References
[1] S.M. Mugie, M.A. Benninga, C. Di Lorenzo, Epidemiology of constipation in children and adults: a systematic review, Best practice & research. Clinical gastroenterology. 2011;25(1): 3-18.
[2] C.J. Black, A.C. Ford, Chronic idiopathic constipation in adults: epidemiology, pathophysiology, diagnosis and clinical management, The Medical journal of Australia. 2018;209(2): 86-91.
[3] C. Guo, Q. Peng, Q. Ao, Z. Zheng, X. Yu, Association between body roundness index and constipation using data from NHANES 2005-2010, Scientific reports. 2025;15(1): 13271.
[4] T. Sommers, C. Corban, N. Sengupta, M. Jones, V. Cheng, A. Bollom, et al., Emergency department burden of constipation in the United States from 2006 to 2011, The American journal of gastroenterology. 2015;110(4): 572-9.
[5] N. Alsheridah, S. Akhtar, Diet, obesity and colorectal carcinoma risk: results from a national cancer registry-based middle-eastern study, BMC cancer. 2018;18(1): 1227.
[6] A. Psichas, M.L. Sleeth, K.G. Murphy, L. Brooks, G.A. Bewick, A.C. Hanyaloglu, et al., The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents, International journal of obesity (2005). 2015;39(3): 424-9.
[7] M. Camilleri, Leaky gut: mechanisms, measurement and clinical implications in humans, Gut. 2019;68(8): 1516-1526.
[8] N.J. Talley, S. Howell, R. Poulton, Obesity and chronic gastrointestinal tract symptoms in young adults: a birth cohort study, The American journal of gastroenterology. 2004;99(9): 1807-14.
[9] E.A. Silveira, A. Santos, J.N. Ribeiro, M. Noll, A.P. Dos Santos Rodrigues, C. de Oliveira, Prevalence of constipation in adults with obesity class II and III and associated factors, BMC gastroenterology. 2021;21(1): 217.
[10] I.J. Koppen, C.A. Velasco-Benítez, M.A. Benninga, C. Di Lorenzo, M. Saps, Is There an Association between Functional Constipation and Excessive Bodyweight in Children?, The Journal of pediatrics. 2016;171: 178-82.e1.
[11] O.O. Woolcott, R.N. Bergman, Relative fat mass (RFM) as a new estimator of whole-body fat percentage ─ A cross-sectional study in American adult individuals, Scientific reports. 2018;8(1): 10980.
[12] B. Xiao, C. Cao, Y. Han, H. Hu, Y. He, Non-linear relationship between relative fat mass and diabetes risk in Japanese adults: a retrospective cohort study, Scientific reports. 2024;14(1): 23496.
[13] O.O. Woolcott, E. Samarasundera, A.K. Heath, Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality, Scientific reports. 2024;14(1): 30823.
[14] H. Liu, M. Jin, H. Hao, Y. Yuan, H. Jia, Y. Zhou, Association between relative fat mass and kidney stones in American adults, Scientific reports. 2024;14(1): 27045.
[15] X. Zhu, Y. Yue, L. Li, L. Zhu, Y. Cai, Y. Shu, The relationship between depression and relative fat mass (RFM): A population-based study, Journal of affective disorders. 2024;356: 323-328.
[16] N. Xiang, L. Xu, H. Qian, D. Zhang, Multiple obesity indices suggest a close relationship between obesity and constipation: evidence from NHANES, BMC public health. 2024;24(1): 1273.
[17] X. Hou, H. Wang, Z. Yang, Y. Jia, Y. Lv, X. Dong, Association between physical activity, trouble sleeping, and obesity among older Americans: a cross-sectional study based on NHANES data from 2007 to 2018, BMC geriatrics. 2025;25(1): 165.
[18] Y. Yang, S. Rao, Y. Zhuo, Y. Fang, J. Wan, D. You, Association between constipation and the urine albumin-to-creatinine ratio in adults: the NHANES 2009-2010, Frontiers in nutrition. 2025;12: 1477148.
[19] Y. Hong, H. Shen, X. Chen, G. Li, Gender differences in the association between dietary protein intake and constipation: findings from NHANES, Frontiers in nutrition. 2024;11: 1393596.
[20] X. Yang, M. Wang, L. Ren, K. Shon, G. Cui, Y. Cheng, et al., Association between visceral adiposity index and bowel habits and inflammatory bowel disease: a cross-sectional study, Scientific reports. 2024;14(1): 23923.
[21] E.D. Sonnenburg, J.L. Sonnenburg, Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates, Cell metabolism. 2014;20(5): 779-786.
[22] A.D. Markland, O. Palsson, P.S. Goode, K.L. Burgio, J. Busby-Whitehead, W.E. Whitehead, Association of low dietary intake of fiber and liquids with constipation: evidence from the National Health and Nutrition Examination Survey, The American journal of gastroenterology. 2013;108(5): 796-803.
[23] H.Y. Jeong, D.H. Park, J.K. Lee, Levator plate descent angle in pelvic floor disorders, Techniques in coloproctology. 2021;25(9): 1011-1018.
[24] J.A. Batsis, D.T. Villareal, Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies, Nature reviews. Endocrinology. 2018;14(9): 513-537.
[25] T. Shima, R. Amamoto, C. Kaga, Y. Kado, T. Sasai, O. Watanabe, et al., Association of life habits and fermented milk intake with stool frequency, defecatory symptoms and intestinal microbiota in healthy Japanese adults, Beneficial microbes. 2019;10(8): 841-854.
[26] G. Mancia, G. Grassi, The autonomic nervous system and hypertension, Circulation research. 2014;114(11): 1804-14.
[27] J.J. Zhou, H.J. Ma, J.Y. Shao, H.L. Pan, D.P. Li, Impaired Hypothalamic Regulation of Sympathetic Outflow in Primary Hypertension, Neuroscience bulletin. 2019;35(1): 124-132.
[28] K. Kaewsaro, S. Nualplub, S. Bumrungsri, P. Khuituan, Furosemide suppresses ileal and colonic contractility via interactions with GABA-A receptor in mice, Clinical and experimental pharmacology & physiology. 2017;44(11): 1155-1165.
[29] N.R. Hurst, D.M. Kendig, K.S. Murthy, J.R. Grider, The short chain fatty acids, butyrate and propionate, have differential effects on the motility of the guinea pig colon, Neurogastroenterology and motility. 2014;26(11): 1586-96.
[30] M. Camilleri, Sex as a biological variable in irritable bowel syndrome, Neurogastroenterology and motility. 2020;32(7): e13802.
[31] L.A. Houghton, R. Lea, N. Jackson, P.J. Whorwell, The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers, Gut. 2002;50(4): 471-4.