Year 2020 / Volume 112 / Number 7
Original
Quality of life study in asymptomatic patients with hepatitis C

520-524

DOI: 10.17235/reed.2019.6339/2019

Raúl Honrubia López, Antonio Madejón Seiz, Miriam Romero Portales, Araceli García Sánchez, Pilar Castillo Grau, José Carlos Erdozain Sosa, Antonio Olveira Martín, Ana Robles, Javier García-Samaniego Rey,

Abstract
Objective and methods: an observational, longitudinal, prospective study was performed to assess changes in perceived quality of life in asymptomatic patients with hepatitis C under treatment with direct-acting antivirals. Questionnaires SF-36 and EQ-5D-5L were administered to 86 treated patients and 12 controls. Results: there were improvements in several parameters such as physical functioning, bodily pain, general health, vitality and social functioning, particularly when the perceptions were compared before treatment and after treatment completion and following recovery. Conclusion: these data support the hypothesis that the hepatitis C virus may worsen quality of life in asymptomatic patients.
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References
1.EuroQol. EQ-5D-5L user guide: basic information on how to use the EQ-5D-5L instrument. 2014; (Available from: https://www.euroqol.org/wp-content/uploads/2016/09/EQ-5D-5L_UserGuide_2015.pdf
2. Hays RD, Morales LS. The RAND-36 measure of health-related quality of life. Ann Med 2001;33:350-357
3. Strauss E, Porto-Ferreira FA, de Almeida-Neto C, et al. Altered quality of life in the early stages of chronic hepatitis C is due to the virus itself- Clin Res HepatolGastroenterol. 2014 Feb; 38(1): 40-45
4. Younossi ZM, Stepanova M, Marcellin P, et al. Treatment with ledipasvir and sofosbuvir improves patient-reported outcomes: Results from the ION-1, -2, amd -3 clinical trials.Hepatology 2015 Jun,61(6): 1798-808
5. Younossi ZM, Stepanova M, Henry L. Performace and Validation of Chronic Liver Disease Questionnaire-Hepatitis C Version (CLDQ-HCV) in Clinical Trials of Patients with Chronic Hepatitis C. Value Health 2016 Jul-Aug; 19(5):544-551
6. Janssen MF, Pickard AS, Golicki D, et al. Measurement properties of the EQ-5D-5L compared to the EQ-5D-3L across eight patient groups: a multi-country study. Qual Life Res. 2013; 22: 1717-1727
7. Agborsangaya C, BLahtinen M, Cooke T, et al. Comparing the EQ-5D 3L and 5L: measurement properties and association with chronic conditions and multimorbidityin the general population. Health Qual Life Outcomes. 2014;12:74
8. Negro F. Adverse effects of drugs in the treatment of viral hepatitis. Best Prat Res ClinGastroenterol. 2010; 24:183-92
9. Geddaway A, Ibrahim YF, Elbahie NM, et al. Direct acting anti-hepatitis C virus drugs: clinical pharmacology and future directions.JTranslInt Med. 2017 ; 5:8-17
10 .Huang R, Rao H, Shang J. et al. A cross-sectional assessment of health-related quality of life in Chinese patients with chronic hepatitis c virus infection with EQ-5D. Health and Quality of Life Outcome (2018) 16:124
11. Goñi Esarte S, Juanbeltz R, Martínez-Baz I, et al. Long-term changes on health-related quality of life in patients with chronic hepatitis C after viral clearance with direct-acting antiviral agents. Rev Esp Enferm Dig 2019. doi: 10.17235/reed.2019.6063/2018.
12. Sigueira FM, Ferreira VL, Borba HHL, et al. Quality of life of Brazilian chronic hepatitis C patients treated with interferon-free therapies. Rev Inst Med Trop Sao Paulo 2018 Nov 14;60:e72
13. Gutteling JJ, De Man RA, Van der Plas SM, et al. Determinants of quality of life in chronic liver patients. Aliment PharmacolTher. 2006;23:1629-1635
14. Lowry D, Coughlan B, McCarthy O, et al. Investigating health-related quality of life, mood and neuropsychological test performance in a homogeneous cohort of Irish female hepatitis C patients. J Viral Hepat. 2010 May;17(5):352-9
15. Weissenborn K, Ennen JC, Bokemeyer M, et al. Monoaminergic neurotransmission is altered in hepatitis C virus infected patients with chronic fatigue and cognitive impairment. Gut. 2006;55:1624-1630
16. Helbling B, Overbeck K, Gonvers JJ, et al. Host-rather than virus-related factors reduce health-related quality of life in hepatitis C virus infection. Gut. 2008;57:1597-1603
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Honrubia López R, Madejón Seiz A, Romero Portales M, García Sánchez A, Castillo Grau P, Erdozain Sosa J, et all. Quality of life study in asymptomatic patients with hepatitis C. 6339/2019


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Publication history

Received: 15/04/2019

Accepted: 26/05/2019

Online First: 16/10/2019

Published: 08/07/2020

Article revision time: 33 days

Article Online First time: 184 days

Article editing time: 450 days


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