Year 2022 / Volume 114 / Number 7
Letter
Mesalazine induced interstitial pneumonitis in the COVID era

429-430

DOI: 10.17235/reed.2022.8635/2021

Ana Aparicio Serrano, Elma Gallego Jiménez, Javier Castro Rodríguez, Pilar Soto Escribano, Eva Iglesias Flores, Sandra Marín Pedrosa, José Manuel Benítez,

Abstract
Mesalazine is the most widely used aminosalicylate for induction and maintenance of remission in patients with mild-to-moderate ulcerative colitis (UC). Drug-induced hypersensitivity pneumonitis is considered very rare (<1/10.000 patients). Due to its rarity and the scarce cases reported, mesalazine-induced lung injury needs to be highly suspected in a patient with onset of respiratory symptoms and UC under treatment with salicylates. It should make the clinician formulate a differential diagnosis that includes not only infections (tuberculosis, bacterial...) or the inflammatory bowel disease itself, but also the current coronavirus disease 2019 (COVID‐19) since their clinical and radiological manifestations may be very similar.
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References
1. Sicilia B, García-López S, González-Lama Y, et al, en representación del Grupo Español de Trabajo de Enfermedad de Crohn y Colitis Ulcerosa or Spanish Group for Working on Crohn’s Disease and Ulcerative Colitis (GETECCU). Guía GETECCU 2020 para el tratamiento de la colitis ulcerosa. Elaborada con metodología GRADE. Gastroenterol Hepatol. 2020;43(1):1-57.
2. Kotsiou OS, Gourgoulianis KI. A case report of mesalazine-induced lung injury: A reversible drug side effect. Respir Med Case Rep. 2019;27:100865. PMID: 31193970. DOI: 10.1016/j.rmcr.2019.100865
3. Kim JH, Lee JH, Koh ES, et al. Acute eosinophilic pneumonia related to a mesalazine suppository. Asia Pac Allergy. 2013;3(2):136-9.
4. Oi H, Suzuki A, Yamano Y, et al. Mesalazine-induced lung injury with severe respiratory failure successfully treated with steroids and non-invasive positive pressure ventilation. Respir Med Case Rep. 2020;31:101157.
5. Martí-Aguado D, Ballester MP, Mínguez M. Risk factors and management strategies associated with non-response to aminosalicylates as a maintenance treatment in ulcerative colitis. Rev Esp Enferm Dig. 2021;113(6):447-453.
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Aparicio Serrano A, Gallego Jiménez E, Castro Rodríguez J, Soto Escribano P, Iglesias Flores E, Marín Pedrosa S, et all. Mesalazine induced interstitial pneumonitis in the COVID era. 8635/2021


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Publication history

Received: 22/01/2022

Accepted: 01/02/2022

Online First: 18/02/2022

Published: 07/07/2022

Article Online First time: 27 days

Article editing time: 166 days


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