Year 2017 / Volume 109 / Number 4
Letter to the Editor
Invasive pulmonary aspergillosis in an immunocompromised patient with severe ulcerative colitis

316-317

DOI: 10.17235/reed.2017.4564/2016

David Marti Aguado, María Pilar Ballester, Marta Maia Bosca Watts,

Abstract
Inflammatory bowel disease patients at risk of opportunistic infections are those treated with immunomodulators. Toruner and colleagues found that corticosteroid use was more commonly associated with fungal infections. We present a case of invasive pulmonary Aspergillosis due to corticosteroid therapy in the context of a severe Ulcerative Colitis flare. We want to highlight the relationship between Aspergillus fumigatus and horses; and the use of leucocitapheresis combined with mesalazine as an effective treatment option in this patients who can not take more immunosuppressive therapy.
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References
1. Toruner M, Loftus EV Jr, Harmsen WS, Zinsmeister AR, Orenstein R, Sandborn WJ, Colombel JF, Egan LJ. Risk factors for opportunistic infections in patients with inflamatory bowel disease. Gastroenterology 2008 Apr;134(4):929-36. doi: 10.1053.
2. Rahier JF, Magro F, Abreu C, Armuzzi A, Ben-Horin S, Chowers Y, Cottone M, de Ridder L, Doherty G, Ehehalt R, Esteve M, Katsanos K, Lees CW, Macmahon E, Moreels T, Reinisch W, Tilg H, Tremblay L, Veereman-Wauters G, Viget N, Yazdanpanah Y, Eliakim R, Colombel JF; European Crohn's and Colitis Organisation (ECCO). Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. J Crohns Colitis. 2014 Jun;8(6):443-68. doi: 10.1016.
3. Guida N, Mesplet M, Di Gennaro E, Digilio P, Moras EV. Aspergillus fumigatus in nasopharyngeal cavity of horses. Rev Iberoam Micol 2005 Sep;22(3):160-2.
4. Saniabadi AR, Tanaka T, Ohmori T, Sawada K, Yamamoto T, Hanai H. Treating inflammatory bowel disease by adsorptive leucocytapheresis: a desire to treat without drugs. World Journal Gastroenterology. 2014 Aug 7;20(29):9699-715. doi: 10.3748/wjg. v20.i29.9699.
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Marti Aguado D, Ballester M, Bosca Watts M. Invasive pulmonary aspergillosis in an immunocompromised patient with severe ulcerative colitis. 4564/2016


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Publication history

Received: 30/07/2016

Accepted: 30/08/2016

Online First: 23/02/2017

Published: 31/03/2017

Article revision time: 3 days

Article Online First time: 208 days

Article editing time: 244 days


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