Year 2019 / Volume 111 / Number 6
Letter
Whipple’s disease: when diarrhea is absent

492-493

DOI: 10.17235/reed.2019.6015/2018

Sagrario María Santos Seoane, Rocío Martínez Gutiérrez, Victoria Ines Venta Menéndez,

Abstract
Whipple's disease is a rare bacterial, chronic and multisystemic disease, produced by the gram-positive bacillus Tropheryma whipplei. The clinical manifestations are varied and diagnosis is often delayed. The four cardinal symptoms are arthralgias, weight loss, diarrhea and abdominal pain. The classic symptoms could be preceded up to three quarters by different joint manifestations that evolve intermittently. The average time to diagnosis is 6 years. We present the case of a young patient with recurrent febrile episodes and associated joint disease, in whom the absence of digestive symptoms led to a diagnostic laparoscopy since this entity was not suspected before.
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28/11/2019 6:02:43
Amazing


References
1 Juanmartiñena Fernández JF, Oyón Lara D, Rázquin Lizarraga S et al. Whipple's disease under the vision of capsule endoscopy. Rev Esp Enferm Dig. 2016 Sep;108(9):606. Doi: 10.17235/reed.2016.4362/2016)
2 Günther U, Moos V, Offenmüller G, et al. Gastrointestinal diagnosis of classical Whipple disease: clinical, endoscopic, and histopathologic features in 191 patients. Medicine (Baltimore) 2015; 94:e714.
3 Lagier JC, Lepidi H, Raoult D, Fenollar F. Systemic Tropheryma whipplei: clinical presentation of 142 patients with infections diagnosed or confirmed in a reference center. Medicine (Baltimore) 2010; 89:337.
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Santos Seoane S, Martínez Gutiérrez R, Venta Menéndez V. Whipple’s disease: when diarrhea is absent. 6015/2018


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Publication history

Received: 30/10/2018

Accepted: 07/11/2018

Online First: 29/05/2019

Published: 07/06/2019

Article Online First time: 211 days

Article editing time: 220 days


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