Year 2025 / Volume 117 / Number 6
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Simultaneous diagnosis of well-differentiated neuroendocrine tumor and gastrointestinal stromal tumor of the stomach: an infrequent finding

340-341

DOI: 10.17235/reed.2023.9984/2023

Álvaro Yagüe Parada, Silvana Nora Scaletti Cárdenas, Paula Vázquez de Parga Coca, Marina Castellanos González,

Abstract
We present the case of a 75-year-old female patient who was referred to gastroenterology consultation due to vitamin B12 deficiency. Anti-parietal cell and anti-intrinsic factor antibodies were positive. An upper gastrointestinal endoscopy was performed for the suspicion of autoimmune gastritis, identifying in the greater curvature of the gastric corpus a 25 mm spherical, subepithelial lesion, suggestive of gastrointestinal stromal tumour (GIST). A 2 mm sessile polyp was observed adjacent to it. Biopsies from both lesions were taken. Histological examination of the submucosal lesion showed mucosa with neuroendocrine cell dysplasia. The polypoid lesion was compatible with a well-differentiated neuroendocrine tumour (G1) with affected margins. A SPECT-CT scan was performed, showing the lesion compatible with GIST expression of somatostatin receptors. There were no signs of distant extension. Using endoscopic ultrasound, the subepithelial lesion was described as a hypoechoic bulge of the fourth layer, measuring 25 x 18 mm. It was not possible to visualize the polyp. EUS-guided fine needle aspiration was performed, and cytology was negative for malignancy. Finally, it was decided to perform an atypical, laparoscopic gastric greater curvature resection. Neuroendocrine tumours (NETs) are epithelial neoplasms derived from cells of the diffuse neuroendocrine system. Gastrointestinal stromal tumours (GISTs), although they represent 1-3% of gastrointestinal neoplasms, are the most common mesenchymal tumours, arising from interstitial Cajal cells. The synchronous finding in the stomach of a well-differentiated NET and a GIST is rare, having been described in a low percentage of cases.
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References
1. Samaras VD, Foukas PG, Triantafyllou K, Leontara V, Tsapralis D, Tsompanidi EM, Machairas A, Panayiotides IG. Synchronous well differentiated neuroendocrine tumour and gastrointestinal stromal tumour of the stomach: a case report. BMC Gastroenterol. 2011 Mar 24;11:27.
2. Lin YL, Wei CK, Chiang JK, Chou AL, Chen CW, Tseng CE. Concomitant gastric carcinoid and gastrointestinal stromal tumors: a case report. World J Gastroenterol. 2008 Oct 21;14(39):6100-3.
3. Kövér E, Faluhelyi Z, Bogner B, Kalmár K, Horváth G, Tornóczky T. Dual tumours in the GI tract: synchronous and metachronous stromal (GIST) and epithelial/neuroendocrine neoplasms (in Hungarian with English abstract) Magy Onkol. 2004;48(4):315–21.
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Yagüe Parada Á, Scaletti Cárdenas S, Vázquez de Parga Coca P, Castellanos González M. Simultaneous diagnosis of well-differentiated neuroendocrine tumor and gastrointestinal stromal tumor of the stomach: an infrequent finding. 9984/2023


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Publication history

Received: 25/09/2023

Accepted: 29/09/2023

Online First: 26/10/2023

Published: 10/06/2025

Article Online First time: 31 days

Article editing time: 624 days


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