Year 2018 / Volume 110 / Number 7
Special Article
Recommendations to report and interpret HLA genetic findings in coeliac disease

458-461

DOI: 10.17235/reed.2018.5269/2017

Concepción Núñez, José Antonio Garrote, Eduardo Arranz, José Ramón Bilbao, Fernando Fernández Bañares, Juana Jiménez, Teresa Perucho, Eva Ruiz Casares, Félix Sánchez-Valverde, Juan I. Serrano,

Abstract
Coeliac disease (CD) is a chronic autoimmune enteropathy triggered by gluten and related prolamines in genetically predisposed individuals. Although CD is a polygenic disease, there is a strong association with genes of the human leukocyte antigen (HLA) region. Most patients present the HLA-DQ2 heterodimer, specifically the DQ2.5 isoform, which is present in around 90-96% of patients of European ancestry.
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Citation tools
Núñez C, Garrote J, Arranz E, Bilbao J, Fernández Bañares F, Jiménez J, et all. Recommendations to report and interpret HLA genetic findings in coeliac disease. 5269/2017


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Publication history

Received: 20/09/2017

Accepted: 01/02/2018

Online First: 03/05/2018

Published: 02/07/2018

Article revision time: 120 days

Article Online First time: 225 days

Article editing time: 285 days


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