of GC. Objective: this study aimed to clarify the role of the combined use of miR-132-3p and PNI to predict the prognosis of GC patients. Methods: a total of 126 patients with GC who underwent surgical treatment at our institution were included in the study. The qRT-PCR data was used to assess the expression of miR-132-3p in tumor and adjacent normal tissues. The predictive value of miR-132-3p and PNI for postoperative prognosis, and the relationships between miR-132-3p, PNI, and preoperative clinical characteristics, were assessed using ROC, χ², Kaplan-Meier survival analysis, and Cox regression analysis. Bioinformatics analyses and dual-luciferase reporter assay were conducted to elucidate the biological function of miR-132-3p and the underlying molecular mechanisms. Results: miR-132-3p was downregulated in GC tumor tissues and significantly and positively correlated with PNI. Both miR-132-3p and PNI were significantly associated with TNM stage and lymph node metastasis. Postoperative GC patients with low miR-132-3p expression and low PNI had lower survival rates, and both were independent risk factors for poor prognosis. The combination of miR-132-3p and PNI demonstrated better sensitivity and specificity to predict postoperative prognosis than either indicator alone. miR-132-3p may be involved in DNA damage response, angiogenesis, and immune response associated with GC development. MAPK1 was identified as a target gene regulated by miR-132-3p in GC. Conclusion: the combination of miR-132-3p and PNI can effectively improve the predictive value of postoperative prognosis in GC patients. The combination of miR-132-3p and PNI, which are strongly correlated with pathological characteristics and can be readily obtained, has a potential clinical applicability in the prognosis of patients with GC.
Lay Summary
Gastric cancer has a high incidence and mortality rate. For most patients, surgery remains the primary treatment. Preoperative malnutrition and inflammation increase the risk of postoperative complications and ultimately lead to poor prognosis. The objective of this study was to find new tools for accurate prognostic assessment of gastric cancer patients. In this study, a comprehensive analysis of clinical data was conducted to evaluate the relationship between miR-132-3p expression and prognostic nutritional index and the pathological features of patients with gastric cancer. The combined predictive ability of miR-132-3p and the prognostic nutritional index on patient prognosis was further analyzed. Furthermore, the potential mechanism of miR-132-3p involved in gastric cancer progression was explored by bioinformatics analysis methods and in vitro experiments. The expression of miR-132-3p and the prognostic nutritional index were found to be significantly correlated with pathological features linked to poor prognosis in patients. Low expression of miR-132-3p and low prognostic nutritional index were associated with reduced survival in patients with gastric cancer. The combination of miR-132-3p and the prognostic nutritional index had better prognostic value than either indicator alone. miR-132-3p may be involved in the progression of gastric cancer. The combined use of miR-132-3p and the prognostic nutritional index is important in assessing patient prognosis. The evaluation of prognostic nutritional index and miR-132-3p expression may facilitate the development of personalized treatment strategies for patients.
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Qin J, Chen B, Sun Y, Wang X, Wu C, Zhang C, et all. The predictive value of miR-132-3p combined with Prognostic Nutritional Index (PNI) for gastric cancer prognosis. 10882/2024


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Publication history

Received: 22/10/2024

Accepted: 12/12/2024

Online First: 09/01/2025

Published: 10/06/2025

Article Online First time: 79 days

Article editing time: 231 days


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