Year 2026 / Volume 118 / Number 1
Letter
Can flow cytometry be a key in the difficult diagnosis of coeliac disease? A case report

62-63

DOI: 10.17235/reed.2024.10833/2024

Andrés Castañeda, Marta Álvarez García, Cristina Serrano del Castillo, Raquel Téllez Pérez, Ana Pilar Lanzarote Vargas, María José Romero Valle, Lonore Hurtado de Mendoza, Sergio Farrais Villalba,

Abstract
We present the clinical case of a 39-year-old woman with a medical history of juvenile idiopathic arthritis and uveitis, evaluated for abdominal pain and distension, difficulty gaining weight, and diarrhea. Blood tests were requested, including antibodies which were negative and common genetic markers, showing positivity for HLA DQ 7.5. A gastroscopy with duodenal biopsies revealed findings consistent with stage 3b of the modified Marsh classification. Due to diagnostic uncertainty, an IEL study was performed, showing a characteristic CD pattern, leading to the initiation of a strict gluten-free diet (GFD). During follow-up, the patient showed partial improvement, with persistent digestive symptoms. A repeat endoscopic study revealed persistent atrophy, but refractory disease type 2 was ruled out. During a flare of rheumatologic disease, Tocilizumab was initiated by Rheumatology, resulting in improvement of duodenal atrophy.
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Castañeda A, Álvarez García M, Serrano del Castillo C, Téllez Pérez R, Lanzarote Vargas A, Romero Valle M, et all. Can flow cytometry be a key in the difficult diagnosis of coeliac disease? A case report. 10833/2024


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Publication history

Received: 01/10/2024

Accepted: 27/10/2024

Online First: 12/11/2024

Published: 14/01/2026

Article Online First time: 42 days

Article editing time: 470 days


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