Year 2014 / Volume 106 / Number 4
Original
A Spanish multicenter study to estimate the prevalence and incidence of chronic pancreatitis and its complications

239-245

J. Enrique Domínguez-Muñoz1, Alfredo Lucendo2, L. Fernando Carballo3, Julio Iglesias-García1 y José María Tenías4

Abstract
Background and objective: No nation-wide epidemiological
study on the incidence and prevalence of chronic pancreatitis (CP)
had been thus far carried out in Spain. Our goal is to estimate
the prevalence and incidence of CP, as well as to determine the
diagnostic and therapeutic criteria used in Spanish pancreas units.
Methods: An observarional, descriptive study of hospital
pancreas units in Spain. CP-related epidemiology, etiology,
manifestations, diagnostic tests, functional complications, and
treatments were all assessed using a structured questionnaire.
Overall results were estimated by weighting cases in each site.
Results: Information was collected from six pancreas units
with a sample frame of 1,900,751 inhabitants. Overall prevalence
was 49.3 cases per 105 population (95 % CI, 46 to 52) and
incidence was 5.5 cases per 105 inhabitant-years (95 % CI, 5.4
to 5.6). Most common etiologies included tobacco and alcoholism,
which were associated with three in every four cases. The most
prevalent symptoms were recurring pain (48.8 %) and chronic
abdominal pain (30.6 %). The most widely used diagnostic method
was echoendoscopy (79.8 %), CT (computerized tomography)
(58.7 %), and MRI (magnetic resonance imaging)/MRCP (magnetic
resonance cholangiopancreatography) (55.9 %). Most prevalent
morphologic findings included calcifications (35 %) and pseudocysts
(27 %). Exocrine (38.8 %) and endocrine (35.2 %) pancreatic
insufficiency had both a similar frequency. Treatments used were
rather heterogeneous among sites, with enzyme replacement
therapy (40.7 %) and insulin (30.9 %) being most commonly used.
Conclusions: Pancreas units amass a significant number of
both prevalent and incident CP cases. Patients seen in these units
share a similar typology, and differences between units are greater
regarding diagnostic and therapeutic strategies.
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J. Enrique Domínguez-Muñoz1, Alfredo Lucendo2, L. Fernando Carballo3, Julio Iglesias-García1 y José María Tenías4. A Spanish multicenter study to estimate the prevalence and incidence of chronic pancreatitis and its complications. 239-245


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