Year 2026 / Volume 118 / Number 2
Letter
Acute acalculous cholecystitis secondary to hepatitis A infection

115-116

DOI: 10.17235/reed.2024.10941/2024

Irene González Díaz, Marta Abadía Barnó, Carmen Amor Costa, Clara Amiama Roig,

Abstract
Acute acalculous cholecystitis (AAC) of infectious origin represents a small percentage of all cases of cholecystitis. According to the literature, the most common pathogens include Salmonella typhii and Epstein-Barr virus (EBV). However, AAC has also been described as a rare complication in the context of other viral hepatitis infections, with only a few reported cases attributed to hepatitis A virus (HAV) infection. We present the case of a patient with AAC secondary to HAV infection, which resolved favorably with conservative management. We report the case of a 29-year-old male presenting with jaundice, abdominal pain, and fever lasting three days. Laboratory results revealed elevated transaminase levels with a cholestatic pattern and hyperbilirubinemia, predominantly direct bilirubin. Abdominal ultrasound showed a gallbladder with a thickened, heterogeneous, poorly defined, and disorganized wall, along with multiple enlarged perihilar lymph nodes and a positive Murphy's sign. Serological testing for hepatopathy revealed positive IgM antibodies for HAV, confirming the diagnosis of hepatitis A. Seven days later, follow-up testing demonstrated normalization of both laboratory parameters and ultrasound findings following resolution of the viral illness.
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References
1. Portincasa P, Moschetta A, Di Ciaula A, et al. Changes of gallbladder and gastric dynamics in patients with acute hepatitis A. Eur J Clin Invest. 2001;31:617-22.6.
2. Basar O, Kisacik B, Bozdogan E, Yolcu OF, Ertugrul I, KokluS. An unusual cause of acalculous cholecystitis duringpregnancy: hepatitis A virus. Dig Dis Sci. 2005;50:1532.
3. Markaki I, Konsoula A, Markaki L, Spernovasilis N, Papadakis M. Acute acalculous cholecystitis due to infectious causes. World J Clin Cases. 2021 Aug 16;9(23):6674-6685.
4. Mourani S, Dobbs SM, Genta RM, Tandon AK, Yoffe B. Hepatitis A virus-associated cholecystitis. Ann Intern Med. 1994;120:398-400.
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González Díaz I, Abadía Barnó M, Amor Costa C, Amiama Roig C. Acute acalculous cholecystitis secondary to hepatitis A infection . 10941/2024


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Publication history

Received: 12/11/2024

Accepted: 15/11/2024

Online First: 26/11/2024

Published: 09/02/2026

Article Online First time: 14 days

Article editing time: 454 days


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