Year 2015 / Volume 107 / Number 8
Notas
Fanconi syndrome and chronic renal failure in a chronic hepatitis B monoinfected patient treated with tenofovir

512-514

Pedro Magalhães-Costa, Leopoldo Matos, Pedro Barreiro and Cristina Chagas

Abstract
ABSTRACT
Tenofovir disoproxil fumarate (TDF) is one of the first-line treatment options in chronic hepatitis B (CHB). Despite its efficacy in suppressing viral load and a high resistance barrier, long life maintenance therapy is required. Registration studies demonstrated TDF to be a safe drug. However, post-marketing experience reported cases of serious nephrotoxicity associated with hypophosphatemia, osteomalacia and, even more recently, Fanconi syndrome associated with TDF therapy in CHB monoinfected patients.
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Pedro Magalhães-Costa, Leopoldo Matos, Pedro Barreiro and Cristina Chagas. Fanconi syndrome and chronic renal failure in a chronic hepatitis B monoinfected patient treated with tenofovir. 512-514


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