Year 2025 / Volume 117 / Number 12
Letter
Trousseau syndrome preceding the diagnosis of colon cancer

770-771

DOI: 10.17235/reed.2024.10728/2024

Daniel Alvarenga Fernandes, Fernando Brandão Alcântara Santos, Fernanda Veloso Pereira, Carlos Eduardo Garcez Teixeira, Zoraida Sachetto, Ilka de Fátima Ferreira Santana Boin, José Barreto Campello Carvalheira, Fabiano Reis,

Abstract
Trousseau Syndrome (TS) is defined as the occurrence of thromboembolic events prior to or simultaneously with the diagnosis of visceral neoplasia. In cases of multiple thromboembolisms, considering the possibility of TS, a screening for neoplasms may be warranted. We present a case study of a 61-year-old female who presented a neurological deficit. Brain magnetic resonance imaging (MRI) showed multiple hyperintense bihemispheric foci in subcortical and cortical regions involving three different vascular territories in the FLAIR sequence, associated with restricted diffusion inferring cytotoxic edema and indicating that they were all recent ischemic lesions, raising the hypothesis of TS. The patient underwent neoplastic screening with a subsequent diagnosis of colon cancer. TS should be considered when the patient presents thromboembolic events without an established cause. The three-territories-sign (TTS) is an essential radiographic biomarker related to cancer-associated ischemic stroke (CAIS). We propose that our findings be considered for the inclusion of guidelines that determine the investigation of an occult tumor (particularly gastric, pancreatic, lung, and colorectal) in patients who present thrombotic events, especially TTS.
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Fernandes D, Santos F, Pereira F, Teixeira C, Sachetto Z, Boin I, et all. Trousseau syndrome preceding the diagnosis of colon cancer. 10728/2024


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Publication history

Received: 20/08/2024

Accepted: 10/09/2024

Online First: 19/09/2024

Published: 12/12/2025

Article Online First time: 30 days

Article editing time: 479 days


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