Year 2015 / Volume 107 / Number 7
Original
Different mechanisms of actions of genistein and quercetin on spontaneous contractions of rabbit duodenum

413-416

Diego Santos-Fagundes, Laura Grasa, Sergio Gonzalo, Marta Sofía Valero, Marta Castro, María Pilar Arruebo, Miguel Ángel Plaza and María Divina Murillo

Abstract
Flavonoids are known to relax precontracted intestinal smooth muscle and delay intestinal transit or intestinal peristalsis. The aim of this study was to determine the effects of genistein and quercetin on spontaneous contractions of rabbit duodenum in vitro in an organ bath. Genistein and quercetin (0.1-10 µM) reduced the amplitude of spontaneous contractions in the longitudinal and circular smooth muscle of rabbit duodenum, but they did not modify the frequency. Bay K8644 (L-type Ca2+ channel activator), apamin, charybdotoxin, and tetraetylammonium (K+ channel blockers) reverted the inhibition of amplitude of spontaneous contractions induced by genistein in longitudinal and circular smooth muscle.
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Diego Santos-Fagundes, Laura Grasa, Sergio Gonzalo, Marta Sofía Valero, Marta Castro, María Pilar Arruebo, Miguel Ángel Plaza and María Divina Murillo. Different mechanisms of actions of genistein and quercetin on spontaneous contractions of rabbit duodenum. 413-416


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