Year 2011 / Volume 103 / Number 8
Original
Trolox reduces the effect of ethanol on acetylcholine-induced contractions and oxidative stress in the isolated rabbit duodenum

pp. 396-401

Diego S. Fagundes, Sergio Gonzalo, Laura Grasa, Marta Castro, M.ª Pilar Arruebo, Miguel Ángel Plaza y M.ª Divina Murillo

Abstract
Trolox is a hydrophilic analogue of vitamin E and a free radical scavenger. Ethanol diminishes the amplitude of spontaneous contractions
and acetylcholine (ACh)-induced contractions in rabbit duodenum.
The aim of this work was to study the effect of Trolox on the alterations induced by ethanol on contractility and lipid peroxidation in the duodenum. The duodenal contractility studies in vitro were carried out in an organ bath and the levels of malondialdehyde
and 4-hydroxyalkenals (MDA+4-HAD) were measured by spectrophotometry.
Trolox increased the reduction induced by ethanol on the amplitude of spontaneous contractions in longitudinal muscle but not in circular muscle. Trolox 4 mM decreased the effects of
ethanol on ACh-induced contractions and on MDA+4-HDA concentrations.

We conclude that Trolox might prevent oxidative stress induced by ethanol in the duodenum.
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Diego S. Fagundes, Sergio Gonzalo, Laura Grasa, Marta Castro, M.ª Pilar Arruebo, Miguel Ángel Plaza y M.ª Divina Murillo. Trolox reduces the effect of ethanol on acetylcholine-induced contractions and oxidative stress in the isolated rabbit duodenum. 396-401


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