Year 2022 / Volume 114 / Number 6
Letter
Upper gastrointestinal bleeding secondary to toxicity by anthracyclines, cytarabine and methotrexate in a patient with acute lymphoblastic leukemia

363-364

DOI: 10.17235/reed.2022.8639/2022

Alejandro García Martínez, Juan Cristóbal Aguilar Martínez, Lidia Campos Gonzaga, Daniel Mateos Millán,

Abstract
A 60-year-old male patient with no medical history but acute lymphoblastic leukemia was admitted in the hematology ward for chemotherapy treatment (methotrexate, cytarabine, fludarabine and idarubicin). Approximately six days after finishing this chemotherapy, the patient began with symptoms of upper gastrointestinal bleeding (hematemesis and melena). Gastroscopy revealed erosive esophagitis, gastritis and duodenitis, as well as Forrest III ulcers in the duodenal bulb and multiple Forrest IIb ulcers in the second portion of the duodenum. Given the multiplicity of lesions, medical treatment with high doses of folinic acid, intravenous omeprazole, and transfusion of blood products was decided, with favorable evolution of the gastrointestinal bleeding. However, the patient died of respiratory infection.
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References
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Citation tools
García Martínez A, Aguilar Martínez J, Campos Gonzaga L, Mateos Millán D. Upper gastrointestinal bleeding secondary to toxicity by anthracyclines, cytarabine and methotrexate in a patient with acute lymphoblastic leukemia. 8639/2022


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Publication history

Received: 23/01/2022

Accepted: 24/01/2022

Online First: 01/02/2022

Published: 07/06/2022

Article Online First time: 9 days

Article editing time: 135 days


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