Year 2016 / Volume 108 / Number 12
Original
Spasmolytic effect of Jasonia glutinosa on rodent intestine

785-789

DOI: 10.17235/reed.2016.4327/2016

Marta Castro, Mariano Ramón Giménez, Francisco Les, Lorena Trejo, Miguel Ángel Plaza, Víctor López, María Divina Murillo, Marta Sofia Valero,

Abstract
Introduction: Jasonia glutinosa is an endemic plant species of the Iberian Peninsula and Southern France traditionally used in infusions as a spasmolytic; this plant is also known as “té de roca” (rock tea) but there is no scientific evidence about the effects of this plant. Aim: To evaluate the spasmolytic effect of rock tea. Methods: We have studied the in vitro effect of a rock tea extract on rat duodenum spontaneous contractions and the in vivo effect on mice gastrointestinal transit. Results: Rock tea extract reduced the spontaneous contractions of rat duodenal smooth muscle, inhibited KCl-induced contractions and blocked the contractions invoked by both extracellular Ca2+ and the agonist of L-type calcium channels Bay K8644. This inhibitory effect was similar to the one observed after the addition of the antagonist of L-type calcium channels verapamil. Rock tea did not modify gastrointestinal transit in healthy mice. However, after the treatment with dextran sulfate sodium, an inducer of colitis, rock tea extract reverted the increase in the gastrointestinal transit associated with this treatment. Conclusion: Rock tea extract relaxed duodenal smooth muscle via L-type calcium channels and normalized gastrointestinal transit in a model of colitis. These results may validate the traditional use of Jasonia glutinosa in patients with gastrointestinal alterations. Thus, rock tea may be used as a spasmolytic agent to treat gastrointestinal disorders.
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Castro M, Ramón Giménez M, Les F, Trejo L, Plaza M, López V, et all. Spasmolytic effect of Jasonia glutinosa on rodent intestine. 4327/2016


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Publication history

Received: 16/03/2016

Accepted: 01/09/2016

Online First: 02/11/2016

Published: 30/11/2016

Article revision time: 164 days

Article Online First time: 231 days

Article editing time: 259 days


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