Year 2015 / Volume 107 / Number 4
Notas
Is the sinusoidal obstructive syndrome post-liver transplantation a pathologic entity with a multifactorial etiology?

235-239

Luis Miguel Marín-Gómez, José María Álamo-Martínez, Gonzalo Suárez-Artacho, José Ramírez-Santos, Carmen Bernal-Bellido, Lydia Barrera-Pulido, Juan Serrano-Díaz-Canedo, Francisco Javier Padillo-Ruiz and Miguel Ángel Gómez-Bravo

Abstract
The sinusoidal obstructive syndrome is a complication typically associated with hematopoietic stem cell transplantation. This syndrome, more commonly known as veno-occlusive disease, has also been described after liver transplantation. It can have a life-threatening course. Herein, we describe the hepatic graft loss secondary to the development of a sinusoidal obstructive syndrome after a severe acute cellular rejection and toxic levels of once daily modified released tacrolimus (TAC). We discuss the
role of the endotheliitis of acute rejection and toxic metabolites of some immunosuppressants such as azathioprine and TAC. Based on the current scientific evidence, we contemplate the possibility that the etiology of sinusoidal obstruction syndrome post-liver transplantation is multifactorial.
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Luis Miguel Marín-Gómez, José María Álamo-Martínez, Gonzalo Suárez-Artacho, José Ramírez-Santos, Carmen Bernal-Bellido, Lydia Barrera-Pulido, Juan Serrano-Díaz-Canedo, Francisco Javier Padillo-Ruiz and Miguel Ángel Gómez-Bravo. Is the sinusoidal obstructive syndrome post-liver transplantation a pathologic entity with a multifactorial etiology?. 235-239


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