Year 2012 / Volume 104 / Number 11
Editorial
Genes and populations in susceptibility to celiac disease

pp. 563-565- 2012

José Antonio Garrote Adrados y Eduardo Arranz Sanz

Abstract
It was in 1996 that Zhong (1) published the first pangenomic association study related to celiac disease (CD). Since then, as Professor Ludwig Sollid was to write in an editorial in 2008 (2), gene hunting season remained open as regards to CD. The association between this condition and MHC genes was well known but it was only a few years earlier that at-risk HLA-DQB1 and DQA1 alleles had been specifically defined (3). However, while HLA is a key region for CD susceptibility, it only repre- sents around 40% of the genetic budget. Almost ten years after the paper by Zhong, Monsuur et al. found an association between CD and gene variants for an unconven- tional myosin, MYO9B (4), in a hot spot on chromosome 19 (19p13.1) that had been previously defined by the same team (5). This is not merely another finding in the race towards understanding susceptibility genes in this disease; in addition to being an early fruit of modern genomic platforms in the study of complex genetic disorders, it reveals the contribution of genes not directly associated with the immune system to the pathogenesis of CD, as it relates this condition to a gene potentially involved in epithelial permeability...
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José Antonio Garrote Adrados y Eduardo Arranz Sanz. Genes and populations in susceptibility to celiac disease. 563-565- 2012


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