Year 2017 / Volume 109 / Number 8
Letter to the Editor
McKittrick-Wheelock syndrome: unusual, but potentially lethal

597-598

DOI: 10.17235/reed.2017.4805/2016

María López Álvarez, Jesús Ángel Yañéz López, Aldara Naveiras Calvo,

Abstract
McKittrick-Wheelock syndrome is characterized by extracellular volume depletion and severe fluid and electrolyte imbalance caused by secretory tumors of the rectum, usually villous adenomas. Patients usually present signs of dehydration, hyponatremia, hypokalemia, and prerenal azotemia due to the chronic diarrhea, rich in ions and water. Since this is a potencially lethal entity without treatment, and a very unusual condition, we report a clinical case. Treatment consists in surgical resection of the tumor, although endoscopy polypectomy has also been reported
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References
McKittrick LS, Wheelock FC. Carcinoma of the colon. 1954. Dis Colon Rectum. 1997
Bruno A, Chimienti D, Montanaro A et al. The mckittrick-wheelock syndrome: a rare cause of severe hydroelectrolyte disorders and acute renal failure. Case Rep Nephrol. 2011:765689
Watari J, Sakurai J, Morita T et al. A case of Cronkhite-Canada syndrome complicated by McKittrick-Wheelock syndrome associated with advanced villous adenocarcinoma. Gastrointest Endosc. 2011;73(3):624-6.
Ohara Y, Toyonaga T, Watanabe D et al. Electrolyte depletion syndrome (McKittrick-Wheelock syndrome) successfully treated by endoscopic submucosal dissection. Clin J Gastroenterol. 2015;8(5):280-4
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López Álvarez M, Yañéz López J, Naveiras Calvo A. McKittrick-Wheelock syndrome: unusual, but potentially lethal. 4805/2016


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Publication history

Received: 20/12/2016

Accepted: 12/01/2017

Online First: 19/06/2017

Published: 31/07/2017

Article Online First time: 181 days

Article editing time: 223 days


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