Year 2022 / Volume 114 / Number 1
Letter
Capecitabine-induced hyperammonemic encephalopathy

56

DOI: 10.17235/reed.2021.8129/2021

Carolina Cerrella Cano, Eduardo Junquera Alonso, Marina Terroba Alonso, Francisco Xavier Cano Calderero, Lucía Seoane Blanco, Edisa M. Armesto González,

Abstract
We report the case of a 79-year-old male who had undergone surgery for a mucus-secreting, stage-III pancreatic adenocarcinoma 2 years previously, who was recently started on capecitabine monotherapy for radiographic local progression. He developed disorientation, asterixis, nausea and elevated serum ammonia (221 μmol/L) 48-72 hours after treatment onset with preserved liver function. After ruling out potential causes of encephalopathy and tumor progression by abdominal and brain CT scans, his symptoms were related by exclusion to the recently initiated treatment with capecitabine. Capecitabine discontinuation, onset of standard anti-encephalopathy measures, and intravenous hydration led to a rapid, complete resolution of symptoms with serum ammonia normalization.
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References
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Citation tools
Cerrella Cano C, Junquera Alonso E, Terroba Alonso M, Cano Calderero F, Seoane Blanco L, Armesto González E, et all. Capecitabine-induced hyperammonemic encephalopathy. 8129/2021


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Publication history

Received: 01/06/2021

Accepted: 03/06/2021

Online First: 22/06/2021

Published: 10/01/2022

Article Online First time: 21 days

Article editing time: 223 days


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