Year 2025 / Volume 117 / Number 5
Review
Estimation of liver fibrosis using elastography in cholestatic diseases: systematic review and meta-analysis

265-273

DOI: 10.17235/reed.2023.9254/2022

Natalia Marcos Carrasco, Alejandro López Jerez, Elena Garrido, Miguel García González,

Abstract
Introduction: staging fibrosis extent in liver disease is highly relevant for appropriate management. Liver biopsy remains the reference standard for assessment, but noninvasive methods such as elastography are becoming increasingly accurate and relevant. However, evidence regarding elastography in cholestatic diseases is lower than in other etiologies. Methods: we searched MEDLINE, EMBASE and Web of Science for publications on the diagnostic accuracy of transient elastography and sonoelastography in cholestatic diseases (PBC and PSC) using biopsy as the reference standard. A systematic review and meta-analysis of the results was then carried out. Results: a total of 13 studies were included. Using transient elastography in PBC sensitivity and specificity were estimated to be 0.76 and 0.93; 0.88 and 0.9; and 0.91 and 0.95 for ≥ F2, ≥ F3 and = F4, respectively. For sonoelastography in PBC sensitivity and specificity estimates were 0.79 and 0.82; 0.95 and 0.86; and 0.94 and 0.85 for ≥ F2, ≥ F3 y = F4, respectively. In PSC, transient elastography had a sensivity and specificity of 0.76 and 0.88; 0.91 and 0.86; and 0.71 and 0.93 for ≥ F2, ≥ F3 and = F4, respectively. Conclusion: elastography has adequate diagnostic accuracy in the assessment of fibrosis stages in cholestatic liver diseases.
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Marcos Carrasco N, López Jerez A, Garrido E, García González M. Estimation of liver fibrosis using elastography in cholestatic diseases: systematic review and meta-analysis . 9254/2022


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Publication history

Received: 03/10/2022

Accepted: 12/05/2023

Online First: 26/06/2023

Published: 08/05/2025

Article revision time: 211 days

Article Online First time: 266 days

Article editing time: 948 days


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