Year 2015 / Volume 107 / Number 8
Letter to the Editor
BAX as a suseptibility factor in hereditary non polyposis colorectal cancer

520-521

Antonio Ríos, José Manuel Rodríguez, Pablo Carbonel and Pascual Parrilla

Abstract
Dear Editor,
BAX belongs to the Bcl-2 protein family and plays a vital role in the regulation of mitochondrial apoptotic pathway regulation in epithelial cells (1,2). It is frequently altered in tumors with a micro satellite instability phenotype (MSI) (3). Tumors with MSI are characterized by the low detection rate of mutations in apoptosis p53 gene promoters compared to those with MSS (micro satellite stability), which allows us to speculate about whether tumors with MSI could be related to BAX, instead of p53 (the gene involved in the change from adenoma to carcino- ma).
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Antonio Ríos, José Manuel Rodríguez, Pablo Carbonel and Pascual Parrilla. BAX as a suseptibility factor in hereditary non polyposis colorectal cancer. 520-521


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