Year 2011 / Volume 103 / Number 4
Notas
Diagnosis of Whipple’s disease using molecular biology techniques

pp. 213-217

Ángel Cosme, Evelia Ojeda, Ana I. Muñagorri, Eduardo Gaminde, Luis Bujanda, Mikel Larzabal e Inés Gil

Abstract
The diagnosis of Whipple’s disease (WD) is based on the existence of clinical signs and symptoms compatible with the disease and in the presence of PAS-positive diastase-resistant granules in
the macrophages of the small intestine. If there is suspicion of the disease but no histological findings or only isolated extraintestinal manifestations, species-specific PCR using different sequences of
the T. whippleii genome from different tissue types and biological fluids is recommended.
This study reports two cases: the first patient had diarrhea and the disease was suspected after an endoscopic examination of the ileum, while the second patient had multi-systemic manifestations,
particularly abdominal, thoracic, and peripheral lymphadenopathies.
In both cases, the diagnosis was confirmed using molecular biology techniques to samples from the small intestine or from a retroperineal lymph node, respectively.
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Ángel Cosme, Evelia Ojeda, Ana I. Muñagorri, Eduardo Gaminde, Luis Bujanda, Mikel Larzabal e Inés Gil . Diagnosis of Whipple’s disease using molecular biology techniques . 213-217


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