Year 2013 / Volume 105 / Number 3
Notas
Collagenous sprue: Don’t forget connective tissue in chronic diarrhea evaluation

pp. 171-174

Victoria Busto Bea, Laura Crespo Pérez, Noemí García Miralles, Luis Ruiz del Árbol Olmos y Ana Cano Ruiz

Abstract
Collagenous sprue is a rare disease of the small bowel characterized by mucosal atrophy and excessive subepithelial collagen deposition. The etiology remains unclear and the diagnosis is based upon patient’s clinical picture and anatomopathological findings. Clinically, collagenous sprue is characterized by persistent diarrhoea, severe malabsorption, multiple nutrient deficiencies and progressive weight loss. Differential diagnosis includes celiac disease, which is mandatory to rule out because of their frequent association. Gluten-free diet is the first therapeutic step, but it usually is not effective. However, recent studies show high success rates with immunomodulators, mainly corticosteroids. We report the case of a patient presenting with chronic diarrhea and severe malabsorption who was diagnosed
with collagenous sprue, with no response to gluten free diet, but with excellent response to budesonida.
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Victoria Busto Bea, Laura Crespo Pérez, Noemí García Miralles, Luis Ruiz del Árbol Olmos y Ana Cano Ruiz. Collagenous sprue: Don’t forget connective tissue in chronic diarrhea evaluation. 171-174


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