Year 2017 / Volume 109 / Number 11
Letter to the Editor
Conjugated hyperbilirubinemia after surgery. A diagnosis of Dubin-Johnson syndrome confirmed by genetic testing

801-802

DOI: 10.17235/reed.2017.4989/2017

Maria Luisa Baranguán Castro, Ruth García Romero, María Dolores Miramar Gallart,

Abstract
Dubin-Johnson syndrome is a rare benign inherited disorder, caused by mutations in ABCC2 gen, and it is characterized by predominantly conjugated hyperbilirubinemia that can be increased by intercurrent infectious illnesses or surgical procedures. We report the case of a 10 year-old patient who showed, after a surgical procedure for peritonitis due to appendicitis, jaundice and predominantly conjugated hyperbilirubinemia, and he was diagnosed with Dubin-Johnson syndrome by genetic testing.
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References
1. Erlinger S, Arias IM, Dhumeaux D. Inherited disorders of bilirubin transport and conjugation: New insights into molecular mechanisms and consequences. Gastroenterology. 2014;146:1625–1638.
2. Radlovic N. Hereditary hyperbilirubinemias. Srp Arh Celok Lek. 2014;142:257–260.
3. Nies AT, Keppler D. The apical conjugate efflux pump ABCC2 (MRP2). Pflugers Arch Eur J Physiol. 2007;453:643–659.
4. Strassburg CP. Hyperbilirubinemia syndromes (Gilbert-Meulengracht, Crigler-Najjar, Dubin-Johnson, and Rotor syndrome). Best Pract Res Clin Gastroenterol. 2010;24:555–571.
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Baranguán Castro M, García Romero R, Miramar Gallart M. Conjugated hyperbilirubinemia after surgery. A diagnosis of Dubin-Johnson syndrome confirmed by genetic testing. 4989/2017


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Publication history

Received: 03/04/2017

Accepted: 12/06/2017

Online First: 16/10/2017

Published: 02/11/2017

Article revision time: 64 days

Article Online First time: 196 days

Article editing time: 213 days


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