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Year 2025 / Volume 117 / Number 5
Original

LncRNA OIP5-AS1 mediated miR-28-5p provides promising support for the diagnosis and prognosis of cholangiocarcinoma

256-264

DOI: 10.17235/reed.2024.10632/2024

Yanqing Gong, Huimin Wang, Xiaoming Wang, Deli Kuang, Chunmiao Yuan, Jianhua Ju,

Abstract

Background: long non-coding RNAs (lncRNAs) are a major research focus in a variety of diseases, and lncRNA OIP5-AS1 (OIP5-AS1) was shown to mediate the progression of various tumors. This article discusses how OIP5-AS1 could potentially be used to diagnose and prognosticate cholangiocarcinoma (CHOL). Methods: the ENROCI project evaluated OIP5-AS1 expression in CHOL samples, which was confirmed by RT-qPCR. A bioinformatics database predicted the target gene of OIP5-AS1 in CHOL, which was then confirmed by luciferase activity assays. The CCK-8 and Transwell methods were employed to detect the changes in CHOL cell growth and migration levels after OIP5-AS1 knockdown. ROC and Kaplan-Meier curves were used to examine the diagnostic and prognostic functions of OIP5-AS1. Results: in CHOL tissues and cells, OIP5-AS1 was enhanced compared to the controls. Reducing OIP5-AS1 hampered the regulatory capacity of CHOL cells, which was restored by the miR-28-5p inhibitor. Notably, OIP5-AS1 was observed to sponge and downregulate miR-28-5p, exhibiting high sensitivity and specificity (84.4 % and 81.3 %) in CHOL. G3BP1 was a direct target of miR-28-5p. Decreased OIP5-AS1 level was beneficial for survival (HR = 2.391, p = 0.024). Conclusion: OIP5-AS1 targets and negatively mediates miR-28-5p/G3BP1 axis to promote the activity of CHOL cells, which may be a potential marker for diagnosis and prognosis of CHOL patients.

Lay Summary

Long non-coding RNAs are a major research focus in a variety of diseases, and lncRNA OIP5-AS1 (OIP5-AS1) was shown to mediate the progression of various tumors. This paper discusses how OIP5-AS1 could potentially be used to diagnose and prognosticate cholangiocarcinoma. In our study, OIP5-AS1 expression was upregulated in cholangiocarcinoma tissues and cells, and was related to shorter survival time. OIP5-AS1 targets and negatively mediates miR-28-5p/G3BP1 axis to promote the activity of cholangiocarcinoma cells, which may be a potential marker for diagnosis and prognosis of cholangiocarcinoma patients.

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DOI: 10.17235/reed.2019.6183/2019

Original

Prognostic influence of CDX2 expression in gastric carcinoma after surgery with a curative intent

DOI: 10.17235/reed.2019.5976/2018

Review

Meta-analysis of the diagnostic value of contrast-enhanced ultrasound for the detection of vascular complications after liver transplantation

DOI: 10.17235/reed.2018.5818/2018

Original

The efficiency of several one-step testing strategies for the diagnosis of hepatitis C

DOI: 10.17235/reed.2018.5810/2018

Original

First hospital contact via the Emergency Department is an independent predictor of overall survival and disease-free survival in patients with colorectal cancer

DOI: 10.17235/reed.2019.5777/2018

Original

Klatskin tumors and “Klatskin-mimicking lesions”: our 22-year experience.

DOI: 10.17235/reed.2018.5749/2018

Letter

An unusual case report of inflammatory fibrous polyps in the upper gastrointestinal tract

DOI: 10.17235/reed.2018.5734/2018

Original

Analysis of rebleeding in cases of an upper gastrointestinal bleed in a single center series

DOI: 10.17235/reed.2018.5702/2018

Original

Primary biliary cholangitis in Spain. Results of a Delphi study of epidemiology, diagnosis, follow-up and treatment

DOI: 10.17235/reed.2018.5665/2018

Review

Meckel’s diverticulum: clinical features, diagnosis and management

DOI: 10.17235/reed.2018.5628/2018

Case Report

Endoscopic closure of tracheoesophageal fistula for tuberculosis with an over-the-scope-clip

DOI: 10.17235/reed.2018.5563/2018

Editorial

The right colon challenge

DOI: 10.17235/reed.2018.5544/2018

Original

Long noncoding RNAs as diagnostic biomarkers for the early detection of digestive tract cancers: a systematic review and meta-analysis

DOI: 10.17235/reed.2020.5450/2018

Original

Endoscopic ultrasound cytologic brushing vs endoscopic ultrasound - fine needle aspiration for cytological diagnosis of cystic pancreatic lesions. A multicenter, randomized open-label trial

DOI: 10.17235/reed.2018.5449/2017

Original

Analysis of the diagnostic yield of endoscopic ultrasonography-guided fine-needle aspiration in patients with a suspected pancreatic malignancy

DOI: 10.17235/reed.2018.5455/2017

Special Article

Recommendations to report and interpret HLA genetic findings in coeliac disease

DOI: 10.17235/reed.2018.5269/2017

Original

Gastrointestinal stromal tumors: 16 years’ experience within a university hospital

DOI: 10.17235/reed.2018.5199/2017

Review

Intestinal tuberculosis and Crohn’s disease: the importance and difficulty of a differential diagnosis

DOI: 10.17235/reed.2018.5184/2017

Letter to the Editor

Neuroendocrine tumors of the pancreas: keys issues in dealing with heterogeneity

DOI: 10.17235/reed.2017.4997/2017

Letter to the Editor

Pancreatic neuroendocrine tumors. Prognostic factors

DOI: 10.17235/reed.2017.5109/2017

Letter to the Editor

Sternal cutaneous metastasis of hilar cholangiocarcinoma

DOI: 10.17235/reed.2017.4979/2017

Original

Clinical manifestations and endoscopic presentations of gastric lymphoma: a multicenter seven year retrospective survey

DOI: 10.17235/reed.2017.4882/2017

Case Report

Intraductal papillary neoplasia of the bile duct with malignancy: a differentiated entity of cholangiocarcinoma with a better prognosis. A review of three new cases

DOI: 10.17235/reed.2017.4835/2016

Editorial

Pancreas neuroendocrine tumors - not so rare or benign

DOI: 10.17235/reed.2016.4672/2016

Original

Matrix metalloproteases expression in different histological types of colorectal polyps

DOI: 10.17235/reed.2017.4551/2016

Original

The use of a segmental endoscopic score may improve the prediction of clinical outcomes in acute severe ulcerative colitis

DOI: 10.17235/reed.2016.4470/2016

Letter to the Editor

About human taeniasis and Taenia saginata diagnosis by endoscopy

DOI: 10.17235/reed.2016.4297/2016

Case Report

Intrahepatic clear cell cholangiocarcinoma - An uncommon histologic subtype: case report and literature review

DOI: 10.17235/reed.2017.4239/2016

Digestive Diseases Image

Endoscopic removal of multiple sharp gastro-duodenal foreign bodies

Letter to the Editor

Lupus as a paraneoplastic manifestation of cholangiocarcinoma

DOI: 10.17235/reed.2016.4064/2015

Case Report

Primary non-functioning neuroendocrine tumor of the extrahepatic bile duct

DOI: 10.17235/reed.2016.4071/2015

Letter to the Editor

TIPS treatment in a patient with severe lower gastrointestinal bleeding with a misdiagnosis of cirrhotic portal hypertension

DOI: 10.17235/reed.2015.3794/2015

Case Report

Liver failure posthepatectomy and biliary fistula: multidisciplinar treatment

DOI: 10.17235/reed.2015.3747/2015

Original

Impact of the age of diagnosis on the natural history of ulcerative colitis

DOI: 10.17235/reed.2015.3736/2015

Case Report

Endoscopy as a diagnostic and therapeutic alternative technique of taeniasis

DOI: 10.17235/reed.2015.3585/2014

Citation tools

Gong Y, Wang H, Wang X, Kuang D, Yuan C, Ju J, et all. LncRNA OIP5-AS1 mediated miR-28-5p provides promising support for the diagnosis and prognosis of cholangiocarcinoma. 10632/2024

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Publication history

Received: 04/07/2024

Accepted: 12/12/2024

Online First: 09/01/2025

Published: 08/05/2025

Article Online First time: 189 days

Article editing time: 308 days

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