Year 2025 / Volume 117 / Number 8
Letter
A rare early gastric mixed neuroendocrine-non-neuroendocrine neoplasm misdiagnosed as early gastric cancer

479-481

DOI: 10.17235/reed.2024.10933/2024

Pengwei Liu, Yan Zhang,

Abstract
Recently, mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) have attracted more attention. However, early gastric MiNEN is uncommon, and there are rare reports on the characteristics of it. As its clinical and endoscopic features are resemble to early gastric cancer (EGC), it can be easily misdiagnosed. The purpose of this article is to elaborate the endoscopic and pathological characteristics of early gastric MiNEN, which is of great significance for distinguishing it from EGC. A 67-year-old male patient underwent EGD revealing a 0-IIc+IIa lesion on the lesser curvature of the lower stomach body. The biopsy pathology indicated the lesion was an EGC. Endoscopic submucosal dissection (ESD) was subsequently applied to remove the lesion. According to postoperative pathological, the lesion was diagnosed as early MiNEN (tubular adenocarcinoma 50%, neuroendocrine carcinoma 50%), pT1b (submucosa 600 μm), pUL (1), Ly (0), v (1), pHM0, pVM0. And after that, surgical resection were added. A follow-up CT scan and endoscopy performed six months later revealed no metastasis or recurrence. This case highlights that early gastric MiNEN could mimic ECG. We deemed that ME-NBI combined with pathological biopsy could contribute to the identification of early gastric MiNEN.
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References
1. Toor D, Loree JM, Gao ZH, Wang G, Zhou C: Mixed neuroendocrine-non-neuroendocrine neoplasms of the digestive system: A mini-review. World J Gastroenterol 2022, 28(19):2076-2087.
2. Costa JDE, Costa RS, Moreira HD, Ferreira A: Gastric mixed neuroendocrine/non neuroendocrine neoplasia: a rare entity. Rev Esp Enferm Dig 2023, 115(11):670-671.
3. Miyaguchi K, Kawasaki T, Tashima T, Ryozawa S: Mixed neuroendocrine-non-neuroendocrine neoplasm arising from long-segment Barrett's esophagus showing exceptionally aggressive clinical behavior. Cancer Rep (Hoboken) 2022, 5(9):e1644.
4. Tsvetkova V, Luchini C: Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms of the Pancreas. Surg Pathol Clin 2022, 15(3):555-563.
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Liu P, Zhang Y. A rare early gastric mixed neuroendocrine-non-neuroendocrine neoplasm misdiagnosed as early gastric cancer. 10933/2024


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Publication history

Received: 10/11/2024

Accepted: 14/11/2024

Online First: 26/11/2024

Published: 24/07/2025

Article Online First time: 16 days

Article editing time: 256 days


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