Year 2025 / Volume 117 / Number 10
Letter
A key aspect of randomized controlled trials: allocation concealment

599-600

DOI: 10.17235/reed.2024.10906/2024

Joaquín González Aroca,

Abstract
Preoperative rehabilitation, or prehabilitation, plays a crucial role in improving outcomes for patients undergoing complex surgeries like pancreaticoduodenectomy. In the article “Prehabilitation in Patients Undergoing Pancreaticoduodenectomy: A Randomized Controlled Trial” by Ausania et al., valuable insights are provided into this emerging field. However, key methodological details, such as the randomization process and allocation concealment, were not fully described. Randomization and allocation concealment are essential in randomized controlled trials to prevent selection bias and ensure valid, unbiased results. Without proper allocation concealment, the trial's outcomes may be skewed, overestimating treatment effects. This paper underscores the importance of transparent reporting of these processes to maintain scientific rigor and enhance the reliability of study findings.
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References
1. Ausania F, Senra P, Meléndez R, Caballeiro R, Ouviña R, Casal-Núñez E. Prehabilitation in patients undergoing pancreaticoduodenectomy: a randomized controlled trial. Rev Esp Enferm Dig. 2019 Aug;111(8):603-608. doi: 10.17235/reed.2019.6182/2019.
2. Attia, A. (2005) Bias in RCTs: confounders, selection bias and allocation concealment. Middle East Fertility Society, 10 (3), 258–261
3. Altman DG, Schulz KF. Statistics notes: Concealing treatment allocation in randomised trials. BMJ. 2001 Aug 25;323(7310):446-7. doi: 10.1136/bmj.323.7310.446.
4. Herbison, P., Hay-Smith, J. & Gillespie, W. J. (2011) Different methods of allocation to groups in randomized trials are associated with different levels of bias. A meta-epidemiological study. Journal of Clinical Epidemiology, 64 (10), 1070–1075.
5. Dettori J. The random allocation process: two things you need to know. Evid Based Spine Care J. 2010 Dec;1(3):7-9. doi: 10.1055/s-0030-1267062.
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González Aroca J. A key aspect of randomized controlled trials: allocation concealment . 10906/2024


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Publication history

Received: 28/10/2024

Accepted: 01/11/2024

Online First: 19/11/2024

Published: 10/10/2025

Article Online First time: 22 days

Article editing time: 347 days


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