Year 2015 / Volume 107 / Number 8
Letter to the Editor
Gastrointestinal manifestations in Cowden syndrome. Screening recommendations

521-523

Helena León-Brito, Susana Oquiñena-Legaz, Rosa Iglesias-Picazo, María Fraile-González, Irene Aresté-Anduaga, M. Rosario Aznárez-Barrio, Antonio M. Pueyo-Royo and Ana C. Guerra-Lacunza

Abstract
Dear Editor,
Cowden syndrome (CS) or multiple hamartoma syndrome is a rare entity related to the PTEN gene. Its classic phenotype includes hamartomatous lesions in any localization – these patients have mainly cutaneous lesions but also gastrointestinal lesions are frequent. Other tumors related to CS are breast, thy- roid and endometrial malignant neoplasms for which specific screening recommendations have been established (1,2). Recent- ly, series of CS patients with gastrointestinal polyps of other nature as well as colonic adenocarcinomas have been published (3,4). Thus, colorectal cancer (CRC) is currently considered one of the diagnostic criteria of the PTEN hamartoma tumor syn- drome spectrum (2) of which CS is a part (5). This has implied the novel inclusion of colorectal cancer (CRC) screening as part of the recommendations of some of the clinical guidelines.
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Helena León-Brito, Susana Oquiñena-Legaz, Rosa Iglesias-Picazo, María Fraile-González, Irene Aresté-Anduaga, M. Rosario Aznárez-Barrio, Antonio M. Pueyo-Royo and Ana C. Guerra-Lacunza. Gastrointestinal manifestations in Cowden syndrome. Screening recommendations. 521-523


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