Year 2015 / Volume 107 / Number 6
Review
Enteric neuropathy associated to diabetes mellitus

366-373

José Antonio Uranga-Ocio, Sonia Bastús-Díez, Drissa Delkáder-Palacios, Noemí García-Cristóbal, Miguel Ángel Leal-García and Raquel Abalo-Delgado

Abstract
Diabetes mellitus (DM) is a group of diseases highly prevalent nowadays. Its different types produce very similar symptoms with acute and chronic complications. Amongst these, gastrointestinal (GI) dysmotility, associated with the development of neuropathy in the enteric nervous system (ENS) is recognized. The objective is to review the current knowledge on GI dysmotility and enteric neuropathy associated to diabetes mellitus. The different functional and structural alterations within the digestive tract in diabetic patients and animal models are described. Finally, the therapeutic and preventive strategies tested so far in the context of enteric diabetic neuropathy are briefly summarized.
In conclusion, amongst the alterations described in DM, the loss of inhibitory intrinsic innervation of the gut is most remarkable. Different therapeutic and/or preventive strategies, including the use of insulin, nerve growth factor or antioxidants, as well as myenteric neuron transplantation, are proposed.
New comment
Comments
No comments for this article
Related articles
Citation tools
José Antonio Uranga-Ocio, Sonia Bastús-Díez, Drissa Delkáder-Palacios, Noemí García-Cristóbal, Miguel Ángel Leal-García and Raquel Abalo-Delgado. Enteric neuropathy associated to diabetes mellitus. 366-373


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 74 visits.
This article has been downloaded 53 times.
Share
This article has been rated by 1 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2025 y Creative Commons. The Spanish Journal of Gastroenterology