Year 2026 / Volume 118 / Number 1
Letter
Ruptured pancreatic carcinosarcoma – A case of extended survival following surgical resection and chemotherapy

60-62

DOI: 10.17235/reed.2024.10856/2024

Yekai Zhou, Xiaorong Chen, Jie Li, Fang Luo,

Abstract
We present a rare case of ruptured pancreatic carcinosarcoma in a 56-year-old male who underwent radical surgery and adjuvant chemotherapy. Despite the typical poor prognosis associated with this aggressive tumor, the patient achieved an overall survival of 20 months postoperatively. This case emphasizes the challenges in diagnosing and managing pancreatic carcinosarcoma and highlights the potential benefits of aggressive surgical and chemotherapeutic interventions in achieving extended survival
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References
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1.Zhu, W. Y.; Liu, T. G.; Zhu, H., Long-term recurrence-free survival in a patient with pancreatic carcinosarcoma: a case report with a literature review. Med Oncol 2012, 29 (1), 140-3.
2.Yamazaki, K., A unique pancreatic ductal adenocarcinoma with carcinosarcomatous histology, immunohistochemical distribution of hCG-beta, and the elevation of serum alpha-feto-protein. J Submicrosc Cytol Pathol 2003, 35 (4), 343-9.(1)
3.Millis, J. M.; Chang, B.; Zinner, M. J.; Barsky, S. H., Malignant mixed tumor (carcinosarcoma) of the pancreas: a case report supporting organ-induced differentiation of malignancy. Surgery 1994, 115 (1), 132-7.
4.van den Berg, W.; Tascilar, M.; Offerhaus, G. J.; Albores-Saavedra, J.; Wenig, B. M.; Hruban, R. H.; Gabrielson, E., Pancreatic mucinous cystic neoplasms with sarcomatous stroma: molecular evidence for monoclonal origin with subsequent divergence of the epithelial and sarcomatous components. Mod Pathol 2000, 13 (1), 86-91.
5.Kim, H. S.; Joo, S. H.; Yang, D. M.; Lee, S. H.; Choi, S. H.; Lim, S. J., Carcinosarcoma of the pancreas: a unique case with emphasis on metaplastic transformation and the presence of undifferentiated pleomorphic high-grade sarcoma. J Gastrointestin Liver Dis 2011, 20 (2), 197-200.
6.Szukala, S. A.; Marks, J. R.; Burchette, J. L.; Elbendary, A. A.; Krigman, H. R., Co-expression of p53 by epithelial and stromal elements in carcinosarcoma of the female genital tract: an immunohistochemical study of 19 cases. Int J Gynecol Cancer 1999, 9 (2), 131-136.
7.Jia, Z.; Zhang, K.; Huang, R.; Zhou, X.; Jiang, L., Pancreatic carcinosarcoma with rare long-term survival: Case report and review of the literature. Medicine (Baltimore) 2017, 96 (4), e5966.
8.Liu, X.; Wang, H.; Ying, R., Comparative study of sarcomatoid carcinoma and carcinosarcoma of the pancreas: a population-based study. Transl Cancer Res 2022, 11 (7), 2061-2069.
9.Collisson, E. A.; Sadanandam, A.; Olson, P.; Gibb, W. J.; Truitt, M.; Gu, S. D.; Cooc, J.; Weinkle, J.; Kim, G. E.; Jakkula, L.; Feiler, H. S.; Ko, A. H.; Olshen, A. B.; Danenberg, K. L.; Tempero, M. A.; Spellman, P. T.; Hanahan, D.; Gray, J. W., Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat Med 2011, 17 (4), 500-U140.
10.Zhu LX, Wang GS, Fan ST. Spontaneous rupture of hepatocellular carcinoma. Br J Surg 1996; 83: 602-607
11.Tanaka T, Yamanaka N, Oriyama T, Furukawa K, OkamotoE. Factors regulating tumor pressure in hepatocellularcarcinoma and implications for tumor spread. Hepatology 1997; 26: 283-287
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Zhou Y, Chen X, Li J, Luo F. Ruptured pancreatic carcinosarcoma – A case of extended survival following surgical resection and chemotherapy. 10856/2024


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Publication history

Received: 11/10/2024

Accepted: 27/10/2024

Online First: 12/11/2024

Published: 14/01/2026

Article Online First time: 32 days

Article editing time: 460 days


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